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19 Cards in this Set
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relapsing and remitting fever
protozoa that grows in the liver and then invades RBCs and lyses at different intervals fever, chills and sweating in 48-72 hour cycles can result in anemia from RBC lysis and sticky RBCs--> clots |
Malaria
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plasmodium species that produce dormant forms that live in the liver
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plasmodium vivax and plasmodium ovale
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species of plasmodium that causes continuous fever and is the most deadly
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plasmodium falciparum
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treatment for malaria
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chloroquine and primiquine
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cerebral malaria
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seizures, impaired conciousness, coma, death in person with malaria (usually young kids- subsaharan africa)
even with tx 20% die |
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why do hepatomegaly and splenomegaly occur with malaria
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RBC lysis leads to phagocytes clearing the debris and bringing it back to the liver and spleen-- spleen filters out damaged RBCs
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protection against plasmodium vivax and plasmodium falciparum
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p. vivax- genetic absence of duffy a and b antigens on RBC membranes-that protozoa binds to
p. flaciparum- sickle cell anemia |
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if plasmodium species is resistant to cloroquine, what is second line tx
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mefloquine or quinine
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for p. vivax and p. ovale, what must be given in addition to chloroquine to kill dormant malaria cells in the liver
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primaquine
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what is the insect vector for malaria?
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anopheles mosquito
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disease causing maltese cross seen within RBC
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babesia microti
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two species that produce ring shaped trophozoites inside RBC
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plasmodium (malaria) and babesia microti (look for maltese cross to identify babesia)
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what transmits babesia microti?
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Ixodes tick
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how is leishmania transmitted to humans?
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sandfly bite
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hepatomegaly and MASSIVE SPLENOMEGALY
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leishmania
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what transmits trypansoma brucei to humans?
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tsetse fly
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recurring fevers (relapsing and remitting on cycle of about a mo) followed by neurological sx of daytime sleepiness, behavioral changes, coma and death
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trypansoma brucei- african sleeping sickness
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what causes recurring/ relapsing/remitting fever in trypansoma brucei?
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variable surface glycoproteins
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cause of Chagas disease?
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trypansoma cruzi
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