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44 Cards in this Set

  • Front
  • Back
Sterilization
destroys all viable microbes: viruses and endospores
Disinfection
destroy VEGETATIVE pathogens
inamnimate objects
Antiseptic:
disinfectant applied to exposed body surfaces
Sanitization
mechanically removing microbes: cleansing technique
Degermination
REDUCING number of microbes
Microbial death
permanent loss of reproductive capability- even under OPTIMUM condition
Of what microbial actions can antimicrobial drugs, radiation, formaldehyde, ethylene oxide can do to hinder ?
Cellular synthetic processes
Alcohols, phenols, acids, heat can interefere at where to prevent protein activities?
ribosome
3 different ways o hinder enzyme activity
1.denaturation of protein through heat+ pH
2.different shape from heat + pH
3. blocked Active site from heavy metal
Thermal death time/ Thermal death point is required to kill all test microbes/ all microbes
thermal death time-all test microbes
moist heat methods
steam under pressure
denatures proteins, destroys membranes and DNA
For canned food, what heat method is used?
Tyndallization: nonpressurized, disinfectant. Inermittant sterilization
This heat method is to kill potential agents of infection and spoilage without destroyng the food value
Pasteurization. not sterilization; disinfectant
Radiation
deep penetrating power to break DNA.
(electrons leave their orbit)
What rays can be used for radiation?
Gamma, X, cathode
What is used to sterilize medical suplies and food product?
radiation
Radiation causes DNA to form what dimer?
Thymine dimer
Aldehydes, Dyes, Gases, Hydrogen peroxide, chlorhexidine, phenolics, halogens can also contribue to germicidal?
yes
Which is prefered drug: Microbicidal or Microbistatic?
microbicidal
soluble or insoluble drugs are preferred?
Soluble : highly dilutedi in body fluids
Antibiotics
common metabolic products of aerobic sporeforming bacteria and fungi
Which is not antibiotic?
Streptomyces
Penicillium
Cephalosporum
Bacillus
Staphylococcus
staphylococcus
Microbes that engage in mutual or commensal associations
normal/ resident flora
indigenous flora
microbiota
pathogenic microbes penetrate host defenses, enter tissues and multiply to make this condition
infection
microbes penetrate and disrupt a tissue
disease
where in our bodies is microe free?
internal organs and tisuses and fluids
Arthropods are resident flora
yes
Where in our bodies has the largest number of bacteria?
large intestine
Bacterial flora can help preventing overgrwth of harmful microbes. This is called
microbial antagonism
Mostly where do we have resident microbes?
areas contact with outside environment
any chemical used in the treatment, relief, prophylaxis of a disease
chemotherapeutic drug
use of a drug to prevent IMMINENT infection of a person at risk
prophylaxis
the use of chemotherapeutic drugs to control infection
antimicrobial chemotherapy
any antimicrobial drug (inclusive term)
antimicrobials
This is from microorganisms' natural metabolic process that inhibit other microorganisms
antibiotics
This substance is modified from natural sources in the laboratory
semisynthetic drugs
Antimicrobial synthesized chemically in the laboratory
synthetic drugs
antimicrobials for a limited range of microbial types
narrow spectrum
what antimicrobialsare against gram negative and positive bacteria are
broad spectrum
penicillin, cephalosporins, vancomycin, bacitracin, monobactaria/carapenerns, fosfomycin, cycloserina, isoniazid
What do these do?
inhibit cell wall; block synthesis and repair.
what drug causes loss of selective permeability of cell membrane?
polymyxins
chloramphenoid, Erythromycin, Clandamycin, Oxizolidinones work at the side of where?
50S subunit of ribosome
What are the drugs that work at the site of 30S subunit of ribosome?
aminoglycosides, tetracyclines,streptomycin, amikacin
What drugs block pathways and inhibit metabolism?
sulfonamides(sulfa drugs) trimethoprim