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30 Cards in this Set
- Front
- Back
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3 adesins for gram neg
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pili, surface proteins and capsules
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2 adesins for gram pos
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surface proteins and capsules
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2 receptors for gram neg adesins
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cell structures and integrins
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receptor for gram pos adesins
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fibronectin
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which gram neg adhesin recognizes integrin?
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invasin
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what is fibronectin important for?
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selecting normal flora
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3 means by which bacteria steal body Fe
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chelating compounds, steal directly from binding proteins, lysotoxin to RBC
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means to defend against complement
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masking (capsule, sialic acid), apply inhibitors (factor H, C4bp), cover MAC targets, inactivate C5a
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"smooth" strains that are resistant to MAC have what?
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long O antigen chains
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means of subverting phagocytosis
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inhibit recruitment and function, leukocidin killing, escaping ingestion, killing after ingestion
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means of inhibiting phagocyte recruitment of function
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prevent compliment activation, secrete toxin to increase cAMP, produce C5a to inactivate C5a chemokine
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means of killing phagocytes
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leukocidin, injection of protein to alter phagocyte response
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means of escaping ingestion
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capsule and protein A
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what does protein A bind?
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the Fc portion of IgG which inhibits binding by Fc portion of phagocyte
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what organism increases cAMP?
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Bordatella pertussis
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what organism produces C5a?
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group A strep
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what 4 organsims secrete leukocidins?
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pseudomonads, staph, group A strep, clostridia
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which 3 organisms can escape into the cytoplasm after ingestion?
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listeria, shigella, rickettsiae
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which organism is resistant to lysosomal enzymes?
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leishmania
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which 2 organisms inhibit phagocyte oxidative path?
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legionella and staph
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which 3 organisms induce formation of syncitia and multinucleated giant cells to allow transmission to other cells?
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HSV, varicella, resp syncititial
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which organsim uses cytoskeleton to transmit directly to other cells?
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shigella
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which 3 organisms can change their antigenic coats?
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trypanosomes (sleeping sickness), gonococci, influenza
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does antigenic variation occur in the individual with influenze virus?
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no
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antigenic drift involves what size changes every how many years?
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minor; 2-3 years
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antigenic shift involves what size changes every how many years?
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major; 10 years
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what 2 proteins are adapted in antigenic variation of influenza? what are their functions?
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hemagglutinin which binds to cell receptors; neuraminidase which changes the receptors
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what 4 bacteria make proteases for IgA?
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gonococci, meningiococci, haemophilus influenza and dental strep
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what is fabulation?
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cleaving of IgA causes the fab portion of the Ab to stay attached to the bacteria which protects it from future Ab binding
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what is the function of staphylokinase? why is the usefule?
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cleaves host plasminogen; plasmin then cleaves IgG and C3b
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