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123 Cards in this Set
- Front
- Back
Rickettsia
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Bisella, very small, smaller than microplasma, gram (-), occur in any form, obligate parasites, almost all have insect vectors and insects are natural hosts.
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Rickettsia prowazekii – Old World or Epidemic Typhus.
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Symptoms – Headache,
high fever, shaking chills, rash, dehydration and level of consciousness decreases. Vectors are body lice (biological) |
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Rickettsia typhi – New World or Endemic typhus
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Similar to Old World but
milder. Vectors are body lice and rat fleas. Immunity to both after recovery from either. There is an individual vaccine for each. |
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Rickettsia rickettsii
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Rocky Mountain Spotted Fever.
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Rocky Mountain Spotted Fever. Eastern RMSF
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New England, is a mild disease. Vector is the dog tick
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Rocky Mountain Spotted Fever. Southwestern RMSF
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Texas. Vector is Lone Star tick
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Rocky Mountain Spotted Fever. Western RMSF
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Rockies, most severe form. Vector is wood tick.
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Rickettsia akari – Rickettsial pox.
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Even milder than RMSF. House mouse mite is
vector |
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Rickettsia conorii – Fievre boutoneusse
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Lesions form, crusts over with dark to
black crust. Found in African countries and in South American countries. Vector is sand flea |
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Rickettsia tsutsugamushii – Scrub typhus.
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Similar to mononucleosis. Fatigue,
mono. Mites are vectors |
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Rickettsia Quintana – Trench Fever.
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Humans are the natural host. Mechanical
vector. Body lice. Relapsing fever. Muscle and joint pain. Cane affect circulatory system. |
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Coxiella burnetti – Q Fever
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Similar to the flu. Self limiting. Exception to vector
rule, is a Zoonoses. Can be spread by respiratory route |
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Chlamydia
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– A bacteria, round to oval in shape. Once considered a virus. Has both RNA and DNA. Supposedly gram (-). Obligate parasite.
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Chlamydia trachomatis
1. Trachoma |
Extreme rare in U.S. Endemic in most of the world
(especially the tropics). Chronic conjunctivitis, always results in some vision loss, even total blindness. In tropics it’s the number one cause of blindness. Portal of Entry = Mucus Membrane of the Eye. Portal of Exit = Secretion from eye. Occurs from direct contact, phomites and by vectors such as flies |
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chlamydia trachomatis- . Inclusion conjunctivitis
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Sexually transmitted in adults. Also occurs
In infants on movement through birth canal. Infants will heal themselves. Found in U.S. |
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chlamydia trachomatis -Non-gonococcal urethritis
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Most common STD in U.S.
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chlamydia trachomatis -Pneumonia
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Milder form. Easily treatable.
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chlamydia trachomatis -Lymphogranuloma venerum
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Don’t see in U.S. Mostly in tropical
regions. Is a STD. Systematic symptoms. 20 times more common in men. Starts with ulceration of genitals. Quickly moves into lymphnodes. Continues, severe scarring of genitals |
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chlamydia trachomatis -Chlamydia psillici – Psitticosis
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Is a Zoonoses (birds). Respiratory
infection. Portal of Exit: respiratory secretions and feces of birds. Portal of Entry: Respiratory system. Not passed from human to human. |
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chlamydia trachomatis -Bartonella henselae and Quintana – Cat Scratch Fever
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Symptoms:
raised red rash and enlarge lymphnodes in area were scratched, fever. Complete recovery, no treatment. Portal of Entry: Skin. Portal of Exit: Dirty Cat. |
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Viruses
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All smaller than bacteria. Some as small as 20 nanometers. Have to use electron microscope to see. All are parasites. Are obligate antagonists. No cytoplasm. No organelles. Have to have host cell. Only have two shapes (Helix, spiral, and Icosahedrons has 20 triangular shaped faces to it). More viruses are icosahedrons. Consist of two components
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virus component: Capsid
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Outermost layer (cell wall)
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virus component: Genome
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Core of the virus, will find either RNA or DNA in genome not both
Viruses not considered to be living organisms. Some have envelope outside capsid, keeps it from being attached. Some have spikes. Examples of viruses with spikes are HIV. Viruses replicate by process of lysis |
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process of lysis: Attachment phase
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Attaches to cell
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process of lysis: Penetration phase
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Penetrates the cells
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process of lysis: Transcription phase
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DNA creates RNA
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process of lysis: DNA creates RNA
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Host cell creates viral protein (cells)
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process of lysis: Assembly phase
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Put proteins together to create cells
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process of lysis: Release phase
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Lysosomes destroys cell and release the viruses
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Retrovirus
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Is an RNA virus (no DNA). Have an enzyme called reverse transcriphase (allows cell to make DNA from RNA). HIV is a retro virus. All retroviruses have an extended latent period.
