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44 Cards in this Set
- Front
- Back
Sterilization
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destroys all viable microbes: viruses and endospores
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Disinfection
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destroy VEGETATIVE pathogens
inamnimate objects |
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Antiseptic:
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disinfectant applied to exposed body surfaces
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Sanitization
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mechanically removing microbes: cleansing technique
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Degermination
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REDUCING number of microbes
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Microbial death
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permanent loss of reproductive capability- even under OPTIMUM condition
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Of what microbial actions can antimicrobial drugs, radiation, formaldehyde, ethylene oxide can do to hinder ?
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Cellular synthetic processes
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Alcohols, phenols, acids, heat can interefere at where to prevent protein activities?
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ribosome
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3 different ways o hinder enzyme activity
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1.denaturation of protein through heat+ pH
2.different shape from heat + pH 3. blocked Active site from heavy metal |
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Thermal death time/ Thermal death point is required to kill all test microbes/ all microbes
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thermal death time-all test microbes
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moist heat methods
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steam under pressure
denatures proteins, destroys membranes and DNA |
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For canned food, what heat method is used?
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Tyndallization: nonpressurized, disinfectant. Inermittant sterilization
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This heat method is to kill potential agents of infection and spoilage without destroyng the food value
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Pasteurization. not sterilization; disinfectant
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Radiation
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deep penetrating power to break DNA.
(electrons leave their orbit) |
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What rays can be used for radiation?
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Gamma, X, cathode
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What is used to sterilize medical suplies and food product?
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radiation
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Radiation causes DNA to form what dimer?
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Thymine dimer
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Aldehydes, Dyes, Gases, Hydrogen peroxide, chlorhexidine, phenolics, halogens can also contribue to germicidal?
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yes
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Which is prefered drug: Microbicidal or Microbistatic?
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microbicidal
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soluble or insoluble drugs are preferred?
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Soluble : highly dilutedi in body fluids
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Antibiotics
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common metabolic products of aerobic sporeforming bacteria and fungi
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Which is not antibiotic?
Streptomyces Penicillium Cephalosporum Bacillus Staphylococcus |
staphylococcus
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Microbes that engage in mutual or commensal associations
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normal/ resident flora
indigenous flora microbiota |
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pathogenic microbes penetrate host defenses, enter tissues and multiply to make this condition
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infection
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microbes penetrate and disrupt a tissue
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disease
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where in our bodies is microe free?
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internal organs and tisuses and fluids
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Arthropods are resident flora
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yes
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Where in our bodies has the largest number of bacteria?
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large intestine
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Bacterial flora can help preventing overgrwth of harmful microbes. This is called
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microbial antagonism
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Mostly where do we have resident microbes?
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areas contact with outside environment
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any chemical used in the treatment, relief, prophylaxis of a disease
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chemotherapeutic drug
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use of a drug to prevent IMMINENT infection of a person at risk
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prophylaxis
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the use of chemotherapeutic drugs to control infection
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antimicrobial chemotherapy
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any antimicrobial drug (inclusive term)
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antimicrobials
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This is from microorganisms' natural metabolic process that inhibit other microorganisms
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antibiotics
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This substance is modified from natural sources in the laboratory
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semisynthetic drugs
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Antimicrobial synthesized chemically in the laboratory
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synthetic drugs
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antimicrobials for a limited range of microbial types
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narrow spectrum
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what antimicrobialsare against gram negative and positive bacteria are
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broad spectrum
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penicillin, cephalosporins, vancomycin, bacitracin, monobactaria/carapenerns, fosfomycin, cycloserina, isoniazid
What do these do? |
inhibit cell wall; block synthesis and repair.
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what drug causes loss of selective permeability of cell membrane?
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polymyxins
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chloramphenoid, Erythromycin, Clandamycin, Oxizolidinones work at the side of where?
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50S subunit of ribosome
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What are the drugs that work at the site of 30S subunit of ribosome?
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aminoglycosides, tetracyclines,streptomycin, amikacin
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What drugs block pathways and inhibit metabolism?
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sulfonamides(sulfa drugs) trimethoprim
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