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32 Cards in this Set
- Front
- Back
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Penicillin Method of Action:
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Method of Action:
beta lactam ring, binds PBP, inhibits transpeptidase, activates autolysins. |
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Penicillin MOR
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MOR: beta-lactamase, change BPB, reduce porins
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Cephalosporin MOA:
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MOA:
beta lactam ring, binds PBP, inhibits transpeptidase, activates autolysins. |
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Cephalosporin MOR:
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beta-lactamase, change BPB, reduce porins; ESBL
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Vancomycin MOA:
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MOA:
cell wall synthesis inhibition, binds D-ala-D-ala |
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Vancomycin MOR:
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MOR:
encode D-ala-D-lactate |
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Aminoglycoside MOA:
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MOA: binds 30S, inhibits iniation complex formation
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Aminoglycoside MOR:
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MOR: plasmids with inactivating enzymes (transferases)
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Fluoroquinolone MOA:
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MOA: directly inhibits DNA synthesis, TopoII in GN, TopoIV in GP
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Fluoroquinolone MOR:
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MOR: Mutations in drug binding sites, increased efflux pumps
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Chloroamphenicol MOA:
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MOA:
binds to 50S, inhibitis aa-trna and transpeptidation |
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Chloroamphenicol MOR:
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MOR:
acetyltransferases that inactivate drug |
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Macrolide MOA:
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MOA:
binds 50S, blocks peptidyl-trna translocation from acceptor to donor site |
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Macrolide MOR:
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MOR:
methyltransferases that inactivate it, MDR efflux pumps |
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Tetracycline MOA:
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MOA:
binds 30S, blocks binding of aa-trna to acceptor site |
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Tetracycline MOR:
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MOR:
efflux pumps and decreased porin |
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Linozelid MOA:
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MOA:
Binds 50S, blocking formation of initation complex |
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Synercid MOA:
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MOA:
binds 50S, blocks extrusion of nascent peptide |
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Pen Toxicities
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anaphylaxis, NVD, hemolytic anemia, urticaria, interstitial nephritis
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Cephalosporin Tox
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hypersensitivity, disulfiram-like
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Vancomycin Tox
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red man syndrome, nephrotoxic, ototoxic
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AG Tox
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ototox, nephrotox, neuromuscular blockade, PregD
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FQ Tox
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NVD, phototox, candidiasis, PregC
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Chloroamphenicol Tox
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NVD, grey baby syndrome, PregC
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Macrolide Tox
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inhibit CyP450, PregC
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Tetracycline Tox
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candidiasis, PregD
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Linezolid Tox
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thrombocytopenia
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Streptogramin tox
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joint pain
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Sample AG's
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gentamycin, amikacin, tobramycin, streptomycin
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Sample Tetracyclines
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tetracycline, doxycycline
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Sample Macrolides
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erythromycin, azithromycin, clarithromycin
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FQ's
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floxacins
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