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Pathogensity
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ability to cause disease
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carcinogenic
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causes cancer
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teratogenic
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birth defects
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Retrovirus
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Is an RNA virus (no DNA). Have an enzyme called reverse transcriphase (allows cell to make DNA from RNA). HIV is a retro virus. All retroviruses have an extended latent period.
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ways to inactivate viruses are
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Ethyl Alcohol, Heavy Metal Compounds, Formaldehyde, Ultraviolet Light, Heat and Phenol.
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Attenuated vaccines
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when you take the virus and transfer it from one culture to another to weaken it, it can replicate but process of replication slowed down considerably.
Attenuated ones last longer. Usually have reactions from attenuated vaccines. |
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chain terminators
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There are medications, chain is RNA and DNA (nucleic acids). Example is Acyclovis (Herpes). Doesn’t kill virus just retards growth.
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Interpheron
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Interferes with viral RNA.
Has no effect on DNA. Used to treat Hep-C. Produced in very minute quantities and is species specific. |
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measles
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Dermatropic:
Virus Classification – Paromyrovirus Clinical Name – Rubeola Portal of Entry – Respiratory Portal of Exit – Discharge from respiratory/drainage from eye There is a vaccine, once get it lifetime immunity |
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Rubella
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Dermatropic:
Virus Classification – Paromyrovirus Clinical Name – Rubella (German measles) Portal of Entry – Respiratory Portal of Exit – Respiratory/Eye discharge Is teratogenic. Will affect nervous system in fetus causing miscarriage. Can’t take the vaccine when pregnant. Once get it have lifetime immunity |
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Small pox
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Dermatropic:
Virus Classification – Pox virus Clinical Name – Variola Portal of Entry – Respiratory Portal of Exit – Respiratory Largest virus. Highly contagious. Pandemics with 20% fatality. Only disease that has been eradicated. |
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Cow pox
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Dermatropic:
Virus Classification – Pox virus Clinical Name – Vaccina (Mild disease) Portal of Entry – Respiratory Portal of Exit – Respiratory Cow Pox gave immunity against small pox |
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Molluscum contagiosum
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Dermatropic:
Virus Classification – Pox Virus Clinical Name – Molluscum contagiosum Portal of Entry – Skin Portal of Exit – Skin Is skin tags that form all over body that stay after disease is gone |
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Chickenpox -> Shingles
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Dermatropic:
Virus Classification – Herpes Clinical Name – Varicilla Herpes zoster Portal of Entry – Respiratory Portal of Exit – Respiratory secretions When first contract, develop Chicken pox. Can reactivate as shingles. Pustules, rash then oozes. Shingles is painful, start along nerve roots. Deep seated, Vaccine is 60% effective |
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Herpes Simplex I
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Dermatropic:
Virus Classification – Herpes Clinical Name – Herpes Simplex I Portal of Entry – Respiratory Portal of Exit – Respiratory Causes cold sores/fever blisters around mouth and sometimes around eyes (keratitis) |
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Herpes Simplex II
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Dermatropic:
Virus Classification – Herpes Clinical Name – Herpes Simplex II Portal of Entry – Sexually transmitted Portal of Exit – Sexually transmitted/Birth canal Genital herpes. Lesions. Begin to show virus before lesions. Stays in body and reactivates from time to time. Causes are stress, fever and fatigue. Women during menstrual cycle and during pregnancy. Exposure to sunlight also causes activation. Having Herpes Simplex I raises immunity to Herpes Simplex II. |
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Influenza
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Pneumotropic:
Virus Classification – Myxovirus Clinical Name – Influenza Portal of Entry – Respiratory Portal of Exit – Respiratory Three divisions of Flu virus – A, B and C. 15 subtypes of A (most likely to be epidemic). Type B is milder. Type C is the mildest. It mutates very readily, can’t build resistance. Shot protects against 3 types but is a crap shoot. Can die from pneumonia. |
