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22 Cards in this Set

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Transplacental infection can result in a triad of interstitial keratitis, Hutchinson teeth, and 8th CN deafness.
Treponema Pallidum
Infection results in osteochondritis and periostitis and contributing as well to other defects such as destruction of the vomer leading to a saddle nose deformity, mulberry molars and saber shins.
Treponema Pallidum
Long-term consequences of untreated disease include Tabes Dorsalis and aneurysms of the ascending aorta.
Treponema Pallidum
Tertiary syphilis can lead to paresis and is the leading cause of aneurysms of the ascending atorta with a characteristic tree-barking appearance.
Treponema Pallidum
The disease can manifest with a maculopapular rash on the palms and soles, and condyloma lata.
Treponema Pallidum
Secondary syphilis preesents with a rash and gray flattened wart-like lesions on the anogenital, axillary, and oral areas; these condyloma lata are not to be confused with condyloma acuminatum seen with HPV infection.
Treponema Pallidum
Initial infection presents with a painless ulcer on the genitals known as a chancre.
Treponema Pallidum
The characteristic lesion of primary syphilis is highly contagious and contains numerous spirochetes viewed by dark field light microscopy or by immunofluorescent microscopy.
Treponema Pallidum
Patients with SLE are often positive for serologic tests for this organism even if not infected.
Treponema Pallidum
Screening test like the rapid plasma reagin or venereal disease research laboratory VDRL are based on finding antibodies to cardiolipin, which patients with SLE make; the most specific test is the fluorescent treponemal antibody FTA-Abs test.
Treponema Pallidum
The orgainaism is exquisitely sensititve to penicillins; treatment can result in rash, fever, and hypotension (Jarisch-Herxheimer Reaction)
Treponema Pallidum

Tx results in rapid death of the organism with the release of toxic products that cause symptoms that can be relieved b anti-inflammatory agents.
Transmitted by the Ixodes tick bite that results in a characteristic bull's eye lesion (Erythema Chronicum Migrans)
Borrelia Burgdorferi

Infection occurs mainly in the NE during the summer months, when the deer tick Ixodes is found.
Late stages of infection may lead to a severe autoimmune arthritis, life-threatening heart block, and facial nerve palsy.
Borrelia Burgdorferi

The vaccine has recently become available for this organism, to prevent the development of Lyme disease.
Transmitted by the human body louse (lice), this organism causes relapsing fever.
Borrelia Recurrentis

Causes a febrile disease that fades as antibodies develop and relapses as the organism undergoes antigenic variation of its variable major protein.
Primary stage-painless chancre
Secondary stage
Rash palms/soles
Condyloma latum
CNS involvement
Latent stage
Tertiary stage
Gummas
Cardiovascular (aneurysm)
Neurosyphilis
Treponema Pallidum
This organism causes Lyme disease and is transmitted by the Ixodes tick with white footed mice and white tailed deer as the reservoir.
Borrelia Burgdorferi

Tx: Doxycylin, Penicillin
This organism causes 3 stages:
Localized - Erythema chronicum migrans + lymphadenopathy
Disseminated - skin, nerves, heart, joints
Late stage - chronic arthritis, encephalopathy
Borrelia Burgdorferi
This orgainsm is associated with chronic large joint arthritis and Bell's palsy
Borrelia Burgdorferi
Vaccines for this organism are ImuLyme and LYMErix.
Borrelia Burgdorferi
Transmission is via the body louse and evades immune system via antigenic variation while causing relapsing fever
Borrelia Recurrentis
This organism has 2 phases; the first involves fever and myalgia with red conjunctiva and photophobia. The second phase includes high IgM levels and neck pain.
Dx:
1 - CSF/Blood
2 - Urine
Leptospira Interrogans

Tx: Penicillin, Doxycyclin
Weils Disease
Jaundice, ARF, mental changes and organ hemhorrage

Transmission via animal urine.
Leptospira Interrogans