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11 Cards in this Set
- Front
- Back
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Definition of Tolerance
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Unresponsiveness INDUCED by previous exposure
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What is Anergy? What causes it?
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Unresponsiveness of cells due to a lack of 2nd signal?
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What is AIRE, & it's function?
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Encodes TF's for many precursor proteins, to delete self-reactive T-cell
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What do T-Regs do? Where to they function?
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They are Regulatory T-cells, expressing CD4, CD25, FoxPR, TGF-beta and IL-10 to inhibit other T-cells
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What is IPEX syndrome? What is it caused by?
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Fatal autoimmune disease caused by mutation in Foxp3
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Give 3 examples of Autoimmune disease
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Type 1 diabetes, Myasthenia Gravis and Sjorgren's syndrome
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What is Type 1 diabetes?
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Autoimmune disease where T-cells attack beta cells from islets of langerhans = LACK OF INSULIN
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What is Mysathenia Gravis
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Ab's mess with AcH receptors @ neuro-musc junction = NO CONTRACTION
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What is Sjorgren's syndrome
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Autoimmune disease Ab's/T cells destroy glands of tears/saliva
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Give 5 ways that Tumors escape the immune response
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1. Don't express Ag/Co-stim molecules
2. Low levels of MHC class 1/2 3. Ag level is TOO LOW or TOO HIGH @ beginning 4. secrete immunosupressive molecules 5. Induce t-reg cells |
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What are the 3 vaccine practices today?
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1. Killed- normal infectious virus, that is rendered non-pathogenic
2. Attenuated - live virus particles but don't cause disease because of mutation to a non-path form 3. Subunit - purified COMPONENTS like surface Ag of a virus |