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Common Cold
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Pneumotropic:
Virus Classification – Rhinovirus/Koronavirus Clinical Name – Acute coryza Portal of Entry – Respiratory Portal of Exit – Respiratory Tons of viruses cause colds |
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Rabies-> Hydrophobia
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Neurotropic:
Virus Classification – Rhabdovirus Portal of Entry – Saliva Portal of Exit – Saliva Only one known case where person lived |
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phase 1 of rabies: Prodromal
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Feel sick, fever, etc. 15 – 30 days after contracted disease. If
treated you’ll be fine. |
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Phase 2 of rabies: Execution phase
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2 – 4 days after Prodromal phase. You will die. Can’t
swallow, foaming of the mouth. Dehydration |
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Phase 3 of rabies: Terminal phase
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convulsions, unconsciousness, death
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Diagnostic signs of rabies
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Negri bodies are on the brain, dark spots (resulting
from hemorrhages on brain) |
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Poliomyelitis
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Neurotropic:
Virus Classification – Picronavirus Clinical Name – Polio Smallest virus. Silent Polio – you contract virus but don’t develop symptoms. Paralytic polio – show symptoms. Past-polio syndrome – years after exposure. Haven’t seen in U.S. 30 – 40 years. |
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Encephalitis
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Neurotropic:
Virus Classification – Togavirus (arbovirus) Vectors are mosquitoes but can be spread by ticks and mites. Depending on location what type of encephalitis |
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Encephalitis, Eastern equine
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East/South U.S. 70% fatality rate
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Encephalitis, Western equine
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Western U.S. Milder disease. Low fatality rate.
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Encephalitis, Japanese B
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Japan, 100% fatality
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Encephalitis, St. Louis
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Throughout U.S. Low fatality rate
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Encephalitis, West Nile
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Throughout U.S. Birds are vectors, mosquitoes spread.
No treatment for this. Treat symptoms. Deficient after disease |
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Creutzfeldt - Jakob disease (CJD)
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Neurotropic:
caused by prion (fragment of protein) not virus. slow 20 – 25 years. Once it starts people dead in at least a year, most in 2 – 4 months. Don’t know how it is spread. Might be spread in blood. Sporadic. Can be spread by medical instruments use for brain surgery, fluid from the eye. Variant CJD from eating infected animals. History was a disease called Kuru from New Guinea, spread through cannibalism. Was in sheep also (scrapie). Spread from sheep to cows because we fed cows sheep meat (bovine spongiform encephalopathy, Mad Cow Disease). Eating meat that is contaminated called variant CJD. No known treatment |
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mumps
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Viscerotrophic:
Virus Classification – Paromyrovirus Clinical Name – Paratitis Portal of Entry – Respiratory Portal of Exit – Respiratory Inflammation of parotid glands. Can get it unilaterally or bilaterally. Permanent immunity once have it. There is a vaccine. Male might become sterile after puberty if contract mumps. Epididymo orchitis. Balls swell. Not common |
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Cytomegalovirus
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Viscerotrophic:
Virus Classification – Herpes Portal of Entry – Any route Portal of Exit –Any route Causes Cytomegalic inclusion disease (can affect any body system). Can cause either mild or fatal disease. Highly teratogenic. Frequently results in miscarriage |
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Epstein-Barr
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Viscerotrophic:
Virus Classification – Herpes Clinical Name – Mononucleous Portal of Entry –Respiratory Portal of Exit – Respiratory 99% of all people have been exposed. Affects lymphatic system. Is not contagious. Not a serious disease. Bruise easily, fever, etc. Long time to recover. Lymphoma is associated |
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Verruca
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Viscerotrophic:
Virus Classification – Papovavirus Clinical Name – Verruca Portal of Entry – Don’t Know Portal of Exit – Don’t know Warts. Stays in body |
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Condylama accumination
