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11 Cards in this Set
- Front
- Back
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Tx for Onchocerca Volvulus and other Filariae Tissue Nematodes.
MOA:Increases GABA = paralysis and death. |
IVERMECTIN
Also causes Mazotti Rxn: Fever, rash, hypotension, Arthalgias, Vertigo. Tx: Antihistimines + NSAIDS |
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These drugs act to inhibit microtubule synthesis and function causing decreased absorbtion and secretion. Used for the Tx of Intestinal Nematodes.
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MEBENDAZOLE
ALBENDAZOLE Contraindicated in pregnancy. |
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Activates Nicotinic receptors = paralysis via neuromuscular blockade. Used for Tx of Intestinal Nematodes. Is a CIDAL drug.
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PYRANTEL PAMOATE
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Used in the Tx of Cestodes and Trematodes, this drug increases calcium = contraction and paralysis and also increases LFT's. Often used with Niclosamide.
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PRAZIQUANTEL
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Acts as an uncoupler of Ox Phos or by activating ATPases to stop ATP production = Death.
Used in the Tx of Cestodes and Trematodes along with Praziquantel. |
NICLOSAMIDE
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Unknown MOA this drug is the drug of choice in Loa Loa and W. Bancrofti infections.
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DIETHYLCARBAMAZINE
Also causes Mazotti Rxn: Fever, rash, hypotension, Arthalgias, Vertigo. Tx: Antihistimines + NSAIDS |
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Antihelminthic agent used for the tx of river blindness (caused by Onchocerca volvulus) and threadworm infection (Strongyloides stercoralis)
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IVERMECTIN
Incrases GABA mediated neurotransmission, but since it does not cross the human BBB, it selectively affects the nematode, resulting in paralysis of the worm. |
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Used for the tx of many helminth infections, it is the drug of choice for pinworms, the most common helminth infection in the US.
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MEBENDAZOLE
Functions by inhibiting microtubule synthesis and glucose uptake in helminths; related drugs such as albendazole and thiabendazole are the alternatives. |
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Trypanosomiciadal drug used for the tx of Chagas disease.
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NIFURTIMOX
Drugs used to treat African trypanosomiasis include PENTAMIDINE, SURAMIN and MELARSOPROL |
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Primary drug used for the tx of trematode (fluke) and cestode (tapeworm) infections.
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PRAZIQUANTEL
Increases calcium permeability in the worm, resulting in paralysis; NICLOSAMIDE, which functions by uncoupling oxidative phaosphorylation (inhibiting ATP production) or by activating ATPases, often in used with PARZIQUANTEL in cestode infections. |
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Antihelminthic agent, often used with Mebendazole for the tx of roundworm, pinworm, and hookworm infections.
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PYRANTEL PAMOATE
Stimulates nicotinic receptors in the nematode, resulting in a spastic paralysis. |
