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16 Cards in this Set
- Front
- Back
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Name the 5 cells (including the final one) in development of B/T cells
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1. Common Lymphoid progenitor
2. Pro B/T 3. Pre B/t 4. Immature B/T 5. mature B/T |
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What 3 enzymes are involved in B/T maturation?
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Rag 1, Rag 2, and Tdt - add nucleotides to sequences without a compliment strand
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When are CD3/4/8 present in T-cell maturation lineage?
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starting in immature T-cells
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When is CD19 present in B-cell maturatoin lineage? IgM?
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CD19 - proB cell
IgM - Imm B (low) high in mature |
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What are the 4 regions involved in Recombination of T/B cell Heavy Chain development?
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Variable, Diversity, Joining and Constant
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What is the order of assembly in recombination of Heavy Chain of B/T cell?
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D+J, add V then Add C, always starting w/ M
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What are the possible Constant areas of heavy/light chain B/T cell recombination?
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M, D, G,E, A
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How does the light chain differ from the heavy chain in terms of components for recombination?
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Light chain has no Diversity component,
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What is the order of assembly in recombination of light chain of b/t cell?
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a Vk, Jk, VL, JL, then add c
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How does the RAG enzyme know where to start when doing recombination?
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via a Recombination Signaling Sequence between Joining segments
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How are the Heavy and light chains assembled together?
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They are assembled into a linear structure, which folds over, and part is cut by exonuclease, and Ligase seals the ends together leaving a CODING JOINT and SIGNAL JOINT
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What Enzyme allows CLASS SWITCHING?
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AID - activation induced aminase
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Which is the best functionally characterized TCR?
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Alpha beta
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Which Ig's are present in the Primary Humoral response? The secondary?
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IgM-primary, IgG - secondary
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Class 2 TCR are involved with what type of T-cells?
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CD4
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What is a Hapten?
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an Antigenic determinant that is immunogenic ONLY when fused to its carrier
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