Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
shape Clostridium perfringens
|
bacillus "box car" shaped
|
|
|
fermenting C. perfringens
|
stormy fermentation = gas production. sweet smelling
|
|
|
virulence factros of C. perfringens
|
alpha toxi (hemolysin), enterotoxin
|
|
|
pathophysiology C. perfringens
|
wound infections, ingestion of spores, trauma/surgery
|
|
|
reservoir C. perfringens
|
soil, human GI tract
|
|
|
disease C. perfringens
|
common cause of gas gangrene
|
|
|
spcimen of C. perfringens
|
pus, infected tissue
|
|
|
lab diagnosis c. perfringens
|
double zone of hymolysis. lecithinase positive on egg yolk agar
|
|
|
treatment C. perfrigens
|
debride devitalized tissue + penicllin G
|
|
|
virulence factor C. difficile
|
heat-labile enterotoxin
|
|
|
pathophysiology C. difficile
|
transmitted via spores. antibiotics destroys normal guy flora allowing it to grow
|
|
|
reservoir C. difficile
|
colon
|
|
|
diseases C. difficile
|
pseduomembranous enterocolitis with diarrhea
|
|
|
specimen of C. dificile
|
stool (detected toxin, not organism)
|
|
|
lab diagnosis of C. dificile
|
cycloserine - cefoxitin-fructose agar
|
|
|
treatment C. dificile
|
discontinue antibiotics of possible, metronidazole or vacomycin
|
|
|
temperature of C. botulium
|
spores resist boiling
|
|
|
general characteristics of Clostridium
|
gram positive bacillus, spores forming
|
|
|
virulence factors of C. botulinum
|
seven typles of neurotoxins (A, B, E cuase most human disease)
toxins resitant to destruction by intestinal enzymes, and act at the NMJ by inhibiting Ach release --> flaccid paralysis |
|
|
pathophysiology of C. botulinum
|
spores get into food or wounds. home canning. honey risk for babies
|
|
|
diseases of C. bolulinum
|
botulism: food borne, wound, infant
|
|
|
lab diagnosis of C. botulinin
|
lipase and lechithinase positive
|
|
|
treatment for C. botulinum
|
anti-serum for toxin itself, antibiotics for wound botulism
|
|
|
aerobocity of C. tetani
|
strictly anaerobic
|
|
|
spores of C. tetani
|
tennis racket chaped
|
|
|
virulence factors of C. tetani
|
tetanospasmin (neurotixic endotoxin) suppresses release of inhibitory NT's
|
|
|
pathophysiology of C. tetani
|
deep puncture wounds --> local environment at point of inoculation must be a very low reox potential
|
|
|
disease of C. tetani
|
tetanus: lockjaw (trismus), spamic paralysis
|
|
|
lab diagnosis C. tetani
|
confirmation depeonds on deonstration of neurotoxin production
|
|
|
treatment of C. tetani
|
tetanus immunoglobulin. penicillin g to prvent release of additional toxin
|
|
|
propionibacterium acnes
|
commonly found on skin
|
|
|
Lactobacillus spp.
|
colonizes human vagina, rarely pathogic
|
|
|
mobiluncus
|
female GU tract, bacterial vaginosis
|
|
|
Eubacterium, bifidobacterium, Rothia spp.
|
rarely cause disease
|
