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11 Cards in this Set
- Front
- Back
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What are rickettsial diseases?
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Arthropod borne (except Coxiella burnetti)
gram negative rods Small, obligate intracellular organism Named after Dr. Ricketts |
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Where can you grow rickettsia in a lab?
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Difficult -- don't grow on artificial media
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How do you stain rickettsia?
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Geimsa stain (cuz intracellular)
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What are the 5 grous of rickettsial diseases?
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Typhus (epidemic and endemic)
Spotted fevers (RMSF, Rickettsialpox, tick typhus) Scrub Typhus Trench fever Q-fever (the oddball) |
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What is the pathological lesion of rickettsia?
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Vasculitis, often with an eschar at the site of insect bite/attachment
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What are the common clinical findings of Rickettsial dz?
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Rash (not Q fever)
Fever Headache Conjunctivitis Pharyngitis Eschar (Scrub and Spotted) Myalgias Arthralgias HSM |
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What common ricketsial sx does q-fever not have?
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No rash
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What are the most useful diagnostic tests for q-fever?
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Serology
Anti-rickettsial titres (CF, IFA, EIA) High IgM Titre with four fold rise in paired sera Weil Felix test |
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What is the Weil Felix test
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Test for Rickettsial dz
Mix serum with salmonella antigen (per oberhelman) (Antibodies that cross react with Proteus ox19, ox2, oxK) Cross reaction/clumping a positive test "febrile agglutination test" |
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Is culturing rickettsia a good idea?
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It's difficult and HAZARDOUS
(hey, let's do it in microlab without gloves and a mask!) |
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What is Epidemic Louse Borne Typhus?
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Epidemic because strictly human disease
Rockettsia prowazekii |
