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20 Cards in this Set
- Front
- Back
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What part of a B-cell allows them to recognize an Antigen?
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A BCR
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What is a BCR? (location, other name)
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Cell-surface bound Ig (antibody)
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How do the following compounds relate to B-cell activation?
C3d CR2 CD19/CD81 |
C3d - binds to microbes,
CR2 - recognizes the C3d CD19/81 - assist in ingestion/activation |
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What 2 classes of Immunoglobulins does a Mature, naive B-cell express?
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IgM and IgD
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Where are Antibodies produced?
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in the secondary lymph tissue
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Within a lymph node, where are B cells? where are t cells? where do they interact?
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B-cells in follicle, T-cells in pericorticol zone, interact @ junction of the 2
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Describe the B-T cell interaction from B-cell perspective, starting w/ recognition of Ag.
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1. recognize Ag
2. receptor-mediated endocytosis 3. Process, present Ag via Class 2 MHC 4. CD4 cell recognize Ag |
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What enzyme causes mutaitons to allow for Ab dicersity?
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Activation-Induced Deaminase
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What are the 3 types of B cells?
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B1, and B2 - (follicular and Marginal zone)
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What type of B-cells are T-dependent, what are non?
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Follicular B cells are T- dependent
B1 cells and Marginal zone are T-independent |
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Which cytokines result in which isotype switches for B-cells?
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IFN-y - IgG
IL4 - IgE Mucosal (TGF, BAFF) - IgA |
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What are the VARIABILITY SITES of Ig Molecules?
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CDR 1,2 3
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Which IGs are involved in the Primary immune response?
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IgM and IgG
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What Ig's are invovled in the secondary response?
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IgA and IgE and MORE IgG
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What are the cytokines released by Th1 cells as it relates to Bcells?
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IFN-y, causes activation of complement binding/opso Ab pathways
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What are the cytokines released by Th2 cells as it relates to Bcells?
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IL4 - for IgG Abs and IgE Abs(mast cells)
IL5 for eosinophil activation (helminth) |
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What's ADCC?
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Antibody dependednt cellular toxicity, when an Ab binds to microbe and to NK cell.
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Which Ig matches each function?
1. Activate classical complement pathway 2. Mucousal immunity 3. Defense vs. Helminth 4. Neutralize microbes/toxins, opsonization, activate classical path, ADCC, neonatal, feedback inhibition |
1. IgM
2. IgA 3. IgE 4. IgG |
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How can IgA cross the mucosal epithelium into Lumen?
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a Dimeric IgA binds to the Ig-receptor
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What is the function of IgD?
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Ag receptor on naive cells
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