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14 Cards in this Set

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antibiotic neumonics
Wendy's Double Vag Brought Lookers

Mark Probably Doubled

Phil And Thomas Made O-faces

Ned Started Touching Rachel's Quality Nipples
drugs that interfere w/ cell wall
1)D cycloserine (D-Ala analogue)(TB)
(inhib L-Ala racemase/D-A-d-A synth

2)Vancomycin (G+) (injures cyto mem)
bind D-A-D-A, block polymerization

3)Bacitracin
block lipid carrier regeneration

4)B-lactams (penicillin, cephalosporins)
D-A-D-A analogue, bind PBP,stops
crosslinking(transpeptidase)
Membrane active antibiotics
1)Polymixins (G-)-->Lipid A, CIDAL

2)Daptomycin (G+) K leakage, CIDAL
(res staphyl/strept-ococci)
Inhibitors of prot synth
1)Aminoglycosides (irrev. cidal)
(streptomycin, kanamycin,
gentamicin, tobrmycin)
(30S-missreading,seperate ribo/RNA)

2)Tetracyclines (revers. no kill)
(30S-inhib aa-t-RNA from A site

3)Macrolides(rev, no kill)
(erythromycin, clindamycin,
Clarithromycin, azithromycin)
(50S-block peptidyl trans/transloca.)

4)Oxazolidinones(dep on org)
(Linezolide)(G+ only)
(23S-stop initiation complex)
staphylococci/enterococci=static
streptococci=cidal
inhibitors of Nuc acid metabolism
1)Sulfonamides (not microbial product)
Not anibiotic,inhibit PABA(folic acid)

2)trimethoprim (synergistic w/sulfa)
(inhib dihydrofolic reductase)

3)Rifamycins (Rifampin)
bind b subunit of RNA pol(blocks)

4)Quinolones(inhib gyrase a subunit,
refoming of phosphodiester bond)

5)Novobiocin (blocks bind of ATP to
gyrase/DNA complex(b func)-->less
supercoiling
external structures
S-layer
polysaccharide coating(capsul,slime)
pili (G-)
flagilla
antigenic variation
gram stain
crystal violet
iodine
ethanol
safranin
sphere organization types
diplo-pair
strepto-chain
tetrad-2
sarcina-3
staphylo-random
oxygen characteristics
Obligate anaerobes
aerotolerant anaerobes
facultative anaerobes
obligate aerobes
microaerophilic orgs
resistence general
genotypic-new/altered gene-(prevent entry, pump out, alter drug, alter target)

phenotypic-metabolic state of organism is altered, or just don't change gene (pulmonary surfactant protects from daptomycin)
resistence to inhibitors of peptidoglycan crossL. and cell wall metab.
1)Penicillin-(GENOTYPIC)
-mut of PBP's
-enzym cleavage of b-lact.
(PLASMID gene) *Most common
-extended spec of b-
lactamase=CHROME modification
(cephalosporins and G-)
-mut to prevent entry(porin)

2)Vancomycin-(GENOTYPIC)
-sub D-A-D-Lactate for D-A-D-A
(copmlex), Mobile genetic element
on entercocci->can give to
staphylococci
resistence to membrane active antibiotics
Daptomycin-(PHENOTYPIC)
in lungs, pulmonary surfactant
protects it
resistance to prot synth inhibitors
1)Aminoglycosides (GENOTYPIC)
-(Plasmid) enzyme-->modify antibio,
lowers uptake/in vitro activity
-(chrom)altered 30S target (rare)

2)Tetracylines (GENOTYPIC)
-altered 30S (rare)
-(plasmid)inc. efflux=less uptake
-(plasmic)transposon modify ribo

3)Macrolides (GENOTYPIC)
-(plasmid)23S RNA methylase-->dec.
binding to 50S
-(chrome) altered ribo

4)Oxazolidinones (GENOTYPIC)
-mut of 23S RNA-many spots
resistence to nuc acid metabolism inhibitors
1)Sulfonamides (PHENOTYPIC)
-purulent or destroyed tissue=lots
of NA bases

2)trimethoprim

3)Rifamycin (GENOTYPIC)
-mut=RifR