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210 Cards in this Set

  • Front
  • Back

A commercial modification of the disk diffusion test is called the

E Test

A number of viruses often include a similar set of symptoms when they cause an infectious disease state (fever, headache, fatigue, runny nose). Why would they all cause the same symptoms if they're different viruses?

The symptoms are associated with the immune system's response, NOT the molecules from the pathogens themselves. Our responses against viruses are fairly similar, regardless of virus type, so the symptoms are similar.

Avirulent organisms are

unable to cause disease

A new serotype of Vibrio cholerae, V. cholerae 0139, has picked up the ability to produce

capsules

How is the central portion of a T-cell receptor complex functionally analogous to the center of the B-cell receptor complex?

Both receptors bind epitopes (small amino acid sections of antigen molecules).

Fluoroquinolones typically target

DNA gyrase

If a patient received a kidney transplant that was matched well across each of the major histocompatibility complex (MHC) molecules, but they stopped taking their anti-rejection drugs, what would happen and why?

The organ will be rejected, but it will be a gradual process since it was matched well. There are a number of other proteins that cannot be matched between donors, so the graft will still be viewed as 'foreign' by the recipient's immune system, and will still be attacked. The attack will just be a slower and lengthier process.

Which of the following would be considered a sign of a disease?


fever of 39°C

Mycolic acids are targeted by isoniazid in the treatment of

M. tuberculosis.

The amount of infecting agent received by susceptible individuals is called the

dose.

Which of the following primary immunodeficiencies is the most common?

selective IgA deficiency

The process by which infectious agents are ingested by host cells is termed

endocytosis.

Generally antigenic molecules usually have a molecular weight greater than

10,000 Daltons.

Whole agent vaccines may contain


viruses AND bacteria.

The only class of antibody that can cross the placenta is

IgG

A physician is seeking ways to increase the fine-tuning of antibody immune responses that occurs naturally during affinity maturation. The goal is to create 'super antibodies' with intensely high affinity for antigens. She decides to use a drug that can be injected into lymph nodes that will be highly mutagenic specifically to B-cells that are undergoing activation. Is this a good idea? Why or why not?


It won't work. Affinity maturation is a random mutation process, followed by selection of B cells with higher affinity for the antigen in question. It doesn't matter if you increase the NUMBER of mutations-they still need to be screened for affinity to the antigen, and you can only achieve a certain level of affinity. Beyond that, and any mutations in antibody genes are just 'extra' changes without any real effect.

Which of the following members of the normal flora inhibit the growth of Candida albicans?


Lactobacillus species.

Transmission-Based Precautions

are guidelines to use with patients infected with a highly transmissible or epidemiologically important pathogen.

It would be useful if antigens were delivered directly to

Peyer's patches AND M cells.

The guidelines designed for prevention of nosocomial disease during care of all patients is called

Standard Precautions.

WHO has targeted for elimination of


polio, dracunculiasis AND measles.

Phagocytes were first discovered and named by


Metchnikoff

Which of the following is NOT a political/societal reason for a decrease in rates of childhood immunizations?

A lack of a proper 'cold chain' for stable transport of vaccines into tropical areas.

Which of the following is not a mechanical vector?

fomite

Pyrogens are

fever-inducing substances.

Gene rearrangement is responsible for the generation of the various antibody molecules.

True

T cells and B cells are manufactured in the

bone marrow

The natural antibodies in serum that react with A or B polysaccharide antigens are mostly of the class

IgM

Which is involved in reacting to virus-infected cells?


cell-mediated immunity, T cytotoxic cells AND MHC I

Bacteria may survive phagocytosis by


preventing fusion of the lysosome with the phagosome AND lysing the phagosome.

Bacteria that resist killing by complement proteins are termed

serum resistant.

A relationship in which one partner benefits and the other is unaffected is termed


commensalism.

Fever


inhibits bacterial growth AND speeds up the body's reactions.

Antimicrobials that kill microorganisms have the suffix

-cidal

Allergic reactions mainly involve

mast cells

Monoclonal antibodies obtained from a hybridoma provide

a large amount of an antibody that is specific for a particular antigen.

Following digestion of a microorganism by phagocytes, the debris is excreted by


exocytosis.

Large respiratory droplets typically travel no farther from point of release than

1 meter

Recombinant human monoclonal antibody (rhuMAb)


appears promising as a treatment for asthma AND uses an engineered form of an IgG molecule.

