Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
Non-lactose fermenters on MacConkey agar
|
salmonella, shigella, yersenia, campylobacter
|
|
Do E coli ferment lactose?
|
Yes
|
|
Most common cause aseptic meningitis
|
enterovirus
|
|
How do + strand RNA viruses replicate?
|
+ strand RNA = mRNA, can be immediately translated. First translate proteins for the viral replicase, which is an RNA-dependent RNA polymerase to make + into -, then to +. + strands can be used to make proteins, amplify infection, or be template for more - strand
|
|
How do enteroviruses infect the CNS?
|
ingest fecal material -> virus infects mucosal + lymphoid cells in pharynx/intestine (1* viremia)-> start excreting in feces, seeds to extraneural cells -> either cross BBB in WBC, or via retrograde axonal transmission
|
|
Salk created which vaccine?
|
IPV (killed virus, get IgM/IgG, no reversion, but poor mucosal immunity)
|
|
Herpes virus structure? Where do they replicate?
|
Icosahedral capsid, surrounded by envelope, linear ds DNA. Replicate in nucleus
|
|
How are herpes viruses spread?
|
need close contact, like between mucosal surfaces, b/c they are fragile and don't survive well outside of body
|
|
Three classes of herpes viruses and examples
|
Classified by biologic/molecular methods. Alpha = HSV-1,2, VZV (grow rapidly, lyse infected cells, latent in sensory ganglia). Beta - CMV (slow growth, lysis slow, latent in WBC). Gamma - EBV (replicate in lymphoid, some lytic. Latent in B cells)
|
|
Replication cycle for herpes
|
glycoproteins on envelope tether to cell surface receptors -> fuse -> capsid/virus to cytoplasm -> to nucelus -> vmRNA made by host (IE,E,L). Capsid assembles in nucleus, get envelope from nucleus,
|
|
Criteria for viral latency
|
can detect viral DNA but no infectious viruses
|
|
Genes expressed during latency
|
no viral antigens or capsids, but some low-level transcription of other genes
|
|
VZV pathogenesis
|
spread by droplet nuclei or direct contact w/ lesions -> infect lymphoid tissue in pharynx -> viremia infects multiple organs and skin -> proceeds up local sesnory nerves to establish latency in ganglia
|
|
Pathogenesis of herpes zoster
|
latent VZV present, periodically reactivates, usually quelled by T cells. Immunity decr w/ age, so virus can travel back down nerve -> illness. This boosts immunity again so only get 1 case/lifetime
|
|
Which streptococci are resistant to penicillins
|
enterococci
|