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19 Cards in this Set
- Front
- Back
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why are there fewer antiviral drugs compared to antibacterial? (3)
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1. selective toxicity is mandatory b/c viral infection involved host cells
2. infecton may be advanced before it is detected 3. rapid mutation of viruses |
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what are targets of antiviral agents? (6)
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block attachment/penetration;
block uncoating block NA syn block protein syn block assembly block release |
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what block attachment, penetration?
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fusion inhibitors;
receptor antagonists |
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what blocks uncoating?
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neutralizing agents;
crosslinking agents; |
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what blocks NA syn?
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base analogs
agents that inhibit nucleotide syn, DNA polym, reverse transcriptase |
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what blocks protein syn?
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interferons!
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what blocks assembly?
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protease inhibitors
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what blocks release?
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neuraminidase and hemagglutinin inhibitors
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resistance to antiviral agents? (3)
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mutated target
alter drug decr uptake (if required intracellularly) |
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Fusion inhibitor (1)
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Enfuviritide (Fuzeon)
-for HIV |
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neutralizing agents (2)
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Amantadine
Rimantadine |
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base analog (mxn?)
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AZT (nucleoside RT inhibitor)
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inhibit nucleotide bisyn (1)
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Ribavirin
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ribonucleoside analog (1)
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RSV
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inhibit viral DNA polymerase (2)
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Acyclovir
Ganciclovir |
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inhibit reverse transcriptase (mxn?) (1)
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Nevirapine (non-nucleoside HIV RT inhibitor)
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inhibit protein syn
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interferon alpha
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protease inhibitor (1)
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Ritonavir
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inhibit Neruaminidase, Hemagglutinin (1) (mxn?)
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Zanamivir (removes sialic acid on host cell to prevent re-infection after release of new virions)
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