Microbiology Exam 1 Set 5

Front 1

Heavy chain variability

_____ (#)variable region segments
____(#)diversity regions
____(#)joining segments
____(#) constant regions

Back 1

Heavy chain variability

__200___ (#)variable region segments
50(#)diversity regions
_4 (#)joining segments
__5__(#) constant regions

Front 2

____ induced unresponsiveness to certain antigens
-clonal anergy and anergized cells

Back 2

immune tolerance

Front 3

what is administered to pregnant women that is also known as anti-Rh

Back 3

rhogam

Front 4

what type of hypersensitivity includes these examples?

-tuberculin response
-allergic contact dermatitis
-graft rejection
-graft versus host disease

Back 4

type IV (delayed or Cell-mediated) hypersensitivity

Front 5

what type of hypersensitivity is due to the formation of antigen-antibody complexes, also called immune-complexes

Back 5

type III (immune_complex mediated) hypersensitivity

Front 6

what type of hypersitivity causes inflammation due to contact with certain antigens after 12-24 hours?

Back 6

type IV (delayed or cell-mediated) hypersensitivity

Front 7

what type of hypersensitivity can cause systemic and localized reactions?

Back 7

type III (immune-complex mediated) hypersensitivity:

Systemic-
-systemic lupus erythematosus
-rhematoid arthritis

Localized-
-hypersensitivity pneumonitis
-glomerulonephritis

Front 8

Type IV (delayed or Cell-mediated) hypersensitivity:

delay in the response reflects the time it takes for ___ and ___ to migrate to and proliferate at the site of the antigen

Back 8

macrophages and T cells

Front 9

what type of hypersensitivity results in Allergic contact dermatitis?

Back 9

type IV (delayed or cell-mediated) hypersensitivity

Front 10

what is the name of the antigen involved in the tuberculosis?

Back 10

M. tuberculosis

Front 11

tuberculin response is mediated by ____

Back 11

memory T cells

Front 12

___ is a cell-mediated immune response resulting in an intensely irratating skin rash

Back 12

allergic contact dermatitis

-response triggered by chemically modiied skin proteins that the body regards as foreign
-can happen when a hapten, such as the oil from poison iy and related plants, binds to proteins on the skin

Front 13

what can be used to treat allergic contact dermatitis?

Back 13

coritcosteroids

Front 14

Graft-verse-host Disease

if donor and recipient differ in MHC class II, then grafted ___ cells attack the antigen-presenting cells of the host

Back 14

T-cells

leads to immunosuppression

Front 15

If donor and recipient differ in MCH class __ molecules, the grafted T cells attack all of the recipient's tissues

Back 15

MCH class II

Front 16

categories of autoimmune diseases:

what are the two major catagories?

Back 16

Single tissue diseases and systemic diseases

Front 17

categories of autoimmune diseases:

what tissues/cells/glands are effected by single tissue diseases?

Back 17

blood cells, endocrine glands, and nervous tissue

Front 18

categories of autoimmune diseases:

what types of diseases are a result of systemic autoimmune diseases?

Back 18

systemic lupus erythematosus and rheumatoid arthritis

Front 19

there are two things that cause the systemic effects of systemic lupus erythematosus and rhematoid arthritis....what are they?

Back 19

type III (immune-complex mediated) hypersensitivity

and

systemic autoimmune disease

Front 20

autoimmunity affecting blood cells:

production of autoantibodies to leukocytes makes what difficult?

Back 20

combating infections

Front 21

autoimmunity affecting blood cells:
production of autoantibodies to RBCs results in what ?

Back 21

hemolytic anemia and it also causes destruction of RBC by phagocytic cells or complement system activation

Front 22

autoimmunity affecting blood cells:
production of autoantibodies to blood platelets causes what?

Back 22

blood does not clot

Front 23

autoimmunity affecting endocrine organs:

what disease causes these effect:

-autoantibodies bind cells in the anterior pituitary gland
-stimulated cells produce thyroid stimulating hormone
-results in excessive production of thyroid hormone and growth of the thyroid gland

Back 23

Grave's disease

Front 24

autoimmunity affecting endocrine organs:

what disease causes these things:

- results from the inability to produce insulin
-some cases develop following a viral infection or in people with a genetic predisposition

Back 24

Type I diabetes

Front 25

what cells in the pancreas are effected during type I diabetes?

Back 25

islet of langerhans

Front 26

what gland is affected during Grave's disease

Back 26

thyroid gland

Front 27

Autoimmunity affecting Nervous tissue:

what disease causes these effects:

cytotoxic T cells attack and destroy myelin sheath
-results in deficits in vision, speech, and neuromuscular function
-may be triggered by a viral infection

Back 27

multiple sclerosis

Front 28

what results from a type III hypersensitivity reaction where B cells in the joints produces autoantibodies agains collagen that covers joint surfaces

Back 28

rheumatoid arthritis

Front 29

in immunodeficiency diseases, what type occurs early in life, and is a result from some genetic or developmental defect?

Back 29

primary

Front 30

in immunodeficiency diseases, what type develops later in life, is caused by severe stress?

Back 30

acquired

Front 31

immunodeficiency diseases:

Acquired:

suppression of cell-mediated immunity results from an excess production of ___

Back 31

corticosteroids , which is toxic to T cells

Front 32

___ is the study and diagnostic use of antigen-antibody interactions in blood serum

Back 32

serology

Front 33

what test is described :

antibodies bind to binding site of the virus so the virus can no longer attach to cell

a-precipitation test
b-agglutination tests
c- neutralization tests
d-complement fixation test
e-various tagged antibody tests

Back 33

neutralization test

Front 34

what test is described:

attached antibodies to the surface of cell, add complement, if antibody did attach the complement would be activated and lyse the cell

a-precipitation test
b-agglutination tests
c- neutralization tests
d-complement fixation test
e-various tagged antibody tests

Back 34

complemen fixation test

Front 35

what portion of the antibody is always labeled?

Back 35

Fc portion

Front 36

____=when antibodies and antigens combine, forms in equivalence zone percipitate forms which promotes phagocytosis and inflammation

Back 36

lattice

Front 37

___ is the clumping of insoluble particles

Back 37

agglutination

Front 38

what test is described :

antibodies bind to binding site of the virus so the virus can no longer attach to cell

a-precipitation test
b-agglutination tests
c- neutralization tests
d-complement fixation test
e-various tagged antibody tests

Back 38

neutralization test

Front 39

what test is described:

attached antibodies to the surface of cell, add complement, if antibody did attach the complement would be activated and lyse the cell

a-precipitation test
b-agglutination tests
c- neutralization tests
d-complement fixation test
e-various tagged antibody tests

Back 39

complemen fixation test

Front 40

what portion of the antibody is always labeled?

Back 40

Fc portion

Front 41

____=when antibodies and antigens combine, forms in equivalence zone percipitate forms which promotes phagocytosis and inflammation

Back 41

lattice

Front 42

___ is the clumping of insoluble particles

Back 42

agglutination