Micro Nath Cns Infections

Front 1

Hx: fever, headache, neck stiffness, and altered mental status; Kernig's/Brudzinski's sign other focal neurologic findings, rash, headache, seizures + myalgia; CSF: WBC > 2000 or PMNs > 1200; glucose < 34, protein > 220

CSF gram stain of the most likely pathogen of ABM in a 6 mos-6yr old (or adults > 50 years) should reveal

CSF gram stain of the most likely pathogen of ABM in an older child
or young adult should reveal

Back 1

Acute bacterial (pyogenic) meningitis (ABM).

Gram-positive diplococcus

Gram-negative diplococcus

Front 2

Most common cause of sepsis/meningitis in newborns/neonates?

Back 2

Streptococcus agalactiae

Front 3

Cause of fever, headache, photophobia, nausea/vomiting,
rash, diarrhea, meningeal signs, in older children in the summer
months; CSF with 10-<1,000 WBC typical, mostly monos, moderately elevated protein?

Back 3

Enteroviruses (aseptic meningitis)

Front 4

Cause of aseptic meningitis in men with exposure to rodents?

Back 4

Leptospira interrogans

Front 5

Cause of aseptic meningitis with hx of tick bite and erythema migrans?

Back 5

Borrelia burgdorferi

Front 6

Cause of aseptic meningitis with hx of sex with multiple partners; CSF PCR(+)?

Back 6

HSV-2 > 1

Front 7

Cause of fever, headache, photophobia, meningismus, in pts
w/ solid organ transplant, malignancy, corticosteroid use. CSF
glucose < 2/3 serum glucose, elevated protein, WBC > 5 with PMNs?

Back 7

Listeria monocyotgenes

Front 8

How does Listeria monocytogenes differ from other #- hemolytic bacteria?

Back 8

Gram-positive rods; tumbling
motility

Front 9

Cause of chronic meningoencephalitis in a pt, who uses infliximab or native from endemic region; PE: papilledema. CXR (+). Lab: elevated monocytes on differential, low CSF glucose?

Back 9

Mycobacterium tuberculosis

Front 10

Test to confirm subacute mengoencephalitis in a,
immunocompromised pt (CD4 <100); vesicular skin lesions [CSF
profile: protein 30-150mg/dl, monos 10-100]?

Back 10

CSF India ink

Front 11

Cause of meningoencephalitis after a hx of respiratory illness after travel to SW USA?

Back 11

Coccidioides immitis

Front 12

Test to confirm CNS pathology with fever, cognitive
deficits, focal neurologic signs, seizures; temporal lobe involvement on MRI. Lab: no papilledema, CT (no brain lesion)?

Back 12

CSF PCR (+)

Front 13

Cause of fever, cognitive deficits, focal neurologic signs,
seizures, abnormal mental status with ataxia, hemi-paresis, in a pt
w/ AIDS?

Back 13

JC virus > HHV-6

Front 14

Cause of fever, cognitive deficits, focal neurologic signs, seizures or abnormal mental status with ataxia in an adult during outdoor activity?

Back 14

West-Nile virus > SLE

Front 15

Cause of fever, cognitive deficits, focal neurologic signs,
seizures, in a pt w/ AIDS (CD4 < 100). Brain CT or MRI: multifocal (ring-enhancing) lesions, affecting basal ganglia; Pt
receives pyrimethamine + leucovorin + sulfadiazine for life

Back 15

Toxoplasma gondii (TE)

Front 16

Cause of confusion, stiff neck, irritability over wks to months, in immunocompromised pts; CT or MRI = multifocal lesions in midbrain, brain stem, & cerebellum; wet mount CSF = motile macrophage-like organisms.

Back 16

Acanthamoeba spp. (GAE)

Front 17

Cause of severe headache and other meningeal signs, fever,
vomiting, and focal neurologic deficits, frequently progressing to
coma, in a healthy boy (summer diving activity)?

Back 17

Naegleria fowleri (PAM)

Front 18

Cause of seizures, chronic headache, symptomatic hydrocephalus, in immigrants from Mexico, Central or S. America); pt. successfully responds to praziquantel + anti-convulsant drug?

Back 18

Taenia solium
(neurocysticercosis)

Front 19

Hx of fever, lymphadenopathy, chancre, and pruritus weeks
ago, in a pt from Africa, progressing to headaches, somnolence,
abnormal behavior; pt. responds slowly to pentamidine isothionate
or suramin. TOW?

Back 19

Trypanosoma brucei (sleeping
sickness)

Front 20

Hx of rigidity, muscle spasm, and autonomic dysfunction.
Trismus or lock jaw due to masseter spasm in an infant w/
umbilical stump infection (secondary to poor birth delivery hygiene). Clostridial toxin interferes w/

Back 20

GABA and glycine

Front 21

Hx of foodborne (chili) afebrile illness w/ diplopia,
dysarthria, dysphoria, dysphagia, alert, and descending flaccid
paralysis in a pt w/ IDU skin poppers with black tar heroin. Clostridial toxin blocks the release of

Back 21

acetylcholine

Front 22

Immediate treatment of a male infant w/ constipation, a weak cry, and drooling, hypotonea and cranial neuropathy, after ingestion of home-processed honey.

Back 22

Equine immune globulin (infant botulism)