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16 Cards in this Set
- Front
- Back
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what limits the effectiveness of antiparasitic agents? (3)
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-low selective toxicity (b/c also eukaryotic)
-cuticles -complex life cycle (may req more than one drug) |
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what are 5 targets for antiparasitic drugs?
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folic acid biosyn
DNA replication Protien syn neuromediators (paralysis) transport (prevent uptake of nutrients) |
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classes of drugs that inhibit DNA replication (3)
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Animoquinoline analogs
Diamidines Nitroimidazoles |
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ex and MOA of animoquinoline analogs?
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ex: chloroquine
interfere with DNA replication digest Hb |
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ex and MOA of Diamidines?
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ex: Pentamidine
bind DNA and prevent syn |
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ex and MOA of Nitroimidazoles
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ex: Metronidazole
inhibits DNA syn |
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class of folic acid biosyn inhibitor
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pyrimethamine
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protein syn inhibitor; mxn
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paramomycin
binds ribosome |
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class that disrupts transport
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benzimidazole
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ex of benzimidazole and mxn
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ex: mebendazole
inhibits glucose transport, fumarate reductase (only in parasites), microtubules |
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4 classes that inhibit neuromuscular action
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tetrahydropyrimidines
piperazines avermectins pyrazinoisoquinolines |
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ex and MOA of tetrahydropyrimidines
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ex: Pyrantel pamoate
blocks n/m action, fumarate reductase |
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ex and MOA of piperazines
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ex: Piperazine
GABA antagonist; stimulate phagocytes |
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ex and MOA of Avermectins
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ex: Ivermectin
block n/m action GABA antagonist |
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ex and MOA of pyrazinoisoquinolines
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ex:Praziquantel
calcium agonist~tetany (n/m) tegumental disruption |
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resistance to antiparasitic agents (4)
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efflux mxn
mutation in target alternative pathways alter life cycle |
