Micro Q1

Front 1

PABA analog

Back 1

Sulfonamide

Front 2

Bactrim

Back 2

Combination of trimethoprim and sulfamethoxazole

Front 3

These two penicillins are resistant to penicillinase.

Back 3

Methicillin, oxacillin

Front 4

Broad spectrum antibiotics include...

Back 4

Ampicillin and amoxicillin, cephalosporins, imipenem (a carbapenem), tetracyclines, chloramphenicol, erythromycin

Front 5

Narrow spectrum antibiotics include...

Back 5

Vancomycin

Front 6

These two penicillins have a broad spectrum of action

Back 6

Ampicillin, amoxicillin

Front 7

Components of fungal cell walls

Back 7

Chitin (acetyl glucosamine polymer), glucan

Front 8

Components of bacterial cell walls

Back 8

Peptidoglycan polymers

Front 9

Component of fungal cell membrane

Back 9

Ergostol

Front 10

These are commonly used to treat UTIs

Back 10

Sulfonamides

Front 11

This drug inhibits dihydrofolate reductase

Back 11

Trimethoprim

Front 12

This drug inhibits synthesis of mycolic acid

Back 12

Isoniazid

Front 13

These drugs are used to treat TB

Back 13

Isoniazid (-cidal), ethambutol (-static), pyrazinamide (-cidal)

Front 14

All members of these classes of drugs are bactericidal

Back 14

Cell wall synthesis inhibitors, drugs that affect cell membrane permeability

Front 15

Relies on autolysins to kill bacteria

Back 15

Penicillins and other cell wall inhibitors

Front 16

This penicillin is deactivated by acid

Back 16

Penicillin G

Front 17

These drugs function by inhibiting transpeptidases

Back 17

Penicillins

Front 18

This penicillin has no oral formulation

Back 18

Penicillin G

Front 19

This penicillin is relatively acid stable

Back 19

Penicillin V

Front 20

This is a carboxypenicillin

Back 20

Ticarcillin

Front 21

This is a ureidopenicillin, and is most active against G- enteric bacilli

Back 21

Piperacillin

Front 22

This drug is avoided in adults because of high incidence of interstitial nephritis

Back 22

Methicillin

Front 23

This drug is indicated for pts with penicillin allergies

Back 23

Cephalosporins

Front 24

This family of drugs is able to enter CSF

Back 24

Cephalosporins

Front 25

These drugs have greater acid stability and resistance to penicillinase

Back 25

Cephalosporins

Front 26

This drug has the broadest antimicrobial spectrum

Back 26

Imipenem (a carbapenem)

Front 27

This drug is susceptible to breakdown by renal dipeptidase

Back 27

Impenem

Front 28

These are beta-lactamase inhibitors and are used in conjunction with penicillins to increase efficacy

Back 28

Clavulanic acid, sulbactam

Front 29

This drug belongs to the glycopeptide class of cell wall inhibitors and has a very narrow spectrum

Back 29

Vancomycin

Front 30

This drug is ototoxic and nephrotoxic

Back 30

Vancomycin

Front 31

This drug is a D-ala analog

Back 31

Cycloserine

Front 32

This drug inactivates the phosphatases responsible for generating the active form of the carrier lipid in murein (peptidoglycan) precursor synthesis

Back 32

Bacitracin

Front 33

The positively charged polypeptide antibiotic binds to the (-) charged LPS, causing membrane leakage

Back 33

Polymyxin B

Front 34

These are aminoglycosides

Back 34

Streptomycin, gentamicin

Front 35

These bind to the 30S subunit of bacterial ribosomes

Back 35

Aminoglycosides, tetracyclines

Front 36

Does not penetrate bacteria readily, and some metabolic activity by the bacterium is needed for it to enter

Back 36

Streptomycin

Front 37

Its action is inhibited under anaerobic or acidic conditions, such as in urine

Back 37

Streptomycin

Front 38

Bacteria CANNOT obtain resistance in "one step" because they interact with more than one ribosomal protein on the 30S subunit

Back 38

Gentamicin

Front 39

Bacteria CAN obtain resistance in "one step" because they interact with only one ribosomal protein on the 30S subunit

Back 39

Streptomycin

Front 40

Ototoxic and nephrotoxic

Back 40

Aminoglycosides

Front 41

These are well absorbed orally and suited to outpatient treatment when therapy is needed over a week or two

Back 41

Tetracyclines

Front 42

These drugs can cause mottled enamel in children under the age of 8

Back 42

Tetracyclines

Front 43

This is a new drug that evades efflux pumps in bacteria that are resistant to other members of its class

