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16 Cards in this Set

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what limits the effectiveness of antiparasitic agents? (3)
-low selective toxicity (b/c also eukaryotic)
-cuticles
-complex life cycle (may req more than one drug)
what are 5 targets for antiparasitic drugs?
folic acid biosyn
DNA replication
Protien syn
neuromediators (paralysis)
transport (prevent uptake of nutrients)
classes of drugs that inhibit DNA replication (3)
Animoquinoline analogs
Diamidines
Nitroimidazoles
ex and MOA of animoquinoline analogs?
ex: chloroquine
interfere with DNA replication
digest Hb
ex and MOA of Diamidines?
ex: Pentamidine
bind DNA and prevent syn
ex and MOA of Nitroimidazoles
ex: Metronidazole
inhibits DNA syn
class of folic acid biosyn inhibitor
pyrimethamine
protein syn inhibitor; mxn
paramomycin
binds ribosome
class that disrupts transport
benzimidazole
ex of benzimidazole and mxn
ex: mebendazole
inhibits glucose transport, fumarate reductase (only in parasites), microtubules
4 classes that inhibit neuromuscular action
tetrahydropyrimidines
piperazines
avermectins
pyrazinoisoquinolines
ex and MOA of tetrahydropyrimidines
ex: Pyrantel pamoate
blocks n/m action, fumarate reductase
ex and MOA of piperazines
ex: Piperazine
GABA antagonist; stimulate phagocytes
ex and MOA of Avermectins
ex: Ivermectin
block n/m action
GABA antagonist
ex and MOA of pyrazinoisoquinolines
ex:Praziquantel
calcium agonist~tetany (n/m)
tegumental disruption
resistance to antiparasitic agents (4)
efflux mxn
mutation in target
alternative pathways
alter life cycle