Micro The Rest Of The Dna Viruses

Front 1

Who belongs with the DNA viruses?

Back 1

HHAPPPy: Herpesviridae, Hepadenaviridae, Adenoviridae Poxviridae, Papovvaviridae, and Parvoviridae.

No "Y"

Front 2

What is the morpology of poxviridae?

Back 2

ds linear DNA, complex nucelocapsid, enveloped.

Front 3

Unlike other DNA viruses, where does the Poxviridae replicate?

Back 3

In the cytoplasm.

Front 4

What causes smallpox?

What is its morphology?

Back 4

The variola virus--Poxviridae orthopoxvirus.

ds linear DNA, complex nucleocapsid envelop.

Note: on EM, it has a dumbbell-shaped core and complex mm system.

Front 5

What is the difference between smallpox and chickenpox in terms of lesions?

Back 5

Smallpox: synchronous lesions, deep lesions, centrifugal spread, prominent face and palms.

Chickenpox: asynchronous lesions, superficial lesions, centripetal spread, prominent in chest (does not usually involve the palms and soles).

They both look like a "dew on a rose petal"

Front 6

What can cause Molluscum contagiosum? What is it?

Back 6

Poxviridae (not the variola, smallpox strain).

Small white bumps with a central dimple (like a wart). Often found in the genital region.

Front 7

What virus has been successfully eliminated? How is it spread? How long is a person contagious with this disease? What is the treatment for this disease other than vaccine for prevention?

Back 7

Poxviridae orthopoxvirus--smallpox virus (variola).

Respiratory droplets.

Sometimes before the onset of a fever (prodrome phase) until the last smallpox scab falls off.

There is no treatment; only supportive care.

Front 8

How was the vaccine for smallpox utilize? What is considered to be a successful vaccination?

Back 8

From an unrelated avirulent pox virus, called vaccinia that was able to induce immunity to the smallpox virus.

Painful pustule develops (the "Jennerian vesicle") indicating that the virus has multiplied in the recipient and elicited an inflammatory response.

Front 9

The presumptive bioterrorism-related smallpox outbreak, the key responsibility for a laboratory is to?

Back 9

Rule out chickenpox and obtain instructions for properly collecting vesicular fluid.

The testing should be conducted in a CDC Laboratory Response Network (LRN) using LRN-approved PRCR tests and protocols.

Consultation with state or local health authorities should be involved, infectious disease clinicians, immunology experts, and the CDC.

Front 10

What is the major concern over Poxviridae orthopoxvirus?

Back 10

It can be used for bioterrorism.

Front 11

In terms of the vesicle, what is a defining characteristic of smallpox lesion?

Back 11

THe variola virus will produce a rash that develops into raised bumps with with thick, opaque fluid; however, it will often have a depression that is a distinguishing feature of smallpox.

Front 12

Most DNA viruses are ds, show icosahedral symmetry, and replicate in the nucleus, except for?

Back 12

Parvoviridae: ssDNA

Poxviridae: DNA is surrounded by complex structural proteins looking much like a BOX--"COMPLEX NUCELOCAPSID." DNA also replicates in the cytoplasm.

Front 13

Adenovirus is transmitted by?

Back 13

By direct contact, fecal-oral transmission, and occasionally waterborne transmission.

Note: Adenovirus may attach or embed in suspended particles in turbid water, and these virus-containing particles precipitate into the sediment on the bottom of the pool, where they may remain viable and remerge when swimmers agitate the pool.

Front 14

What can adenovirus cause?

Back 14

Upper respiratory infection: rhinitis, sore throat, which may progress to atypical pneumonia.

Conjunctivitis, with red eye.

Can cause hemorrhagic cystitis.

Can also cause fever with watery diarrhea (usually in day care settings).

Acute respiratory distress syndrome (ARDS): fever, rhinorrhea, cough, and sore throat.

Front 15

Adenovirus is transmitted by?

Back 15

By direct contact, fecal-oral transmission, and occasionally waterborne transmission.

Note: Adenovirus may attach or embed in suspended particles in turbid water, and these virus-containing particles precipitate into the sediment on the bottom of the pool, where they may remain viable and remerge when swimmers agitate the pool.

Front 16

What can adenovirus cause?

Back 16

Upper respiratory infection: rhinitis, sore throat, which may progress to atypical pneumonia.

Conjunctivitis, with red eye.

Can cause hemorrhagic cystitis.

Can also cause fever with watery diarrhea (usually in day care settings).

Acute respiratory distress syndrome (ARDS): fever, rhinorrhea, cough, and sore throat.

Front 17

What are the viral respiratory illness in children in order of frequency?

Back 17

RSV, parainfluenza, rhinovirus, adenoviridae

Front 18

Adenovirus has tropism for?

Back 18

Mucosal epithelium of upper respiratory tract, conjunctivae and other areas.

Front 19

Adenovirus gains entry into the target cells via?

Back 19

Attachment to receptors on the cell surface using their fiber protein.

Front 20

Cell-mediated immunity against adenovirus contributes to?

Back 20

Fever, sore throat, corynza, red eyes, lasting around 5 days.