Back 43

Tigecycline

Front 44

Prolonged oral administration can change the composition of GI flora

Back 44

Tetracyclines and other broad spectrum drugs

Front 45

These inhibit 50S function

Back 45

Erythromycin, azithromycin, chloramphenicol, clindamycin

Front 46

First new class of anti-ribosomal drugs developed in 35 years

Back 46

Oxazolidinones (linezolid, zyvox)

Front 47

These drugs are bactericidal

Back 47

Aminoglyosides, nucleic acid inhibitors, cell wall synthesis inhibitors, drugs that affect cell membrane permeability

Front 48

These drugs are bacteriostatic

Back 48

All inhibitors of protein synthesis except aminoglycosides (chloramphenicol and mupirocin can have -cidal effects)

Front 49

Bone marrow problems, and, rarely, induction of aplastic anemia

Back 49

Chloramphenicol

Front 50

Inhibits peptidyl transferase

Back 50

Clindamycin

Front 51

Useful treatment for MRSA

Back 51

Mupirocin

Front 52

Inhibits protein synthesis via a mechanism other than interacting with ribosomal subunits

Back 52

Mupirocin

Front 53

Antibiotic of choice against anthrax

Back 53

Ciprofloxacin

Front 54

These are inhibitors of DNA replication

Back 54

Quinolones (ciprofloxacin, moxifloxacin)

Front 55

These drugs bind and inhibit DNA gyrase

Back 55

Quinolones (ciprofloxacin, moxifloxacin)

Front 56

These drugs should not be prescribed for pregnant women or children because they dmg growing bone

Back 56

Quinolones (ciprofloxacin, moxifloxacin)

Front 57

This drug inhibits DNA synthesis by directly binding DNA and fragmenting it

Back 57

Metronidazole

Front 58

These drugs are also used to treat protozoal infections

Back 58

Metronidazole, sulfonamides

Front 59

This drug may also permeabilize protoplasts and inhibit RNA synthesis

Back 59

Vancomycin

Front 60

Its action requires aerobic conditions

Back 60

Metronidazole

Front 61

This drug is activated by an e- transport protein, ferredoxin

Back 61

Metronidazole

Front 62

RNA synthesis inhibitor

Back 62

Rifampin

Front 63

Used against TB in conjunction with other drugs

Back 63

Rifampin

Front 64

Efficiently secreted in saliva, and therefore makes a good prophylactic against infectious bacteria that enter via the nasopharyngeal route

Back 64

Rifampin

Front 65

Resistance to these drugs is by enzymes that modify the structure of the drugs

Back 65

Aminoglycosides

Front 66

Resistance is by acetylation by a bacterial enzyme

Back 66

Chloramphenicol

Front 67

Resistance is by hydrolysis of a lactone ring

Back 67

Erythromycin

Front 68

Resistance is by decreased expression of porins

Back 68

beta-lactams, chloramphenicol

Front 69

Resistance is via efflux pumps

Back 69

Tetracyclines, flucanazole

Front 70

Resistance is via alteration of target molecules

Back 70

Vancomycin

Front 71

Resistance is via alteration of target enzymes

Back 71

Methicillin, sulfonamide, trimethoprim

Front 72

These are antifungal drugs

Back 72

Flucytosine, fluconazole, ketoconazole, caspofungin, amphotericin B, nystatin

Front 73

These drugs are fungal antimetabolites

Back 73

Flucytosine

Front 74

Inhibits fungal cell MEMBRANE synthesis

Back 74

Fluconazole, ketoconazole

Front 75

Inhibits fungal cell WALL synthesis

Back 75

Caspofungin

Front 76

Inhibits fungal cell membrane permeability

Back 76

Amphotericin B, nystatin

Front 77

Converted to an active form within the bacterial cell

Back 77

Isoniazid

Front 78

Penetrates human cell membranes

Back 78

Isoniazid

Front 79

TB drugs that are bactericidal

Back 79

Isoniazid, pyrazanimide

Front 80

Often used in conjunction with polymyxin B and neomycin

Back 80

Bacitracin

Front 81

Commonly used as a topical agents, but systemic use is largely supplanted by more effective and less toxic agents

Back 81

Polymyxin B

Front 82

Requires aerobic conditions to be effective

Back 82

Aminoglycosides

Front 83

Protein synthesis inhibitor with similar spectrum of activity to penicillin G

Back 83

Erythromycin

Front 84

Taken up by phagocytes which migrate to site of infection, giving high and sustained tissue concentrations (half life of 70 hrs).

Back 84

Azithromycin

Front 85

Resistance develops very rapidly, therefore it is no longer recommended for treating MSRA

Back 85

Quinolones

Front 86

Requires mycobacteria amidase to become activated

Back 86

Pyrazinamide

Front 87

Cannot be used in high doses thereby only acts as a fungistatic agent therapeutically

Back 87

Nystatin

Front 88

Can be fungicidal or fungistatic, depending on the fungal isolate.

Back 88

Flucytosine