Microbiology: Antigens And Antibodies, Block 1

Front 1

A single IgG has either two kappa or two lambda ______ _____, never mixed.

Back 1

Light chains

Front 2

The antigen binding site is formed by the ________ ______ of both the light and heavy chains.

Back 2

Variable regions.

Front 3

The specificity of the antigen binding site is a function of the amino acid sequence of the ________ _________.

Back 3

Hypervariable Regions

Front 4

The ______ ends are different in secreted and bound Ig heavy chains.

Back 4

COOH

Front 5

The 3 hypervariable regions in both heavy and light chains at the NH2 terminus serve as what?

Back 5

Antigen contact points

Front 6

Specific regions in the constant region of heavy chains that defines the heavy chain class.

Back 6

Antigenic determinants (IgM, IgG, IgA, etc.)

Front 7

Each _____ is encoded by a separate constant region gene.

Back 7

Isotype

Front 8

Which class of immunoglobulins is most plentiful and has the longest half life?

Back 8

IgG

Front 9

This immunoglobulin has minor functions and is coexpressed with IgM in primary immune response:

Back 9

IgD

Front 10

This immunoglobulin is responsible for the allergic response:

Back 10

IgE

Front 11

Allergen cross linkage of receptor-bound IgE, on _____ cells induces degranulation and allergic response.

Back 11

Mast Cells

Front 12

Individual specific determinants on constant regions of antibodies from individuals of the same species

Back 12

Allotypes

Front 13

Can react with a specific antibody but cannot induce the immune response. Can induce the immune response when bound to carrier proteins.

Back 13

Hapten

Front 14

What interaction with T cells is required for both humoral and cell mediated reactions

Back 14

Interaction of T cell with antigen bound to MHC