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Viscerotrophic:
Virus Classification – Pepovavirus Clinical Name – Condyloma Portal of Entry – Sexually transmitted Portal of Exit – Sexually transmitted Genital Warts. Grow together on genitals and anus. Looks like cauliflower. Highly contagious |
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Yellow Fever
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Viscerotrophic:
Virus Classification – Togavirus Clinical Name – Yellow Fever Vector is mosquito (biological). Is endemic outside the U.S. Sudden onset of high fever, destruction of liver (jaundice). Digestive system affected. Hemorrhaging occurs. High fatality rate 40% |
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Dengue Fever
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Viscerotrophic:
Virus Classification – Togavirus Vector is mosquito (biological). Is endemic outside of U.S. Sudden onset of high fever. Intense pain in joints, rash. Depressed function of lymphatic system |
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Ebola Virus
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Viscerotrophic:
Virus Classification – Hemorrhagic Fever Clinical Name – Filovirus Portal of Entry – Skin and Respiratory Portal of Exit – Blood, G I secretions, urine and semen Deadliest virus known. Close to 100% fatality rate. No treatment. Develop fever, headache, extreme weakness, muscle pain, respiratory symptoms and G I symptoms. Progresses to destroy kidneys and liver will fail. All organs will liquefy and hemorrhage from every orifice. Epidemics due occur. |
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Lasser Fever
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Viscerotrophic:
Virus Classification – Hemorrhagic Fever Clinical Name - togavirus Portal of Exit – Blood Not in U.S. In Africa. Host is rodents. Does spread from person to person. Epidemics that kill thousands |
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Hanta Virus
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Viscerotrophic:
Virus Classification – Hemorrhagic Fever Clinical Name – togavirus Portal of Entry – Reparatory Southwestern U. S. Pulmonary disease. Lungs fill with fluid and blood. can pass from person to person. Frequently fatal. Host is rodent (urine and feces) |
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rotavirus
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Viscerotrophic:
Caused by enterovirus, spread fecal oral route. several diff strand making immunity harder. 3 million cases every year in U. S. but less than 100 deaths per year. |
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Norwalk virus
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Viscerotrophic:
gastroenterittus enterovirus fecal/oral route accounts for 2/3 food borne illness. symptoms 2-5 days, over half of us population have anti-bodies against it |
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Hepatitis
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Inflammation of the liver. Various types of hepatitis
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Hepatitis Type A
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No envelope, spread through fecal oral spray. Usually enters blood stream, spreads to spleen and kidneys.
Amount of virus is greatest before any outward symptoms show, then decreases rapidly. Resistant to chlorine. Symptoms: Anorexia, malaise, nausea/vomiting, cramping/diarrhea, abdominal pain, fever/chills, jaundice, urine becomes dark, feces becomes light, photophobia, experiences pruritis. Last anywhere from 2 – 22 days. Low mortality rate. Incubation period 2 – 6 weeks. One dose vaccination. |
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Hepatitis type B
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DNA virus, has envelope, larger virus than Hep A.
Can be sexually transmitted but mostly through blood, semen, breast milk, saliva. Incubation period 4 – 26 weeks. Asymptomatic. Low mortality rate. Can have chronic carriers. If chronic can lead to liver disease. 3 dose vaccination. Have teder drawn. |
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Hepatitis type C
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Usually blood borne (transfusion). Incubation period 70 – 80 days.
Rapidly mutates. Can become chronic. Leads to syrosis of the liver and liver cancers. Leading cause for liver transplants. Kills more people in U.S. then AIDS. No vaccination |
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Hepatitis Type D
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– HDV. You had to have type B to get type D.
If you have B first than get D prognosis is good. If get B and D at same time = liver damage. Blood borne. |
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Hepatitis Type E
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Spread by fecal oral route. Don’t see a lot of this.
Mostly inn under developed countries. Is mild, except in infants and pregnant women |
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Hepatitis Type F
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Rare, in France and Italy. Don’t know how its spread
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Hepatitis type G
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Similar to Type C. Had to have B or C to get G.
