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16 Cards in this Set
- Front
- Back
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Strep agalactiae
Characteristics |
1) Group B step, Beta hemolytic
2) Virulence: Capsular polysaccharide, hyaluronidase, collagenase, 3) Leading cause of neonatal meningitis 4) Most transmitted during delivery |
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Strep agalactiae
Early onset disease |
1) Maternal obstetric complication occur
2) Symptoms develop in first 5 days 3) Clinical: bacteremia, pneumonia, meningitis |
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Strep agalactiae
Late onset disease |
1) No maternal obstetric complications
2) Symptoms develop 7days to 3 months 3) Clinical: bone/joint infections, bacteremia, cancomitant/fulminant meningitis |
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Strep agalactiae
Diagnosis |
1) Antigen detection( polysaccharide)
2) DNA probe 3) Culture bacteria from blood, CSF or site of suppuration--> diagnositic |
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E. coli Meningitis
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1) G- Bacillus encapsulated K1 strain
2) Neonate infected from vaginal colonization form mother's rectum |
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Seasonality and Incidence
H. Flu B |
Late winter/ early spring
Infants 7- 18 months |
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Seasonality and Incidence
N. Meningitidis |
Winter
Infant/children (1month-19 yo) |
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Seasonality and Incidence
S. Pneumonia |
Winter
Infants/children (1 mo>4 yo) Adults-esp. elderly |
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Seasonality and Incidence
S. agalactiae |
Winter
Neonates( < 1 mo)/ Adults |
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Seasonality and Incidence
L. Monocytogenes |
Summer
newborns/predisposed adults |
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Listeria monocytogenes
Morpology |
G+ motile coccobacillus
requires reduced 02 for growth Facultative intracellular- Monocytes and macrophages and epithelial cells |
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Listeria monocytogenes
Virulence factors |
1) Lipopolysaccharide-like surface component- antiphagocitic-induction of C hemolytic antibodies
2) Listeriosin O- disrupts phagolysosome membrane- inhibits antigen processing. |
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Listeria monocytogenes
Pathogenesis |
1) Two manifestations: sepsis, meningitis
2) Ingested on raw or under cooked food 3) Enters though epithelial cells: either destroyed or infects machrophages and parenchymal cells |
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Listeria monocytogenes
Clinical Neonatal |
1) Acquired in utero: stillbirth, abortion or pneumonia, seizures, skin lesions.
2) High mortality if not diagnosed early 3) Aquired from mother's genital tract results in meningitis |
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Listeria monocytogenes
Clinical Adult |
1) Leading cause of meningitis in renal transplant and cancer
2) Brain stem inflammation is classic |
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Listeria monocytogenes
Diagnosis |
1) Alert laboratory of suspicion
organisms are very pleomorphic 2) Culture of bacilli is diagnostic, 3) Must homogenize tissue to release Tumbling motility of Bacilli 4)DNA probe is available |
