Microbiology Block 2 Rickettsia, Xoxiella, Ehrlichia, Bartonella

Front 1

general chracteristics of Rickettsia, xociella, Ehrilichia, and Bartonella

Back 1

very mally bacillus, aerobic, weakly Gram negative, Giemasa stain

Front 2

R. rickettsii virulence factor

Back 2

obligate intracellular parasite

Front 3

pathophysiology of R. rickettsii

Back 3

inoculation via antropd vector --> local invastion and replication --> widespread dissemination. tissue injury due to replication in vascular endothelium

Front 4

reservoir of R. rickettsii

Back 4

rodents + ticks

Front 5

disease of R. rickettsii

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Rock mount spotted fever - acute onset. classic triad: fever, headache, rash. macular to petechial rash with centripetal spread. rash begins at ankles then goes to trunk

Front 6

lab diagnosis of R. rickettsii

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Weil-felix reaction (agglutination tests), specific serology,indirect fluorescent antibody, direct visualization, culture (difficult and slow)

Front 7

treatment of R. rickettsii

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tetracycline and chloramphenicol (doxycline)

Front 8

virulence factor R. akari

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obligate intracellular parasite

Front 9

reservoir of R. akari

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mouse + mite

Front 10

disease of R. akari

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rickettial pox. classies triad with papulovesicular rash. infection is biphasic - mild febilre illness --> sever fever and headaches

Front 11

lab diagnosis of R. akari

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weil-felix reaction, IFA, direct visualization, PCR

Front 12

treatment of R. akari

Back 12

tetracyline (doxycline) or chloramphenicol

Front 13

virulence factor of r. prowazekii

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obligate intracellular parasite

Front 14

reservoir of R. prowazekii

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human body louse

Front 15

disease of R. prowazekii

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epdiemic typhus/louse borne typhus: acue onset of classic triad with maculopapular rash 91st drunk then body), lots of complications
Brill-zinsser disease - reccurent epdiemic typhus

Front 16

lab diagnosis of R. prowazekii

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weil-felix reaction, IFA, direct visualization, PCR

Front 17

treatment of R. proawazekii

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tetracyline (doxycline) or chloramphenicol

Front 18

prevention of R. prowazekii

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vaccine: formaldehyde-inactivated R. prowazekii or live/attenuated strain

Front 19

virulence factor of R. typhi

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obligate intracellular parasite

Front 20

reservoir of R. typhi

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rodents + flea

Front 21

disease of R. typhi

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gradual triad + nausea, may or may not have rash

Front 22

lab diagnosis of R. typhi

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weil-felix, IFA, direct visualization, PCR

Front 23

treatment of R. typhi

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tetracyline (doxycline) or chloramphenicol

Front 24

virulence factor of C. brunetii

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obligate intracellular spores antigenic variation

Front 25

pathophysiology of C. burnetii

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transmission via inhalation or ingestion of contaminated milk no vector

Front 26

reservoir of C. burnetii

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animals, sheep, spores in soil

Front 27

diseases of C. burnetii

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Q fever- acute - triad respiratory sytmptoms no rash
chronic - aubacute endocarditis, 50 percent asymptomatic, only ricksettia that cause peneumo and no rash

Front 28

lab diagnosis of C. burnetii

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serology, PCR

Front 29

treamtne of C. burnetii

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acute - tetracycline
chronic - ramfpcin + tetracycline or TMPSXT

Front 30

virulence of E. chaffeensis

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obligate intracellulr parasite

Front 31

reservoir of E. chaffeensis

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deer + tick

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disease of E. chaffeensis

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chrichiosis: ferve headache, malaise, myalgia, no rash
lecuopenia (low WBC) and thormbocytopenia (low platelets)
monocytic ehrilichiosis infects moncytes in blood and tissue
grandulocytic ehrlichiosis - infection of granulocytes

Front 33

lab diagnosis of E. chaffeensis

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IFA, PCR, direct visualization, blood smear

Front 34

treatment of E. chaffeensis

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tetracyline (doxycline)

Front 35

virulence factors of B. henselae

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not an obligate intracellular parasite

Front 36

pathophysiology of B. henselae

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bartonella gives rise to angioproliferative lesions

Front 37

reservoir of B. henselae

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cats + cat flea

Front 38

disease of B. henselae

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cat scratch disease - inital pustule/capsule --> fever, malaise --> lymhadenophathy
unusual manisfestations: perinauds oculoglandular syndrome, encephalitits, hepatitits
associated disease states - angiomatosis, bacillary peliosis hepatitis, relapsing fever with bacteremia

Front 39

lab diagnosis of B. henselae

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culture, serology, histology, PCR

Front 40

treatment of B. henselae

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CSD: rifampin, ciproflaxacin, TMP-SXT, gentamicin, doxycline

Front 41

virulence factor of B. quintana

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not an obligate intracellular paraiste

Front 42

disease of B. quintana

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trench fever - persistent/recurrent fever, headache, weakenss, mylagia, no rash, point pain

Front 43

lab diagnosis of B. quintana

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serology, PCR

Front 44

treatment of B. quintana

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tetracycline or chloramphenicol

Front 45

reservoir of B. quintana

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human body tissue (the homeless)