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7 Cards in this Set

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How does mycobacteria resist cell-mediated immunity?
By inhibiting phagolysosomal fusion
How does herpes simplex resist cell-mediated immunity?
By interfering with the TAP transporter which presents antigen presentation on MHCI
How does CMV resist cell-mediated immunity?
(two ways)
1. Inhibits proteasomal activity
2. Removes class I MHC from ER
How does EBV resist cell-mediated immunity?
(two ways)
1. Inhibits proteasomal activity
2. Produces IL-10 which inhibits macrophage activation! (TH2-ish)
How does the pox virus resist cell-mediated immunity?
By producing soluble cytokine receptors that blunt the cell-mediated immune response.
What causes the symptoms of toxic shock syndrome?
Massive and unregulated cytokine production
What triggers the cytokine production in TSS?
Superantigen which triggers Tcells nonspecifically.