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19 Cards in this Set

  • Front
  • Back
why are there fewer antiviral drugs compared to antibacterial? (3)
1. selective toxicity is mandatory b/c viral infection involved host cells
2. infecton may be advanced before it is detected
3. rapid mutation of viruses
what are targets of antiviral agents? (6)
block attachment/penetration;
block uncoating
block NA syn
block protein syn
block assembly
block release
what block attachment, penetration?
fusion inhibitors;
receptor antagonists
what blocks uncoating?
neutralizing agents;
crosslinking agents;
what blocks NA syn?
base analogs
agents that inhibit nucleotide syn, DNA polym, reverse transcriptase
what blocks protein syn?
interferons!
what blocks assembly?
protease inhibitors
what blocks release?
neuraminidase and hemagglutinin inhibitors
resistance to antiviral agents? (3)
mutated target
alter drug
decr uptake (if required intracellularly)
Fusion inhibitor (1)
Enfuviritide (Fuzeon)
-for HIV
neutralizing agents (2)
Amantadine
Rimantadine
base analog (mxn?)
AZT (nucleoside RT inhibitor)
inhibit nucleotide bisyn (1)
Ribavirin
ribonucleoside analog (1)
RSV
inhibit viral DNA polymerase (2)
Acyclovir
Ganciclovir
inhibit reverse transcriptase (mxn?) (1)
Nevirapine (non-nucleoside HIV RT inhibitor)
inhibit protein syn
interferon alpha
protease inhibitor (1)
Ritonavir
inhibit Neruaminidase, Hemagglutinin (1) (mxn?)
Zanamivir (removes sialic acid on host cell to prevent re-infection after release of new virions)