Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/18

Click to flip

18 Cards in this Set

  • Front
  • Back
Rifampin
binds to the RNA polymerase closed complex

prevents the initiation of transcription
Common Antibiotic target
Bacteria ribosome

-bacteria ribosome significantly differs from the human ribosome, therefore it is a target of numerous antibiotics
Aminoglycosides
interact w/ the 16S rRNA in the 30S subunit of the ribosome

prevents the binding of f-Met(formyl-methionine), which is the 1st amino acid of most bacterial proteins

require oxidative phosphorylation for transport, which requires a proton motive force, so they require a transmembrane potential

intestinal tract normal flora unaffected (b/c of use of fermentation for energy and weak membrane potentials)
Tetracyclines
interact w/ 23S rRNA in the 30S subunit

block the transfer of tRNA's into the acceptor site
Chloramphenicol & Licosamides
interact w/ the 50S subunit

inhibit the formation of peptide bonds (peptidyl transfer)
Macrolides
interact w/ the 23S rRNA in the 50S subunit

cause the release of the growing polypeptide chain
Streptogramins
block the P-site, therefore blocking the translocation of the growing peptide to the P-site to restart the cycle
Azithromycin
erythromycin derivative w/ a methyl substituted lactone ring
Oxazolidinines
prevent the formation of the f-Met-mRNA-30S subunit ternary complex

active against:
methicillin resistant Staphylococcus

multiresistant Streptococci pneumoniae

vancomycin resistant enterococci
Phosphomycin/Fosfomycin
is PEP analog that inhibits the synthesis of NAM from NAG
D-Cycloserine
an analog of D-Ala and inhibits the racemase reaction and addition of D-Ala to the AA1-AA2-AA3 chain
Bacitracin
binds undecaprenyl-PP and inhibits recycling of the carrier
Vancomycin
glycopeptide antibiotic that binds D-Ala D-Ala and sterically hinders PbP's from carrying out transpeptidation reactions
B-lactams
are structurally related to D-Ala adn tightly bind PBP's inhibiting their transglycosylation and transpeptidation activity
Polymyxin
disrupts bacterial membrane causing release of cytoplasmic components

will destroy non-growing(non-replicating) cells

more effective against Gram negative bacteria b/c they have a higher affinity for LPS and phosphotidylethanolamine
Quinolones

Floroquinolines
bind DNA gyrase-ATP complex thus blocking transcription and DNA replication
Sulfonamides
are a PABA analog that inhibit the TFA biosynthetic pathway
Trimethoprim
binds dihydrofolate reductase thus inhibiting the TFA biosynthetic pathway