Micro Stuff I Forget

Front 1

Test for Ricketsia

Back 1

Weil felix
Mix serum + proteus antigen. If serum has anti-ricketsia Ab, will agglutinate
Q fever (coxiella brunetti) is not positive for this

Front 2

Ricketsia

Back 2

R. Ricketsii- Rocky mountain spotted fever (ticks)
R. typhii-Endemic typhus (fleas)
R. Prowazeckii-Epidemic typhus-human body louse R.akari- Rickettsial pox
Erlichiosis- ticks from dog to dog
Coxiella burnetii- Q fever. queer because it has no vector (has spores) no rash, -ve weil felix
R. Ricketsii- rash starts on wRists
R. Typhus- Rash starts on Trunk

Front 3

obligate intracellular bugs

Back 3

chlamydiae- likes columnar epithelium- mucus membranes
Ricketsia- likes endothelial cells of blood vessels, causes vasculites- rash.

Front 4

test for cryptococcus

Back 4

LAtex agglutination, detects polysaccharide capsular antigen.

Front 5

Test for Candida

Back 5

Germ tube test-

Front 6

Naked Viruses

Back 6

RNA (CPR)
Calciviruses (HEV, Noro)
Picornaviruses (PERCH)
Reoviruses (Rota)

DNA (PAPP)
Parvo
Adeno
Papilloma
Polyoma

Front 7

Catalase -ve staph novobiocin test

Back 7

NO StRES

Saprophyticus resistant
Epidermidis sensitive

Front 8

Beta hemolytic strep bacitracin test

Back 8

B- BRAS
Strep B- resistant
Strep A-succeptible

Front 9

Growth media

Back 9

H.Flu-chocolate agar with hemantin (X) and NAD (V)
Legionella -Charcoal with iron and Cysteine
N Gonorrheae- Thayer martin (VCN)
B. Pertussis- Bordet Gengou (potato)
C. Diptheriae-Tellurite, loefflers media
M. Tb- lowenstein-jensen
Gram -ves (enterics) MacConkey's
Fungi-Sabouraud's

Front 10

live attentuated vaccines

Back 10

induce humoral and cell mediated immunity- can become virulent on occasion

MMR
Polio-Sabin
VZV
yelow fever
small pox
rotavirus
BCG
S.Typhi
Francisella Tularensis

Front 11

Killed

Back 11

induce humoral immunity only
Rabies,
influenza
Polio-salk
HAV
B. Anthracis
V. Cholerae
B. Pertussis
Y. Pestis

Front 12

Inactivated toxin (toxoid)

Back 12

C. Diptheriae
B. pertusis
C. Tetani

Front 13

Recombinant

Back 13

HBV (recombinant HBsAg)
B. Burdoferi (Recombinant bacterial outer surface

Front 14

Polysaccharide vaccines

Back 14

S. Pneumo (23 valent for at risk adults, 7 valent in kids < 2yrs)

N. Meningitidis (YWCA) 4 valent

H. flu

Front 15

why is MRSA resistant?

Back 15

Expresses an alternative penicillin binding protein/ transpeptidase that has a low affinity for beta lactams.

Front 16

penicillinase resistant penicillins

Back 16

methicillin, nafcillin and dicloxacillin (use for Staph aureus, except MRSA)

all other penicillins are penicillinase (B lactamase) succeptible! give with penicillinase inhibitors

Front 17

penicillinase (beta lactamase) inhibitors

Back 17

clavulanic acid
tazobactam
sulbactam

Front 18

Resistant to beta lactamases

Back 18

monobactams
carbepenems
Anti-staph (methicillin, nafcillin, dicloxacillin)

Front 19

Cilastin

Back 19

coupled to imipinem (carbapenem)
Lowersints inactivation in renal tubules

Front 20

Vanco (side eff)

Back 20

Nephrotoxic, Ototoxic, thrombophelbitis
Red man syndrome (give antihistamines prior)

Front 21

Aminoglycosides (side eff)

Back 21

NO (Nephrotoxic, ototoxic)
Neomycin- Myasthenia like sympt.
Need O2 to work wont work with anerobes

Front 22

Tetracycline (side eff)

Back 22

Doxy- fecal elimination, dont give antacids. divalent ions lower absorption
Demeclocycline- ADH antagonist (use in SIADH)
*discolor teeth, inhibit bone growth.

Front 23

Macrolides

Back 23

erythromycin, azithromycin, clarithromycin
Block pore of escape from ribosome.
use in atypical pneumonias
Erythro- Guillan barre like symptoms. P450 inhibit
*cholestasis, eosinophilia

Front 24

Clindamycin

Back 24

anerobes
causes C. diff

Front 25

cephalosporins

Back 25

disulfiram like effects with alcohol
Metronidazole has this effect too.

Front 26

Flouroquinolones

Back 26

dont take with antacids- divalent ions lower abs.
GI upset, tendoitis, damage to catrilage in kids

Front 27

polymixins

Back 27

mix up membranes (act like detergents)

Front 28

TB treatment

Back 28

INH/RIF/ ETH/PYR- 2mths
INH/RIF 4mths
INH/RIF 3 mths (if cavity, +ve culture)

*INH- hepatotoxic, neurotoxic (antagonize B6- sythesis of GABA)
RIF- orange body fluids

Front 29

prophylaxis

Back 29

INH ---- TB
RIF-- meningococcus, hemophilus type B in kids,
Azithromycin- MAI (acid fast, +hepatosplenomegaly)
ceftriaxone-gonorrhea
Penicillin G- syphillis
TMP/ SX, pentamidine- Jirovecci

Front 30

ethambutol

Back 30

inhibits arabinosyl transferase (component of cell walls)
*red color blindness

Front 31

Antifingals that make holes on ergosterol on membrane

Back 31

Amphotericin B, nystatin
Amphotericin- fever, chills, nephrotoxic
Nystatin-use for oral candida, and topically

Front 32

Azoles

Back 32

inhibit ergosterol (fungal steroid) synthesis
fluconazole -cross BBB

Front 33

flucytosine

Back 33

made into lfourouracil, prevent DNA formation- ruins bone marrow

Front 34

caspofungin

Back 34

inhibits cell wall synthesis
Invasive aspergillus

Front 35

terbinafine

Back 35

inhibits squelene epoxidase
use for dermatophytes

Front 36

Griseofulvin

Back 36

messes with microtubules
*dermatophytes
*p450

Front 37

Amantadine

Back 37

uncoating, influeza A
Parkinsons!!

Front 38

ribavirin mechanism

Back 38

competitively inhibit IMP dehydrogenase- inhibits sythesis of guanine nucleotides
*aerosol RSV in kids

Front 39

bacteriostatic

Back 39

We're ECSTaTiC about bacteriostatics!!
Erythromycin
Clindamycin
Sulfamethoxazole
Trimethoprim
Tetracycline
Chloramphenicol

Front 40

Bactericidal

Back 40

Very Finely Proficient At Cell Murder

Vanco
Flouroquinolones
Penicillin
Aminoglycoside
Cephalosporins
Metronidazole