Would antibodies produced by a patient in response to infection be monoclonal, or polyclonal?


Since a single pathogen has multiple antigens, and each antigen has multiple epitopes, the responding antibodies to a whole pathogen would be polyclonal

Factors that work generically against any foreign substance entering the host are described as

innate immunity

CD8 cells are often

T cytotoxic cells.

There are blank classes of antibody.

5

The hypersensitivity treatment that stimulates an increase of IgG and T suppressor cells and a decrease in IgE is known as


desensitization.

Antibodies are made by

B cells/plasma cells.

Why are nucleoside analogs active only against replicating viruses?

Nucleoside analogs work by being incorporated into growing strands of DNA/RNA. This indirectly shuts down further extension of these chains. However, new strands of viral DNA/RNA are only being created when the virus is replicating. As such, these drugs can only work when the virus is actively replicating as well.

Herd immunity


occurs in a population in which a large percentage of the population is immune.

Antigens interact with antibodies at


the outer end of each arm of the Y.

Approximately what percentage of hospitalized patients may develop a nosocomial infection?

5%

Which of the following is/are secondary lymphoid organ(s)?


spleen AND lymph nodes

Trimethoprim and sulfonamides have a(n)

synergistic effect

The change from negative serum, without antibodies specific to an infecting agent, to positive serum, containing antibodies against that infecting agent, is called

seroconversion

In what clinical situation is it most appropriate to use a broad-spectrum antimicrobial?


In a case of bacterial meningitis. The infection spreads so quickly that we must treat it with an antibacterial drug as quickly as possible. We don't have time to determine which drug will work best, because the patient will die in the meantime.

Delayed type hypersensitivity primarily involves

T cells

Urticaria is characterized by

wheal and flare

Precipitation reactions depend on

the antigen having two or more epitopes.

Beta-lactamases


break the beta-lactam ring.

Which is true about superantigens?

They are a type of exotoxin AND they bind simultaneously to MHC class II antigen on an antigen-presenting cell and to the T-cell receptor on a helper T cell.

Skin and mucous membranes are mostly involved in

innate immunity

Sulfonamides work as

competitive inhibitors

The major class(es) of antibiotics that inhibit protein synthesis is/are

aminoglycosides, tetracyclines AND macrolides.

Penicillin was discovered by

Fleming

Attenuated agents

MAY INDUCE IMMUNITY AFTER A SINGLE DOSE,


MAY CAUSE DISEASE IN IMMUNOCOMPROMISED INDIVIDUALS,


MULTIPLY IN THE BODY


MAY REVERT OR MUTATE TO DISEASE-CAUSING STRAINS.

Which of the following are referred to as mononuclear phagocytes?

monocytes and macrophages

Organisms that are found together and interact on a more or less permanent basis are in a relationship termed

symbiosis

The "voices" of a cell are

cytokines

Inhibitors of protein synthesis typically key on

ribosomes

Hemolytic disease of the newborn

may not manifest itself fully until after birth

The minimum bactericidal concentration is the lowest concentration of a specific antimicrobial drug that kills blank of a specific type of bacteria.

99.9%

The four cardinal signs of inflammation are:

redness, heat, swelling, pain

Desensitization

stimulates an increase in IgG AND is a treatment for hypersensitivity reactions.

The arsenic compound that proved highly effective in treating syphilis was called

salvarsan

Delayed hypersensitivity is also known as blank hypersensitivity.

type IV

Which of the following is not typical of an antigen?

low molecular weight

Which of the following contributes to nosocomial disease?

susceptible population


hospital environment


other patients


patients own normal flora

The single most important measure to prevent the spread of disease is

hand washing

Interleukins are

produced by leukocytes and are protein molecules

Which of the following may be considered virulence factor(s)?

ADHESINS, CAPSULES, ENDOTOXINS AND PROTEASES

Insulin-dependent diabetes mellitus is an example of an autoimmune disease that involves

cytotoxic T cells

If a positive reaction is last observed at a dilution of 1:256, the titer is

256

A disease-causing microorganism or virus is referred to as a(n)

pathogen

Prontosil effectively acted on streptococci when the drug was split by enzymes to produce

sulfanilamide

Which class of antibody accounts for the bulk of the circulating antibody?

