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32 Cards in this Set

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Penicillin Method of Action:
Method of Action:
beta lactam ring, binds PBP, inhibits transpeptidase, activates autolysins.
Penicillin MOR
MOR: beta-lactamase, change BPB, reduce porins
Cephalosporin MOA:
MOA:
beta lactam ring, binds PBP, inhibits transpeptidase, activates autolysins.
Cephalosporin MOR:
beta-lactamase, change BPB, reduce porins; ESBL
Vancomycin MOA:
MOA:
cell wall synthesis inhibition, binds D-ala-D-ala
Vancomycin MOR:
MOR:
encode D-ala-D-lactate
Aminoglycoside MOA:
MOA: binds 30S, inhibits iniation complex formation
Aminoglycoside MOR:
MOR: plasmids with inactivating enzymes (transferases)
Fluoroquinolone MOA:
MOA: directly inhibits DNA synthesis, TopoII in GN, TopoIV in GP
Fluoroquinolone MOR:
MOR: Mutations in drug binding sites, increased efflux pumps
Chloroamphenicol MOA:
MOA:
binds to 50S, inhibitis aa-trna and transpeptidation
Chloroamphenicol MOR:
MOR:
acetyltransferases that inactivate drug
Macrolide MOA:
MOA:
binds 50S, blocks peptidyl-trna translocation from acceptor to donor site
Macrolide MOR:
MOR:
methyltransferases that inactivate it, MDR efflux pumps
Tetracycline MOA:
MOA:
binds 30S, blocks binding of aa-trna to acceptor site
Tetracycline MOR:
MOR:
efflux pumps and decreased porin
Linozelid MOA:
MOA:
Binds 50S, blocking formation of initation complex
Synercid MOA:
MOA:
binds 50S, blocks extrusion of nascent peptide
Pen Toxicities
anaphylaxis, NVD, hemolytic anemia, urticaria, interstitial nephritis
Cephalosporin Tox
hypersensitivity, disulfiram-like
Vancomycin Tox
red man syndrome, nephrotoxic, ototoxic
AG Tox
ototox, nephrotox, neuromuscular blockade, PregD
FQ Tox
NVD, phototox, candidiasis, PregC
Chloroamphenicol Tox
NVD, grey baby syndrome, PregC
Macrolide Tox
inhibit CyP450, PregC
Tetracycline Tox
candidiasis, PregD
Linezolid Tox
thrombocytopenia
Streptogramin tox
joint pain
Sample AG's
gentamycin, amikacin, tobramycin, streptomycin
Sample Tetracyclines
tetracycline, doxycycline
Sample Macrolides
erythromycin, azithromycin, clarithromycin
FQ's
floxacins