Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
The most severe form of this disease results from the inhalation of spores with mediastinitus, pulmonary edema and hemorrhage (Woolsorter's Disease)
|
Bacillus Anthracis - Aerobic
Infection via endospores, soil or animal products Herbivores (cows,sheep)textiles Cutaneous, Pulmonary, GI pXO1 plasmid =3 Exotoxins EF - increases cAMP, edema PA - promotes EF entry LF - macs release TNF alpha, IL1 pXO2 plasmid = poly glutamyl capsule (protein capsule) Tx: Penn, erythromycin, doxyclyclin, ciprofloxacin, levofloxacin Prophylaxis: Vaccine of PA |
|
|
Causes gastroenteritis and is typically associated with the consumption of reheated rice.
|
Bacillus Cereus - Aerobic
Motile, non-encapsulated, penn resistant Enterotoxins - increase cAMP Heat labile - similar to E.coli Heat Stable - similar to S.aureus H+ Flagella Tx: Vancomycin, clindimycin Beta lactam resistant B. serious, no antibiotics for enterotoxins! |
|
|
Associated with the use of broad spectrum antibiotics and the overgrowth of toxin producing bacteria
Ampicillin/Amoxycillin, clindamycin, cephalosporins |
Clostridium Difficile - Anaerobic
Pseudomembranous Enterocolitis Exotoxins A - Diarrhea B - Cytotoxic Dx: toxins in the stool Tx: Metronidazole, Vancomycin |
|
|
Can cause risus sardonicus, the characteristic grimace of lockjaw (trismus). Infection is associated with traumatic inoculation of spores that germinate and produce a toxin that causes a spastic paralysis.
|
Clostridium Tetani - Anaerobic
Tennis racket spore Exotoxin: Tetanospasmin, prevents Renshaw cell interneurons from releasing GABA and glycine = SPASTIC PARALYSIS Tx: antitoxin + antispasmodics like benzodiazepines Prophylaxis: Vaccine DPT. Admin at 2,4,6,18 months + every 10 yrs Pt Types: >10yrs = give booster Never had vaccine = give booster + ab to tetnus toxin Tetnus = give ab, clean, penn, supportive therapy |
|
|
Disease can be due to the ingestion of preformed toxin in home canned foods or by the ingestion of spores in honey by an infant
|
Clostridium Botulinum - Anaerobic
Neurotoxin blocks Ach release (xs sympathetic response) Adult: FLACCID PARALYSIS, Respiratory failure, diplopia, dyphagia Cranial nerve palsy, mm weakness Tx: Antitoxin, Penicillin, Hyperbaric O2, Supportive Ventillation, intubation Infant: Constipation, floppy baby Tx: supportive therapy |
|
|
The only bacteria with a capsule composed of protein
|
Bacillus anthracis
pOX2 plasmid - poly glutamyl capsule |
|
|
Cutaneous infection results in a painless round black lesion with an edematous rim. (malignant pustule)
|
Bacillus anthracis
Lesion caused by exotoxin pXO1 plasmid =3 Exotoxins EF - increases cAMP, edema PA - promotes EF entry LF - macs release TNF alpha, IL1 |
|
|
Woolsorter's Disease
|
Pulmonary Bacillus anthracis infection causes mediastinal widening due to mediastinal hemorrhage and pleural effusions from macrophage migration to lymph node.
|
|
|
Necrotic lesion on intestine causing bloody diarrhea, vomiting and abdominal pain
|
GI Bacillus anthracis infection due to exotoxin release.
pXO1 plasmid =3 Exotoxins EF - increases cAMP, edema PA - promotes EF entry LF - macs release TNF alpha, IL1 |
|
|
Causes gas gangrene and is often associated with automobile and motorcycle accidents
|
Clostridium Perfringens - anaerobic
Lecithinase Cellulitis - crepitus Clostridial Myonecrosis - mm life threatening, black fluid Tx: debridement, pennicillin, hyperbaric O2 |
