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10 Cards in this Set
- Front
- Back
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This first line drug for Malaria prevents heme metabolism. It is used as prophylaxis and only treats the blood forms only.
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CHLOROQUINE
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This anti-malarial is used to treat P. Falciparum resistant strains and has an unknown MOA.
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MEFLOQUINE
Falciparum resistant prophylaxis |
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This anti-malarial blocks DNA replication and is used for the tx of resistant falciparum. It is contraindicated in pregnancy.
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QUININE
Tx of blood forms only. Often used with doxycyline or clindamyin to shorten duration and limit toxicity. Causes Cinchonism = GI, Headache, vertigo, blurred vision and tinnitus. |
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This anti-malarial works by inducing oxidative stress and as a result causes methemoglobinemia. Used to treat hiding tissue forms = hypnozoites.
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PRIMAQUINE
Contraindicated in pregnancy. |
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This antibacterial drug is a 30S inhibitor and is used in malaria prophylaxis especially against resistant Falciparum.
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DOXYCYLINE
Contraindicated in pregnancy |
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This anti-protozoal has many uses, including anti-bacterial, and treats Bowel wall and Liver invaders.
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METRONIDAZOLE
Giardia, Entameoba, Trichomonas C.Difficile, B.Fragillis H.Pylori GI + Metallic taste |
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This drug is used as an alternative agent to treat PCP, Trypanosoma Brucei, and Leshmaniaisis.
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PENTAMIDINE
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This drug is first choice for prophylaxis and tx of PCP, Toxoplasmosis and Isosproa belli.
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TMP-SMX
Toxicity:neutropenia, thrombocytopenia |
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Primary drug used for acute attacks and prophylaxis of malarial infection, although resistance is common.
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CHLOROQUINE
This drug kiss parasites within erythrocytes (schizonticidal) it disrupts hemoglobin breakdown, with the accumulation of heme, which is toxic to the organism. |
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Used for the tx of chloroquine-resistnat malarialinfection due to P. falciparum.
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QUININE
Blocks DNA replication and RNA transcription in P.falciparum within erythrocytes; a common side effect is cinchonism, a constellatin of sx including headace, vertigo, blurred vision, and tinnitus; a related drug, MEFLOQUINE, has fewer side effects and is used as prophylaxis in chloroquine resistant areas. |
