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22 Cards in this Set
- Front
- Back
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Where do T/B cells do their "effector" function? How do they get their?
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Site of infection, drawn by cytokines
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What is the SIGNAL 2 in T-cell/ APC interaction? How is it stopped?
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CD28 of T-cell binding to B7 of APC, stopped by CTLA-4 which binds B7
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What does the increase in Calcium (recruited by T/B cell receptors) increase the level of?
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Calcineurin, an enzyme which gives TF's, to make IL2
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What 3 things does Calcineurin require?
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NFAT
NF-kB Ap-1 |
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What are the 2 DOWNREGULATION path's of T-cells after binding APC?
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1. Eliminate Ag (death by neglect)
2. Persistance of Ag - Fas/Fas-L death receptors |
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How does B-cell signaling differ from T-cell?
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No IL2 in B-cell, doesn't require Signal 2
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What ENHANCES binding of B-cell to microbe? (involves C's)
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C3d binds microbe, B-cell CR2 binds C3d on microbe
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What are the 4 cytokines CD4 cells secrete?
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IFNy, IL4, TGFB, IL6
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What does IFNy do? What is it vital in response to?
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activates Macro, CD8 or B-cells, response to viruses
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Explain the interaction of Macrophage w/ IFNy (6 steps)
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1. Macrophage takes up pathogen
2. MHC reacts w/ TCR on t-cell 3. T-cell secretes IFN-gama 4. CD40L communitactes w/ CD40 of macrophage, 5. Macrophage activated 6. kills microbes |
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Where do T/B cells do their "effector" function? How do they get their?
|
Site of infection, drawn by cytokines
|
|
|
What is the SIGNAL 2 in T-cell/ APC interaction? How is it stopped?
|
CD28 of T-cell binding to B7 of APC, stopped by CTLA-4 which binds B7
|
|
|
What does the increase in Calcium (recruited by T/B cell receptors) increase the level of?
|
Calcineurin, an enzyme which gives TF's, to make IL2
|
|
|
What 3 things does Calcineurin require?
|
NFAT
NF-kB Ap-1 |
|
|
What are the 2 DOWNREGULATION path's of T-cells after binding APC?
|
1. Eliminate Ag (death by neglect)
2. Persistance of Ag - Fas/Fas-L death receptors |
|
|
How does B-cell signaling differ from T-cell?
|
No IL2 in B-cell, doesn't require Signal 2
|
|
|
What ENHANCES binding of B-cell to microbe? (involves C's)
|
C3d binds microbe, B-cell CR2 binds C3d on microbe
|
|
|
What are the 4 cytokines CD4 cells secrete?
|
IFNy, IL4, TGFB, IL6
|
|
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What does IFNy do? What is it vital in response to?
|
activates Macro, CD8 or B-cells, response to viruses
|
|
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Explain the interaction of Macrophage w/ IFNy (6 steps)
|
1. Macrophage takes up pathogen
2. MHC reacts w/ TCR on t-cell 3. T-cell secretes IFN-gama 4. CD40L communitactes w/ CD40 of macrophage, 5. Macrophage activated 6. kills microbes |
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Which Cd4 secreted cytokine is inolved in antibody production?
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IL4
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How many signals do CD8 cells require? What is it?
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JUST 1 - Ag and MHC - relaeases the Granzymes to enter the cell OR use FasL to interact w/ target cell's Fas to kill cell
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