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11 Cards in this Set

  • Front
  • Back
A decrease in leukocyte number and function, as can occur in chronic granulomatous disease or granulocytopenia, will increase infection with what pathogens
Extracellular bacteria and opportunistic fungi
A decrease in reticuloendothelial system function, as can occur with splenectomy, will increase infection what pathogens
Pneumococcus, and other encapsulated bacteria
What are some characteristics of "B-1" B cells
Produced early in development
Express characteristic cell surface markers (CD5)
Have a limited V-region diversity
Have a general affinity for many polysaccharide
Contribute significantly to the antibody response
to encapsulated bacteria
Recurrent Neisserial infections indicates what immunodeficiency
Defiency in terminal components of the complement cascade
Recurring infections with Salmonella, Listeria, Mycobacterium, Legionella, or Nocardia asteroides indicate what immunodeficiency
Infections with intracellular bacteria are typical of patients with defects in cell-mediated immunity (CMI)
Recurring infections with Staphy aureus and Beta hemolytic streptococci, Strep pneumo, Enterobacteriaceae, Pseudomonas, or Haemophilus flu indicate what immunodeficiency
Infections with encapsulated extracellular bacteria are common among patients with deficiencies in components of the opsonization-phagocytosis pathway
There is no memory response to what type of antigen
TI-2 antigens. There is no T cell help for T-indepedent antigens, so there will be IgM isotype only, and no production of memory B cells
Recurrent viral infections indicates what immunodeficiency
Defects in cell-mediated immunity (CMI) leave patients vulnerable to infection with most types of viruses.
Recurrent infection with enteroviruses indicates what type of immunodeficiency
Patients with antibody deficiency are also more vulnerable to certain types
of viral infections, particularly enteroviruses.
Recurrent systemic infections with Candida, and recurrent infections with Aspergillus or Phycomyces, indicates what immunodeficiency
Patients with defects in phagocytic mechanisms are vulnerable to infection with these fungal species.
They lack direct recognition and killing of specific fungi by neutrophils
Patients with recurrent infections with Cryptococcus, Coccidioides, Histoplasma, and Pneumocystis, as well as chronic mucocutaneous Candida, likely have what immunodeficiency
Patients with defects in cell-mediated immunity are vulnerable to infection with a distinct subset of fungal species.
T cell production of cytokines, causes inflammation, augmenting innate immunity (e.g., microbicidal production of nitric oxide)