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23 Cards in this Set

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Paired, kidney bean shaped diplococci within leukocytes in a urethral discharge
Neisseria Gonorrhoeae
This gram - diplococci can only ferment Glucose
Neisseria Gonorrhoeae

Glucose = Gonorrhoeae
Leading cause of Septic Arthritis - typically presents and nomoarticular arthritis of the knee, ankle or wrist after a bout with urethritis.
Neisseria Gonorrhoeae
STD that can lead to PID that then predisposes to ectopic preganancy - second most common notifiable disease in US.
Neisseria Gonorrhoeae
Infection of a neonate passing through an infected birth canal results in ophthalmia neonatorum and purulent conjunctivitis.
Neisseria Gonorrhoeae

Tx: silver nitrate drops, tetracycline or erythromycin
This gram - diplococci bacteria can ferment Maltose and Glucose
Neisseria Meningitidis

MeninGitidis = Maltose + Glucose
Leading cause of meningitis among military recruits and dormitory settings - caused by AB&C capsule antigens.
Neisseria Meningitidis

No vaccine against B
Patients with deficiencies in the C6-9 complement components (MAC) are particularly susceptible to infection
Neisseria Meningitidis
Septicemia resulting from this organism can result in progressive hypotension, DIC, widespread vascular purpura and bilateral adrenal hemorrhage/insufficiency (Waterhouse-Fredrickson syndrome).
Neisseria Meningitidis
Tx for Neisseria Meningitidis + Tx for close contacts of infected patients.
Tx: Pen G
3rd Generation Cephalosporins - Ceftriaxone

Prophylaxis: Rifampin for close contacts
Vaccine against Capsular ag = ACYW135 (NOT B)
Tx for Neisseria Gonorrhoeae Adult infection
Tx: 3rd Generation Cephalosporin -Ceftriaxone
Add Doxycyclin to cover Chlamydia/Syphilis

Second line not effective against Syphillis - Fluoroquinolones or Spectinomycin
Tx for Neisseria Gonorrhoeae Neonatal infection
Prophylaxis: Erythromycin drops fight Gonorrhea + Chlamydia

Tx:Systemic Cephtriaxone + Erythromycin syrup to cover Chlamydia
When is a newborn suceptable to Neisseria Meningitidis and Haemophilus Influenzae?
6monts - 2 yrs

During this time newborns do not produce their own abs.
Gram - diplococci transmitted via respiratory droplets
Neisseria Meningitidis

Can live in the nasopharynx = carrier
Progression:

Fever-Petechial rash-hypotension-WHFS
Neisseria Meningitidis

Endotoxin causes vascular necrosis.
Dx:
Growth on Thayer-Martin VCN

Chocolate Augar
Vancomycin (+)
Colistin (-)
Nystatin (Fungus)
Neisseria Meningitidis + Neisseria Gonorrhoeae

Differentiate via metabolism
glucose vs maltose fermentation
Clinical presentation of Meningitis in:

Infant:
Older infant:
Infant:bulging open anterior fontanel

Older infant: Stiff neck, + Kernig's/Brudzinski signs
Intravascular invasion causes fever and petichial rash.

Dissemination = meningitis or fulmanint WFS (hypotension + tachycardia)
Meningococcemia = Petichia + Meningitis + WFS
Dx: via blood, Petichiae or CSF
Neisseria Meningitidis

Grow on Thayer-Martin VCN
Neisseria Meningitidis virulence factors
Capsule - ABCDXYZW135 Antigens
Meningitis caused by ABC

Endotoxin (LPS)- causes bv hemorrhage
IgA1 Protease - cleaves IgA
Neisseria Gonorrhoeae virulence factors
Pili - constantly changing
Protein II - Adherence factor
Men = urethritis (pain + pus)
Women = PID, Fitz Hugh Curtis
both = Septic Arthritis
Neonates = conjunctivits
Neisseria Gonorrhoeae

Invades and hides within WBC's on biopsy. Look for Diplococci inside WBC's
Part of the normal respiratory flora

Kids - Otitis media
Respiratory infections
Branhamella Catarrhalis/
Neisseria Catarrhalis

Beta lactam Resistant

Tx:Azithromycin/Clarthiromyciin
amoxicillin with clavulante
2/3rd Cephalosporin
TMP-SMX