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11 Cards in this Set
- Front
- Back
A decrease in leukocyte number and function, as can occur in chronic granulomatous disease or granulocytopenia, will increase infection with what pathogens
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Extracellular bacteria and opportunistic fungi
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A decrease in reticuloendothelial system function, as can occur with splenectomy, will increase infection what pathogens
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Pneumococcus, and other encapsulated bacteria
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What are some characteristics of "B-1" B cells
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Produced early in development
Express characteristic cell surface markers (CD5) Have a limited V-region diversity Have a general affinity for many polysaccharide antigens Contribute significantly to the antibody response to encapsulated bacteria |
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Recurrent Neisserial infections indicates what immunodeficiency
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Defiency in terminal components of the complement cascade
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Recurring infections with Salmonella, Listeria, Mycobacterium, Legionella, or Nocardia asteroides indicate what immunodeficiency
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Infections with intracellular bacteria are typical of patients with defects in cell-mediated immunity (CMI)
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Recurring infections with Staphy aureus and Beta hemolytic streptococci, Strep pneumo, Enterobacteriaceae, Pseudomonas, or Haemophilus flu indicate what immunodeficiency
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Infections with encapsulated extracellular bacteria are common among patients with deficiencies in components of the opsonization-phagocytosis pathway
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There is no memory response to what type of antigen
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TI-2 antigens. There is no T cell help for T-indepedent antigens, so there will be IgM isotype only, and no production of memory B cells
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Recurrent viral infections indicates what immunodeficiency
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Defects in cell-mediated immunity (CMI) leave patients vulnerable to infection with most types of viruses.
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Recurrent infection with enteroviruses indicates what type of immunodeficiency
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Patients with antibody deficiency are also more vulnerable to certain types
of viral infections, particularly enteroviruses. |
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Recurrent systemic infections with Candida, and recurrent infections with Aspergillus or Phycomyces, indicates what immunodeficiency
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Patients with defects in phagocytic mechanisms are vulnerable to infection with these fungal species.
They lack direct recognition and killing of specific fungi by neutrophils |
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Patients with recurrent infections with Cryptococcus, Coccidioides, Histoplasma, and Pneumocystis, as well as chronic mucocutaneous Candida, likely have what immunodeficiency
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Patients with defects in cell-mediated immunity are vulnerable to infection with a distinct subset of fungal species.
T cell production of cytokines, causes inflammation, augmenting innate immunity (e.g., microbicidal production of nitric oxide) |