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8 Cards in this Set
- Front
- Back
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Where is MHC? What does MHC do? What does it interact with?
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MHC is on a dendritic cell, it presents an Ag, interacts w/ TCR on t-cell
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Where is MHC-1 found? What does MHC1 present? What cells does it interact with?
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It is found on all cells, presents ENDOGENOUS Ag, to CD8 T cells
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Where is MHC2 found? What does MHC1 present? What cells does it interact with?
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on APC's, it presents Exogenous peptides to CD4 T cells
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What are 3 APCs?
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Dendritic cells, Macrophages, and B-cells
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What type of allelic expression do Human Leukocyte Antigens express?
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CODOMINANCE
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What is Signal 1 in MHC binding? What is Signal 2?
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signal 1 is binding of MHC to the TCR. signal 2 is T-cell activation
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What is Signal 2 in MHC.
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PRR binds Non self/slef that is DANGER SIGNAl amd release B7, which binds CD28/activates T-cell
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What is a SUPERANTIGEN?
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molecule that binds TCR and MHC and bind them non-specifically
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