IgG

Which of the following are most susceptible to complement lysis?

gram negative bacteria

Substances with a molecular weight of less than 10,000 Daltons make good antigens.

false

The most effective form of penicillin is

G

Which of the following do not induce a strong immune response?

lipids and nucleic acids

The natural habitat of a pathogen is referred to as its

reservoir

Which of the following factors is not considered important for the establishment of an infection?

toxicity

The target of most antifungal drugs is

ergosterol

The diffusion bioassay


is similar in principal to the Kirby-Bauer test AND determines the concentration of antimicrobial in a fluid.

The tissue antigens most involved in graft rejection involve

MHC

The variable region of an antibody occurs

on all 4 chains

Syphilis was once treated by intentionally infecting the patient with the parasite that causes malaria, a disease characterized by repeated bouts of fever, shaking, and chills. Why might this treatment cure syphilis?

The effect of driving up the body temperature for periods of time can shut down the temperature-sensitive replication of the bacterium that causes syphilis. This gives the immune system time to eliminate it properly.

Which is not a component of innate immunity?

antibody

Explain how using a combination of two antimicrobial drugs helps prevent the development of spontaneously resistant mutants.


It is highly unlikely that the microbe might spontaneously develop 2 specific mutations to resist the effects of a pair of drugs. As such, even if one drug is resisted by the microbe, the 2nd drug will eliminate the mutated microbe, thus preventing the development of spontaneously resistant mutants overall.

Which of the following is true about the role normal flora plays in maintaining host health?

THEY PROVIDE A SURFACE THAT IS INCOMPATIBLE FOR ATTACHMENT OF AN INVADER,


THEY ESTABLISH COMPETITION FOR NUTRIENTS AND VITAMINS,


THEY PRODUCE ANTIMICROBIAL SUBSTANCES,


AND THEY STIMULATE THE IMMUNE SYSTEM

Which of the following is called a zoonotic disease?

plague

Which of the following antibodies is a dimer?

IgA

Substances that are contained in vaccines to help induce a better immune response are called

adjuvants

Adhesins are


involved in the first step of the infectious process AND often found at the tip of pili.

Variolation is a procedure once used to protect against

smallpox

Stem cells

have an almost unlimited capacity to divide.


can differentiate into different tissues.


may be used to test the effects of drugs on human cells.


come from fetal material.

A defect in which of the following systems leads to granulomatous disease?

oxidase system

Inanimate objects capable of transferring infectious disease agents are

fomites

The surface receptors on B and T cells both

have variable and constant regions.

Antibodies that have arisen in the blood plasma without any obvious or deliberate stimulus are called

natural

The last case of naturally contracted smallpox occurred in

1977

Proteins that react specifically with the chemical structures in the antigen that induced them are called

antibodies

Injection of a single antigen usually results in production of

a number of antibodies each recognizing a different epitope

A group of interacting serum proteins that provide a nonspecific defense mechanism is

complement

Which is the most efficient at initiating the classical pathway of the complement cascade?

IgM

Antibiotics that are most likely to disrupt the normal flora are termed

broad spectrum

Sulfonamide and trimethoprim are both

examples of metabolic inhibitors AND folate inhibitors.

A more modern equivalent to Koch's Postulates is termed


Molecular Postulates.

The interaction of all organisms within a biological community is called a(n)

ecosystem

Normal microbiota

are the organisms that typically reside on your body AND protect against infection by pathogens.

The threat of bioterrorism

is due largely to the ease of spread and severity of diseases AND may include rarely seen infectious agents.

Killing of graft cells occurs through a complex series of mechanisms including



sensitized T cytotoxic cells AND NK cells.

During a Type I hypersensitivity reaction, the mast cells


degranulate AND immediately release histamine.

When an infectious disease cannot spread in a population because it lacks a significant number of susceptible hosts, the phenomenon is referred to as

herd immunity

Which type of vaccine has been used in place of inactivated whole cell vaccine?

acellular subunit

The "hygiene hypothesis" proposes that


lack of exposure to microbes can promote development of allergies.

One of the strongest indications of infectious disease is

fever

Why do Rh-negative but not Rh-positive mothers sometimes have babies with hemolytic disease of the newborn?

This disease results when an Rh-negative mother's immune system is primed multiple times to produce anti-Rh IgG antibodies that can cross the placenta. If the mother is Rh-positive, she won't produce any anti-Rh antibodies at all.

