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13 Cards in this Set
- Front
- Back
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HPV (does or doesn't) have an envelope?
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no envelope, makes it resistant to death= more likely to cause infection
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How is HPV spread?
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contact with broken skin
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Aspiration of HPV can occur during childbirth to cause ...
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respiratory papillomatosis in the newborn
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WHich HPV is considered high risk for cervical cancer?
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16, also 18
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HPV viral DNA is maintained in a ring form by which viral protein?
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E1 (a helicase)
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HPV establish infection in which layer of epithelium?
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basal layer
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Fact: HPV is not a lytic virus
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the virus does not cause any immediate epithelial damage
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HPV can remain infectious for long periods of time due to ...
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protein capsid
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Formation of the HPV capsid mediated by which HPV proteins?
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L1 and L2
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3 major ways HPV leads to neoplasm
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loss of RB (via E7), loss of p53 (via E6), telomerase (via E6)
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Ubiquitination of p53 does what?
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signals it for degradation, this is bad. HPV protein E6 does this to lead to cervical cancer
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What does HPV E7 do to RB?
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binds to RB and releases EF2 transcription factor to lead to unregulated transcription
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How does imiquimod work to help HPV?
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stimulate immune response
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