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14 Cards in this Set

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why are fungi hard to get rid of by the host's own defense mxn?
host (mammals) dont have enzymes to break down cell wall polysaccharides of fungi
why is it difficult to target fungi with antimicrobials?
b/c fungi are also eukaryotic and most drugs will have serious side effects on host (most drugs are topical to keep effects local)
what is a good target on fungi that distinguishes them from host cells?
ergosterol in the cell mbr!
(mammals have cholesterol)
antifungal drug classes? (4)
polyenes
imidazoles
echinocandins
base analogs
mxn polyenes
insert next to ergosterol and form pore
mxn imidazoles
target cyt P450 demethylase (req for ergosterol syn)
mxn echinocandins
inhibit glucan syn
mxn base analogs
inhibit RNA, DNA fxn
narrow spectrum
how do topical drugs improve treatment?
provide selective toxicity;
prevent systemic adverse side effects
resistance to antifungal agents (3)
decr permeability
active efflux
decr syn of target
DEP ON MUTATIONS
polyenes (2)
Amphotericin B
Nystatin
imidazoles (2)
Ketoconazole
Fluconazole
echinocandins (1)
Caspofungin
base analogs (1)
Flucytosine