Inactivated immunizing agents are prepared by treatment with

formalin

DNA vaccines work by

having the cell use the introduced DNA to make the microbial protein antigen.

Prevention of patient-to-personnel transmission of disease keys on limiting contact with

body fluids

Which plant has been used to deliver vaccine?

potatoes

Complement

may be activated through three pathways, disrupts the cytoplasmic membrane of invading bacteria and foreign cells AND is a group of blood proteins.

Sulfonamides are similar in structure to

PABA

Which test is used to determine the susceptibility of a microorganism to an antimicrobial?

Kirby- Bauer test

What is NOT a reason that the kidneys are particularly prone to damage caused by immune complexes?


Kidney blood vessel wall cells have receptors for antibodies on them, which makes them soak up antibodies (or in this case, immune complexes) from the bloodstream. This blocks the kidneys up and causes them to malfunction and become damaged.

Which of the following is a phagocytic cell found in the human body?

neutrophil

The series of steps used to connect an organism to a disease are known as

Koch's postulates

What would be a primary advantage of passive immunity with diseases such as tetanus or botulism?

Time. You can quickly neutralize the toxin with a passive administration of antibodies to save the patient's life when no is available for them to make their own active immune response.

Which of the following bacteria have an innate resistance to penicillin?

mycoplasma

The serology test that may show the antigen-antibody complex as yellow-green under the microscope while using an ultraviolet light is known as the

fluorescent antibody test

In which organism were phagocytes first reported?

starfish larvae

Growth of a parasitic organism in or on the host is referred to as

infection

Anti-human-gamma-globulin antiserum is often used in

indirect fluorescent antibody tests

Monoclonal antibodies may be used in the rapid diagnosis of

CHLAMYDIA,


INFLUENZA,


HEPATITIS


AND PREGNANCY

Colonization of the body is inhibited by

the shedding of skin cells.
the movement of mucus by cilia.
peristalsis.
the flushing action of the urinary tract.

The first kind of leukocyte lured to the site of inflammation is the

neutophil

Giant cells are

used to contain bacterial infections.

How do cytokines function?


They are secreted by one cell type in the vicinity of another cell. They then bind to a receptor on the 2nd cell, causing a signal within that cell that turns on (or off) certain genes to achieve a response.

An immune complex is defined as

antigen combined with antibody

The resident microbial population of the human fetus is

zero

What might be an advantage to using an individual's own stem cells instead of pancreatic cell allografts to treat Type I diabetes?


If you were able to use a person's own cells, it would be considered an autograft rather than an allograft. As such, there should be no HLA/MHC matching required, and no long-term anti-rejection drugs needed

The lowest concentration of a drug that prevents growth of a microorganism is the


minimum inhibitory concentration.

The microorganisms that are regularly found in or on the body, yet do no apparent harm are called

normal flora

Immunosuppressive drugs


are needed indefinitely after transplantation.

Explain the most likely reason why smallpox was successfully eradicated but rabies probably never will be.


Smallpox was ONLY found in humans; rabies is found in numerous animal reservoirs. We cannot reasonably eliminate rabies in all of the animal reservoirs that exist.

Memory cells may take the form of

B CELLS,


T CYTOTOXIC CELLS


AND T HELPER CELLS

Schistosomiasis has increased in areas where

dams have been built

Regarding a mismatch of either the Rh antigen or the AB antigen, both


result in destruction of red blood cells.

The most common adjuvant is

alum

Which of the following causes a foodborne intoxication?

Staphylococcus aureus, E. coli O157:H7 AND Clostridium botulinum

The first identified case in an outbreak is called the

index case

C3b is involved in

opsonization

The publication of the CDC that reports new cases of reportable infectious diseases is titled

Morbidity and Mortality Weekly Report (MMWR).

scientist who made variolation safer and more effective was

Jenner

Specific chemical groups on an antigen molecule to which the immune response is directed are

antigenic determinants

Arthus reactions and serum sickness are examples of blank hypersensitivity.

type III

CD4 cells are often

T helper cells

The procedure developed by the Chinese to protect against smallpox was called
variolation

Smoking impairs the ciliated cells of the middle portion of the respiratory tract. Many analgesic drugs (painkillers) impair peristalsis (the churning motion of the digestive tract). The result of either of these activities leads to an increased risk of infection in their respective areas. Why?

