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60 Cards in this Set

  • Front
  • Back
HHV 3
VZV
HHV 4
EBV
HHV 5
CMV
HHV 6
roseola (fever then rash, exanthem subitum)
HHV 8
Kaposi's sarcoma
Hepadnavirus
Hep B
Polyoma viruses (2)
JC -progressive multifocal leukenceph in HIV and BK- transplant patients, especially kidney
Colti and Rota (name family)
Reovirus
Polio, Echo, Rhino, Cocksackie, Hep A (name family)
Picornaviurs
Norwalk virus (name family)
Calicivirus
Hep C, yellow fever, dengue, St. Louis encephalitis, West Nile (name family)
Flavivirus
Rubella, equine encephalitis (name family)
Togavirus
HIV, HTLV (name family)
Retrovirus
Influenza (name family)
Orthomyxovirus
Parainfluenza, RSV, Rubeola (Measles), Mumps (name family)
Paramyxovirus
Rabies
Rhabdovirus
Ebola
Filovurs
Lymphocytic choriomeningitis virus (LCMV), lassa fever encephalitis from mice
Arenavirus
California encephalitis, Crimean-Congo hemorrhagic fever, Sandfly/Rift Valley fever, Hantavirus
Bunyavirus
RNA + stranded
Retro, Toga, Flavi, Corona, Hepe, Calici, Picorna
RNA - stranded (need RNA dependent RNA polymerase)
Arena, Bunya, Paramyxo, Orthomyxo, Filo, Rhabdo
HIV protein for attachment to T cell.

also what receptors does it bind?
gp120 (env gene)

binds CCR4 or CCR5 and CD4
HIV protein for fusion and entry
gp41 (env gene)
HIV gene for capsid
gag (p24)
HIV gene for reverse transcriptase
pol
antibiotic that blocks transpeptidase cross-linking of peptidoglycan
Penicillin, beta-lactam
Methicillin, nafcillin, dicloxacillin
blocks transpeptidase cross-linking of peptidoglycan. resistant to penicillinase. staph aureus
Ampicillin, Amoxicillin
block transpeptidase cross-linking of peptidoglycan. use with clavulanic acid to counteract beta lactamases. HELPSS: H. influenza, E. coli, Listerio, Proteus, Salmonella, Shigella
Ticracillin, Carbenicillin, Piperacillin
antipseudomonal. same mechanism as penicillin.
Clavulanic acid, sulbactam, tazobactam
beta lactamase inhibitors
LAME
organisms not covered by cephalosporins: listeria, atypicals (Chlamydia, mycoplasm), MRSA, and enterococci
Cephazolin, Cephalexin
1st generation cephalosporins: proteus, E. coli, Klebsiella
Cefoxitin, Cefaclor, Cefuroxime
2nd generation cephalosporins: H. influenza, Enterobacter, Neisseria, Proteus, E. coli, Klebsiella, Serratia
Ceftriaxone, Cefoxatime, Ceftazidime
3rd generation cephalosporins: ceftriaxone = meningitis, gonorrhea; ceftazidime = pseudomonas
Cefepime
4th generation cephalosporin. pseudomonas and gram +
disulfuram like reaction with alcohol
cephalosporins; metronidazole
resistant to beta lactamases, inhibits cell wall synthesis by binding PBP3. gram negative rods only
aztreonam
beta lactamase resistant carbapenem always given with cilastatin (inhibits renal dehydropeptidase 1). toxic to CNS in high doses
Imipenem
Inhibits cell wall mucopeptide formation via D-ala D-ala. Drug resistant gram positives only.
Vancomycin
red man syndrome. nephrotox, ototox, thrombophlebitis
Vancomycin
Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin
Aminoglycosides. inhibit formation of initiation complex via 30S. requires oxygen for uptake. Gram negs. bactericidal.
Tetracycline, Doxycycline, Demeclocycline
Tetracyclines. bind 30S. don't take with milk, antacids. Borrelia, Mycoplasma, Rickettsia, Chlamydia. teeth discoloration. Demeclocycline = ADH antag. static
Erythromycin, Azithromycin, Clarithromycin
Macrolides. block translocation "slides". static. Atypical pneumonia, Neisseria, gram + in allergic. Prolong QT, GI
Chloramphenicol
blocks peptide bonding at 50S. static. Meningitis (H. influenza and Neisseria). aplastic anemia, gray baby syndrome due to lack of liver UDP glucuronyl transferase
Clindamycin
blocks 50S. static. Anaerobes above diaphragm. Causes C. difficile overgrowth/pseudomembranous colitis
Sulfamethoxazole, sulfisoxazole sulfadiazine
Sulfonamides. Inhibits dihydropteroate synthetase via PABA antimetabolite. static. hemolysis in G6PD, nephrotoxic
Trimethoprim
inhibits bacterial dihydrofolate reductase. static. UTIs, Shigella, Salmonella, Pneumocystis jiroveci. megaloblastic anemia, leukopenia. Use leukovorin rescue.
Ceprofloxacin, Norfloxacin, LEvofloxacin, Ofloxacin, Sparfloxacin, Enoxacin, Nalidixic Acid
Fluoroquinolones. inhibit DNA gyrase (topo II). cidal. don't take with antacids. gram negative rods in urinary and GI. Damage cartilage and tendons. don't give in pregnancy.
Metronidazole
free radical toxic metabolite damages DNA. cidal. antiprotozoal. Giardia, Entamoeba, Trichomonas, Gardneralla, Anaerobes (bacteroides, C. diff**), in triple therapy for H. pylori (+bismuth+amoxicillin)
TB treatment
Isoniazid, Rifampin, Pyrazinamide, Ethambutol
M. avium treatment
Azithromycin (prophylactic), Rifampin, ethambutol, streptomycin
Isoniazid
decreases mycolic acid synthesis. activated by catalase-peroxidase. INH--neurons and hepatocytes. Give B6 to protect neurons
Rifampin
RN pol inhibitor. meningococcal and H. influenza prophylaxis. increases P450s and causes red/orange body fluids.
Pyrazinimide
inhibits mycolic acid production. Effective in acidic phagolysosomes where TB hangs out in macrophage
Meningococcal prophylaxis
Cipro is best, or rifampin, minocyclin
Treatment of vanco resistant bugs
linezolid and streptogramins (quinupristin)
Amphotericin, Nystatin mechanism
binds ergosterol to form pores
Azole mechanism
inhibit fungal ergosterol synthesis
Caspofungin mechanism
Inhibits fungal wall synthesis of Beta glucan
Chloroquine
blocks Plasmodium heme polymerase. causes retinopathy and G6PD issues