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28 Cards in this Set
- Front
- Back
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What is the scientific name of Carrions disease?
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Bartonellosis
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Where is bartonellosis found?
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South America
Peru Columbia Equador |
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At what degres is bartonellosis found?
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Between 5 degrees North and 15 degrees south
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At what alltitude is bartonellosis found?
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Between 500-3400 m above sea level (the Andes)
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Which city in Peru has highest amount of cases?
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Cajamarca
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Overall is this a common or rare disease?
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Rare disease overall that affects travelors and non-residents
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What are the two stages in bartonellosis?
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Oroya Fever - acute
Verruga Peruana - chronic |
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Why is bartonellosis disease important?
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-present in a area where there are a lot of tourists
-case fatility rate is 40-90% if untreated |
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What outbreak happened in the mid 1800s?
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Oroya railroad was being build
7000 deaths |
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Who was the med student who inoculated himself?
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Daniel Alcides Carrion
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What did Daniele Alcides Carrion inoculate himself with?
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Verrgua lesion
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Who identified Bartonella bacilliformis within erythrocytes?
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Alberto Barton
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When did Alberto Barton identify bartonella bacilliformis within erythrocytes?
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1905
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Are Bartonella spp. closely or distanly related?
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Closely
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What did clay sculptures from the pre-Columbian time portray?
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warts
verruga peruana peruvian warts |
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What is the life cycle of bartonellosis?
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Human is bite by sand fly (Lutzomyia verrucarum)
Human either dies or develops to acute stage: Oroya fever This progresses to chronic stage: verrgua peruana Bartonella bacilliformis develops in blood Transmitted to sand fly when bitten by fly |
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Which countries is bartonellosis present?
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Peru
Columbia Equador |
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What are the four stages of bartonellosis?
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1. Incubation: 3w (2-14w)
endothelial cells, RES 2. Oroya Fever: 2-4w erythrocytes, fever, anemia 3. Intercalar period: 2 m asymptomatic, skin 4. Verrgua peruana: months - 1 year red cutaneous nodule, peruvian wart |
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What is the most important infectious complication with bartonellosis?
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Salmonellosis
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What are three types of lesions that may appear with bartonellosis?
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Miliary, nodular, mular
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What three things are possible when you biopsy papules?
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Rocha lima inclusions
Vascular tumor like proliferation silver stain |
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What age group has the highest incidence to bartonellosis?
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0-4 year old
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How do you diagnose bartonellosis?
What are the three best ways? |
epidemiology
clinical picture **blood smear (Giemsa, bacteria in erythrocytes) **serologic tests PCR: not commercially used histology: biopsy **culture |
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What is the vector that transmits bartonellosis?
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Sand fly: Lutzomyia verrucarum
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Which medications are used for the acute phase of bartonellosis?
What qualifies as acute phase? |
**Cephalosporins
chloramphenicol cipro PCN streptomycin 7-10 days |
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Which medications are used to treat the chronic phase of bartonellosis?
What qualifies as acute phase? |
Quinolines
rifampin azithromycin streptomycin surgery 10-14days |
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What is the best way to prevent bartonellosis?
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Avoid contacts with vectors
- stay indoors at high risk hours -repellants -bed netting |
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What is a differential diagnosis for bartonellosis?
Why is this a differential diagnosis? |
Malaria
fever anemia presents in erythrocytes **Geographic area |