The actions of the cells in these areas help to propel pathogens out of the area, serving as a part of the physical barrier system. When they are impaired/slowed, bacteria and other pathogens have an easier time adhering to the tissues in the area and causing an infection.

The zone size obtained in the Kirby-Bauer test is influenced by the drug's

size


stability


concentration

The antimicrobials produced by some molds and bacteria are generally called

antibiotics

T cell receptors are identical to antibodies

false

Cytotoxic T cells primarily are responsible for

cell-mediated immunity

Important sources of contamination in crowded locations are

droplets of saliva or mucus

The first host response to a nonspecific tissue injury is described as

inflammation

Serological tests are most often conducted in

microtiter plates

Home-canned foods should be boiled before consumption to prevent botulism. Considering that this treatment does NOT destroy endospores, why would it be helpful in preventing the disease?

Because the heat would denature the botulism exotoxin and inactivate it. The exotoxin is what leads to the disease symptoms, so this would make the food safer.

The number of cases of a specific disease per one hundred people exposed is called the

attack rate

Antiviral drugs may target

uncoating, nucleic acid synthesis AND viral assembly.

The low molecular weight protein produced by animal cells in response to viral infections is

interferon

Which is true about botox?


It may cause botulism AND it is useful in treating conditions related to muscle contractions.

Because of the natural evolution of microorganisms, it is necessary to use techniques that allow distinguishing them at the level of

strain

If the body recognizes parts of itself as being foreign, this is termed

autoimmune disease

One of the earliest researchers to explore the use of chemicals to kill microbial pathogens was

Ehrlich

Blood for transfusion is frequently tested for HIV by using the

ELISA method

Allografts


are normally rejected within 10-14 days, are grafts between non-identical members of the same species AND would include the fetus

Anti-A and anti-B antibodies


are considered natural antibodies AND are typically IgM.

The normal microbiota provides protection against potentially harmful organisms and stimulates the immune system. Why would the immune responses to members of the normal microbiota cross-react with pathogens?

Because pathogens are oftentimes more virulent strains of our own normal microbial flora, so they will 'look' roughly the same to our immune system (and be acted upon by our immune responses).

Which of the following is NOT a likely reason why diseases caused by opportunists are becoming more frequent in the US population?

Travel into and out of the United States has increased significantly. This has the potential to bring in many new pathogens that can cause new infections, even in otherwise healthy and immunocompetent individuals.

The first step in the establishment of infection is that the organism must

attach to host cells

The attraction of leukocytes to the area on inflammation is referred to as

chemotaxis

Diseases that primarily exist in animals, but may be transmitted to humans are called

zoonotic

The complex resulting from complement activity that leads to cell lysis is the

membrane attack complex

For which of the following childhood diseases is a subunit vaccine recommended?

pertussis

Vertical transmission involves

pregnant woman to fetus

An example of genetic variation used in pathogen survival may be

changing the pilus type

What would be a primary advantage of using an attenuated agent rather than just an antigen from that agent for a vaccine?

An attenuated agent strongly stimulates both the humoral (antibody) AND cell-mediated (T cell) portions of the adaptive immune response, giving the best comprehensive long-term protection available.

The leukocyte that contains histamine is the

basophil

In humans, the stem cells from which all blood cells arise are found in the

bone marrow

A recombinant vaccine is used to protect against

hepatitis B

To produce an allergic reaction in Type I hypersensitivity, the antigen


must crosslink two IgE molecules on mast cells.

Drugs that are bacteriostatic

inhibit the growth of bacteria

Which of the following is associated with contact dermatitis?


poison ivy, latex AND tuberculin skin test

Class II MHC molecules are found primarily on

macrophages AND dendritic cells.

Diseases that can be transmitted from one person to another are termed

communicable

Toxoids are used in vaccines against

diptheria

The immunity of some black Africans to malaria is probably due to their

genetic background

Generalized anaphylaxis is generally characterized by

shock

If the thymus fails to develop


functional T cells are absent AND Di George's syndrome exists.

The type of epidemiological study that determines the characteristics of the persons involved and the time and place of the outbreak is called a(n)

descriptive study

An epidemic that spreads worldwide is called a(n)

pandemic

T-independent antigens

include polysaccharides