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26 Cards in this Set
- Front
- Back
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what can lead to hepatitus other than Hep A B C D E in immunocomprimised
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human herpers viruses espeacially CMV
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which hepatitis viruses have RNA genomes
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A
C D E |
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which hep viruses are naked icosahedral
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picorna hep a
calici like hep E |
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which hep virus is lipid enveloped
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hep c
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how long after exposure do u show symptoms of hep A
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1 to several months
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how do u diagnos hep A
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antibody capture ELISA/EIA to detect serum anti -HAV IgM indicative of current/recent infections
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what is antiviral IgG indicative of
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past infection
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hep A is what type of immunization
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active immunization with inactiveated virus
passive immunization with normal human IG for post exposure protection |
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what type of virus is hep E
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small nakes icosohedral
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where is hep E common
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parts of africa, latin america, asia
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what is the key diagnostic test for Hep B
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HBsAg
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what is anti-HBc IgM
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acute infection
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what indicates chronic hep B infection
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+IgG with - IgM in the presence of HBsAg
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what is the presence of HBeAg mean
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high level of infectivity
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what does anti-HBs IgG indicate
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indicates past infection if there is anti-HBc IgG
or immunization if no anti-HBc IgG |
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nucleic acid based assays and polymerase chain reactinos or branched chain DNA assays are used to do what?
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quantitate viral DNA genome to deteremine viral load in a person with known hep B this will guide choice to undergo therapy or not.
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what is the immunization for hep B
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active immunization with recombinatn HBsAg
passive immunization with HBIG for post exposure prophylaxis for non immune or for people who immunization doesnt work |
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how do you diagnose hep C
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antibody capture ELISA/EIA to detect anti HCV
confirm with RIBA |
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what is the therapy for HBV and HCV
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inferon alpha reccommended for chronic B and C
pegylated IFN-alpha longer lasting and requires only one injection/ week instead of 3 NRTIs from chronic HBV lamivudine ribavirin in combination with IFN alpha fro chronic HCV |
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what are the main characteristics of HAV-HEV
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majoritey of infections are asympotmatic or mild without jaundice
jaundine in only 20-50% |
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what is the preicteric phase
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3-10 days malaise and weakness, follwoed by anorexia, nausea and vomiting dull pain in right upper quadrant
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what is the icteric phase
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1-3 wekks juandice and or dark urine dramitic increase in aminotransferases
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when are you infective with hepatitis
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in incubation
precteric and first week or two of icteric phase |
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what is the convalescent phase
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malaise and weakness may persist for weeks with relapse or prolonged illness up to six months with HAV
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what is the major cause of mortality in acute viral hepatiitis
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fulminant hepatitis rare
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what types of hep C are most common in the US
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1a and 1b which are the one that are least responsive to treatment best treatment is rebetron plus protease inhibitor
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