Mild form. Is blood borne. Can be sexually transmitted. Can be passed to fetus |
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Non-viral Hepatitis
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Results from drugs or alcohol. Drugs like acetimetiphin
(Tylenol), tetracycline (anti-biotic) and phenol. |
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Autoimmune Hepatitis
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Own antibodies attack liver. Chronic.
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HIV
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from monkeys (simians), started as SIV.
Came from eating monkey. Transported to humans in about 1930’s (didn’t hear about it because Africa was undeveloped). Urbanization caused spread, same with prostitution. Earliest documented case was man who died in the 1950’s in Congo. In west, first case was Norwegian sailor in 1976 who had served in Africa in the 1930’s. In U. S. in 1981, from Canada to LA. Seen in male homosexuals. Retro virus. Classified as a lentivirus. Two strands of RNA that are identical. Reverse transcription. Has envelope and spikes. Receptor sites are found on helper T cells, on phagocyte cells and on nerve cells. Extended latent period. Formation of pro-virus during latent period (forms new cells but doesn’t leave host cell). Second stage – Forms latent virions Host cells replicating virus but remain in cell. Next stage is cell to cell fusion (moves cell to cell). Has high mutation rate because creating DNA from RNA. In asymptomatic people, its assumed virus mutates a million times a day. In AIDS patients it mutates one hundred million times a day. |
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HIV stages, Category A
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Person in asymptomatic or experiences lymphadenopathy
(swelling of the glands) |
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HIV stage, Category B
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Person starts to develop secondary infections. Lead to
Candide albieans which leads to thrush. Genital yeast infections and shingles will occur. On and off fever. A lot of G.I. problems |
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HIV stage, Category C
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AIDS Throat, bronchus and lungs. Other diseases will
occur such as CMU, TB, toxoplasmosis, pneumocytisis, carni pneumonia (most common cause of death in AIDS), Harposis sarcoma (most common cancer in AIDS) |
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Second Classification of HIV, Group I
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Acute illness, 50% of people who contract AIDS will develop
symptoms in 3 – 6 weeks. General symptoms, they will last a couple of weeks then go away. Are infectious during this stage. |
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Second Classification of HIV. Group II
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Asymptomatic infection.
Lasts months to years (no symptoms) 50% of people will develop AIDS in 7 – 10 years. Are infectious during this stage |
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Second Classification of HIV. Group III
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Generalize lympodenopathy
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Second Classification of HIV, Group IV
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Superimposed disease, AIDS
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Third Classification of HIV – T-cell count
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Normal T-cell count 800 – 1000 per cubic mm.
Below 200 is considered AIDS. There are at least 100 billion new viruses produced each day in a HIV patient. Most viruses form in T4-cells. A normal T4-cell should live several years, an infected T4-cell will live two days. |
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Survival with HIV
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About 5% of people who contract HIV are referred to as
long term non-progressors. Can go 20 – 25 years without progressing to AIDS. In a few cases virus is less virulent, but in most cases killer T-cells destroy helper T- cells before they replicate. Some people who are repeatedly exposed might have natural immunity. |
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Testing for HIV
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Checking for antibodies. Problem is long dormant period, most test can tell is 2 months after contracting disease.
There is a test to check for virus itself, in 48 hours, but it is expensive. Eliza is one type of test, faster results then Western blut test. |
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Transmission of HIV
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Direct contact with body fluids. Blood contain high
number, 1,000 and above. Semen contains low number, 10 to 100 viruses. Can live 6 hours outside a cell. Can cross placenta, contaminated needles, transfusions, transplants. Anal intercourse highest transmitter. Rare for oral to genital contract. Not spread by saliva, tears, sweat, casual contact, formites or vectors. World wide close to 3 million deaths. 50 million people infected. Leading cause of death in African countries. 16,000 new cases a day in Africa, almost all are heterosexual. In U.S. primary IV drug users and male homosexuals but heterosexual are gaining. Cannot develop vaccine, there are no subject to test on. |
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Medications for HIV
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To treat symptoms not cure the disease.
