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23 Cards in this Set
- Front
- Back
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Paired, kidney bean shaped diplococci within leukocytes in a urethral discharge
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Neisseria Gonorrhoeae
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This gram - diplococci can only ferment Glucose
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Neisseria Gonorrhoeae
Glucose = Gonorrhoeae |
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Leading cause of Septic Arthritis - typically presents and nomoarticular arthritis of the knee, ankle or wrist after a bout with urethritis.
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Neisseria Gonorrhoeae
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STD that can lead to PID that then predisposes to ectopic preganancy - second most common notifiable disease in US.
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Neisseria Gonorrhoeae
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Infection of a neonate passing through an infected birth canal results in ophthalmia neonatorum and purulent conjunctivitis.
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Neisseria Gonorrhoeae
Tx: silver nitrate drops, tetracycline or erythromycin |
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This gram - diplococci bacteria can ferment Maltose and Glucose
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Neisseria Meningitidis
MeninGitidis = Maltose + Glucose |
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Leading cause of meningitis among military recruits and dormitory settings - caused by AB&C capsule antigens.
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Neisseria Meningitidis
No vaccine against B |
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Patients with deficiencies in the C6-9 complement components (MAC) are particularly susceptible to infection
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Neisseria Meningitidis
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Septicemia resulting from this organism can result in progressive hypotension, DIC, widespread vascular purpura and bilateral adrenal hemorrhage/insufficiency (Waterhouse-Fredrickson syndrome).
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Neisseria Meningitidis
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Tx for Neisseria Meningitidis + Tx for close contacts of infected patients.
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Tx: Pen G
3rd Generation Cephalosporins - Ceftriaxone Prophylaxis: Rifampin for close contacts Vaccine against Capsular ag = ACYW135 (NOT B) |
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Tx for Neisseria Gonorrhoeae Adult infection
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Tx: 3rd Generation Cephalosporin -Ceftriaxone
Add Doxycyclin to cover Chlamydia/Syphilis Second line not effective against Syphillis - Fluoroquinolones or Spectinomycin |
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Tx for Neisseria Gonorrhoeae Neonatal infection
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Prophylaxis: Erythromycin drops fight Gonorrhea + Chlamydia
Tx:Systemic Cephtriaxone + Erythromycin syrup to cover Chlamydia |
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When is a newborn suceptable to Neisseria Meningitidis and Haemophilus Influenzae?
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6monts - 2 yrs
During this time newborns do not produce their own abs. |
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Gram - diplococci transmitted via respiratory droplets
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Neisseria Meningitidis
Can live in the nasopharynx = carrier |
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Progression:
Fever-Petechial rash-hypotension-WHFS |
Neisseria Meningitidis
Endotoxin causes vascular necrosis. |
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Dx:
Growth on Thayer-Martin VCN Chocolate Augar Vancomycin (+) Colistin (-) Nystatin (Fungus) |
Neisseria Meningitidis + Neisseria Gonorrhoeae
Differentiate via metabolism glucose vs maltose fermentation |
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Clinical presentation of Meningitis in:
Infant: Older infant: |
Infant:bulging open anterior fontanel
Older infant: Stiff neck, + Kernig's/Brudzinski signs |
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Intravascular invasion causes fever and petichial rash.
Dissemination = meningitis or fulmanint WFS (hypotension + tachycardia) |
Meningococcemia = Petichia + Meningitis + WFS
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Dx: via blood, Petichiae or CSF
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Neisseria Meningitidis
Grow on Thayer-Martin VCN |
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Neisseria Meningitidis virulence factors
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Capsule - ABCDXYZW135 Antigens
Meningitis caused by ABC Endotoxin (LPS)- causes bv hemorrhage IgA1 Protease - cleaves IgA |
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Neisseria Gonorrhoeae virulence factors
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Pili - constantly changing
Protein II - Adherence factor |
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Men = urethritis (pain + pus)
Women = PID, Fitz Hugh Curtis both = Septic Arthritis Neonates = conjunctivits |
Neisseria Gonorrhoeae
Invades and hides within WBC's on biopsy. Look for Diplococci inside WBC's |
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Part of the normal respiratory flora
Kids - Otitis media Respiratory infections |
Branhamella Catarrhalis/
Neisseria Catarrhalis Beta lactam Resistant Tx:Azithromycin/Clarthiromyciin amoxicillin with clavulante 2/3rd Cephalosporin TMP-SMX |
