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70 Cards in this Set

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Virus structure
DNA (linear or circular) or RNA surrounded by a protein coat
Most viral genomes contain ___ genes
few. Genomes are small (200-300 proteins). a few thousand base pairs
Capsid
Protective coat around nucleic acid
Nucleocapsid
nucleic acid and the capsid
Outer envelope of virus
sometimes has glycoprotein spikes
Influenza viruses have spikes that do what
Hemeagglutination (RBC to cluster) and Neuraminidase (penetration of virus through mucus in Respiratory tract)
What basic shapes do virusus use?
polyhedral, helical, and binal
Plant viruses
Many are RNA. Don't penetrate (rely on existing damage). transmitted by insects
Tobamovirus
tobacco mosaic virus
Animal viruses
divided into DNA and RNA
Animal DNA viruses replicate ____
nucleus or cytoplasm
Poxvirus
small pox
Parvoviridae
smallest viruses of vertebrates. linear ssDNA. ex. Minute virus of Mice (MVM)
Papillomavirus
remains dormant in tissue and integrates into genome. Genital warts. over 60 types of HPV. 58% of cervical cancers
Polyomovirus
oncogenic virus - Monkey Kidney cells
Herpesviridae
Herpes simplex 1 and 2. cytomeglovirus. Epstein Barr. Varicella-Zoster. Herpes 6,7,8
Cytomegelovirus
congenital infections. mother to fetus. organ transplant. immunocompromised. spread by fluid. maybe lifelong
Epstein-Barr virus
mononucleosis - fever, malaise, pharyngistis and lymphadenopathy
Varicella-Zoster virus
chicken pox. remains latent in spinal cord. can become shingles
Herpesvirus 6, 7, 8
6 lymphoproliferative. 7 skin rash and chronic fatigue syndrome. 8 Karposi's sarcome.
Picornaviridae
coxsackievirus - myocarditis. poliovirus (Salk vaccine)
Orthomyxoviridae
influenza A, B, and C
Rhabdoviridae
rabies
Lab cultivation of viruses
done in special flask. special amino acids, vitamins, ions, buffers, and animal serum. Incubator with 5% CO2.
assay of viruses
count with electron microscope on grid. doesn't distinguish live from dead.
Hemagglutination assay
virus that have hemegglutionatin spikes. assayed with RBC;s. they bridge and form clumps
Replication of viruses (5 steps)
1. Attachment to Host. 2. penetration. 3. replication and synthesis of viral proteins. 4. assembly and maturation of new virus particles. 5. Release virus (steps 1-3 are eclipse phase)
Inducing agents for lysogeny
UV light and mitomycin C
Strains that have lysogenic conversion
C. diphtheriae, S. pyogenes and C. botulinum
viroids
consist only of nucleic acid. protected bc tightly folded
prions
proteinaceous infectious particles. neurological disease in sheep, goat, and deer
Kuru
prion illness seen in cannibals
Bovine spongiform encephalopathy
mad cow disease. caused by prions
Interferon
interferes with viral replication - specifically mRNA
Acylovir
drug given to people with genital herpes - nucleoside derivative
Virus structure
DNA (linear or circular) or RNA surrounded by a protein coat
Most viral genomes contain ___ genes
few. Genomes are small (200-300 proteins). a few thousand base pairs
Capsid
Protective coat around nucleic acid
Nucleocapsid
nucleic acid and the capsid
Outer envelope of virus
sometimes has glycoprotein spikes
Influenza viruses have spikes that do what
Hemeagglutination (RBC to cluster) and Neuraminidase (penetration of virus through mucus in Respiratory tract)
What basic shapes do virusus use?
polyhedral, helical, and binal
Plant viruses
Many are RNA. Don't penetrate (rely on existing damage). transmitted by insects
Tobamovirus
tobacco mosaic virus
Animal viruses
divided into DNA and RNA
Animal DNA viruses replicate ____
nucleus or cytoplasm
Poxvirus
small pox
Parvoviridae
smallest viruses of vertebrates. linear ssDNA. ex. Minute virus of Mice (MVM)
Papillomavirus
remains dormant in tissue and integrates into genome. Genital warts. over 60 types of HPV. 58% of cervical cancers
Polyomovirus
oncogenic virus - Monkey Kidney cells
Herpesviridae
Herpes simplex 1 and 2. cytomeglovirus. Epstein Barr. Varicella-Zoster. Herpes 6,7,8
Cytomegelovirus
congenital infections. mother to fetus. organ transplant. immunocompromised. spread by fluid. maybe lifelong
Epstein-Barr virus
mononucleosis - fever, malaise, pharyngistis and lymphadenopathy
Varicella-Zoster virus
chicken pox. remains latent in spinal cord. can become shingles
Herpesvirus 6, 7, 8
6 lymphoproliferative. 7 skin rash and chronic fatigue syndrome. 8 Karposi's sarcome.
Picornaviridae
coxsackievirus - myocarditis. poliovirus (Salk vaccine)
Orthomyxoviridae
influenza A, B, and C
Rhabdoviridae
rabies
Lab cultivation of viruses
done in special flask. special amino acids, vitamins, ions, buffers, and animal serum. Incubator with 5% CO2.
assay of viruses
count with electron microscope on grid. doesn't distinguish live from dead.
Hemagglutination assay
virus that have hemegglutionatin spikes. assayed with RBC;s. they bridge and form clumps
Replication of viruses (5 steps)
1. Attachment to Host. 2. penetration. 3. replication and synthesis of viral proteins. 4. assembly and maturation of new virus particles. 5. Release virus (steps 1-3 are eclipse phase)
Inducing agents for lysogeny
UV light and mitomycin C
Strains that have lysogenic conversion
C. diphtheriae, S. pyogenes and C. botulinum
viroids
consist only of nucleic acid. protected bc tightly folded
prions
proteinaceous infectious particles. neurological disease in sheep, goat, and deer
Kuru
prion illness seen in cannibals
Bovine spongiform encephalopathy
mad cow disease. caused by prions
Interferon
interferes with viral replication - specifically mRNA
Acylovir
drug given to people with genital herpes - nucleoside derivative