Popular drugs are AZT, ddI, ddC, they target reverse transcription, try to stop it. Protease inhibitors, works at cell level to stop host cell from producing protein. Interpheron has been used. Cocktail is at least 3 different medications |
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Infants and AIDS
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Problem testing infants for HIV. You will get a false positive due to Mother’s antibodies.
But infants progress at a much faster rate. |
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Three main things happen during AIDS, Immunodeficiency
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Opportunistic diseases and cancer
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Three main things happen during AIDS, Autoimmunity
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Body starts to destroy its own cells
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Three main things happen during AIDS, Neurologic dysfunction
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neuropathy, lose sensation and have no motor skills.
AIDS dementia |
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Changes Associated with AIDS, CNS
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Meningitis, encephalitis, AIDS dementia
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Changes Associated with AIDS, Mouth
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Herpes, thrush
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Changes Associated with AIDS, . Lung
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Pneumonia, tuberculosis
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Changes Associated with AIDS, Small intestine
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Malabsorbtion
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Changes Associated with AIDS, . Large intestine
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Colitis, proctitis (inflammation of the rectum due to chronic diarrhea
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Changes Associated with AIDS, Kidney
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Nephropathy (disease of the kidney resulting in kidney failure
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Changes Associated with AIDS, Skin
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Dermatitis, folliculitis, impetigo
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Changes Associated with AIDS, Lymph system
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Lymphadenopathy
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Changes Associated with AIDS, Lymphoma
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Brain, nodes, glands, spleen, liver. Frequent.
Non-AIDS starts in lymph system-> liver. In AIDS starts in nodes-> brain (that is what causes dementia) |
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Changes Associated with AIDS, Kaposi’s sarcoma
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Most common cancer in AIDS.
Starts as a skin cancer that starts in lower extremities. Will find nodules that will hemorrhage leaving purple/black marks. Will progress thru the body than move internally. No treatment |
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Common Secondary Infections Agents in AIDS
1. Candida albicans – |
Yeast, Causes thrush.
Goes thru respiratory system causing pneumonia |
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Common Secondary Infections Agents in AIDS
2. Cryptococcus neoformans – |
Yeast-Attacks central nervous system and causes meningitis.
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Common Secondary Infections Agents in AIDS
1. Pneumocystis carnii |
Protozoa– PCP. Leading infectious cause of death in AIDS.
Controversy over how to classify it. Recently been reclassified as a fungus (yeast). Ergosterol not present in fungal membrane. Cannot grow it in a culture. Used to be extremely rare but since AIDS it is more common. Don’t know what species it is. Close to 100% of children around the world have antibodies against it. Inhale it, then it goes dormant in your lungs unless you get AIDS. Can’t catch it from others. Aveli become inflamed. Lungs fill with mucus. Very aggressive combo of antibodies and sulfa drugs can save 50% of people who contract it. |
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Common Secondary Infections Agents in AIDS
2. Toxoplasma gondii |
Protozoa...Affects brain causing encephalitis, flagellates. 50% adults have antibodies. tetrogentic or miscarriage, blindess.
CATS ARE HOST! |
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Common Secondary Infections Agents in AIDS
3. Entaoemba histolytica – |
Protozoa...Affects G. I. systems causing protozoa dysentery
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Common Secondary Infections Agents in AIDS
4. Cryptosporidium species – |
Protozoa...Affect G. I. systems causing chronic diarrhea
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Common Secondary Infections Agents in AIDS
1. Mycobacterium tuberculosis – |
Bacteria, TB largest increase is in US
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Common Secondary Infections Agents in AIDS
2. Mycobacterium avium – |
Bacteria...Respiratory system. Mild form of TB
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Common Secondary Infections Agents in AIDS
3. Staphylococcus species |
Bacteria-Affects skin and the G.I. system
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Common Secondary Infections Agents in AIDS
4. Streptococcus species – |
Bacteria-Affects G. I. system
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Common Secondary Infections Agents in AIDS
1. Cytomegalovirus – |
Viruses-Affects the eye, can lead to lose of vision and blindness
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Common Secondary Infections Agents in AIDS
2. Herpes Simplex |
Viruses-Herpes
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Common Secondary Infections Agents in AIDS
3. Epstein-Barr virus – |
Viruses-Respiratory systems and lymphatic systems
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