Micro Exam 3- Virology 2

Front 1

dsDNA, icosahedral capsid, enveloped
most frequent isolate
HSV, VZV, EBV, HHV-6, HHV-7, HHV-8

Back 1

Herpesviridae

Front 2

Simplexvirus
transmitted by exposure to infected lesions
encephalitlis, nenoatlal herpes, and herpetic keratitis

Back 2

HSV

Front 3

HSV-2: in neonates
HSV-1: older children and adults
diagnose by brain biopsy/culture
can detect early in CSF w/ molecular amplification

Back 3

HSV- Encephalitis

Front 4

infants
symptomatic and fatal
vesicular skin lesions
treat with acyclovir or vidarabine

Back 4

HSV-Neonatal herpes infection

Front 5

2nd most common cause of corneal blindness
tonsilitis and pharyngitis

Back 5

HSV- Herpetic Keratitis

Front 6

Varicellovirus
chicken pox (varicella) and shingles/reactivation (zoster)
empryopathy-in pregnant women, <20 weeks
life threatening in immunocomp. (treat with ZIG)

Back 6

HSV- Varicella-Zoster (VZV)

Front 7

Lymphocryptovirus
Infectious mono

Back 7

HSV- EBV

Front 8

fever malaise, exudative pharyngitis, lymphadenopathy, lasts 10-20 days
secreted in saliva
infects B cells
can develop> neoplasm

Back 8

EBV

Front 9

Roseolovirus
causes exanthem subitum (6th disease)
-in children
-monolike symptoms with focal encephalitis

Back 9

HSV- Human Herpesvirus-6

Front 10

Roseolovirus
causes fever and roseola- red/brown skin lesions

Back 10

HSV- HHV-7

Front 11

Rhadinovirus
"Kaposi sarcoma-associated herpesvirus"

Back 11

HSV- HHV-8

Front 12

dsDNA
icosahedral capsid, naked
Adenovirus

Back 12

Adenoviridae

Front 13

Mastadenovirus
2nd most common cause of viral infant diarrhea
acute pharyngitis (mimics group-A strep)
conjunctivitis

Back 13

Adenovirus

Front 14

dsDNA
complex capsid with envelope (cytoplasmic)
Smallpox

Back 14

Poxviridae

Front 15

Variolavirus and Orthopoxvirus
extinct since 1975

Back 15

Smallpox

Front 16

dsDNA
icosahedral capsid, naked
BK,JC,SV40, and Human wart viruses

Back 16

Papoviridae

Front 17

Polymavirus
associated with hemorrhagic cystitis in bone marrow transplant recipients
JC- most important, causes destructive encephalitis

Back 17

Papoviridae- BK, JC, SV40 viruses

Front 18

Papillomavirus
warts, sexually transmitted venereal warts, and tumors (neoplasias) of respiratory and genitals

Back 18

Papoviridae- Human wart virus

Front 19

ssDNA
icosahedral capsid, naked
Parvovirus B19

Back 19

Parvoviridae

Front 20

Erythrovirus
erythema infectiosum (5th disease)
-slapped cheek syndrome

Back 20

Parvovirus B19

Front 21

segmented ssRNA
helical capsid, enveloped
Influenza A, B, C (Influenzavirus)

Back 21

Orthomyxoviridae

Front 22

ssRNA
non-segmented helical capsid, enveloped
Measles, Mumps, Parainfluenza, Respiratory syncytial virus

Back 22

Paramyxoviridae

Front 23

Morbillivirus
pneumonia and encephalitis
vaccine makes it rare

Back 23

Paramyxoviridae- Measles

Front 24

Paramyxovirus
infectiouns parotitis, aseptic meningitis
vaccine greatly reduces cases

Back 24

Paramyxoviridae- Mumps

Front 25

Paramyxovirus
croup and bronchiolitis in <2 year olds
mild respiratory illness in adults

Back 25

Paramyxoviridae- Parainfluenza

Front 26

Pneumovirus
recurrent respiratory infs. throughout life
nosocomial diseases
day cares (severe in young children)
croup, bronchitis, bronchiolitis, and interstitial pneumonia

Back 26

Paramyxoviridae- Respiratory Syncytial Virus

Front 27

ssRNA
icosahedra; capsid, naked
"small RNA viruses"
Rhinovirus and Enterovirus

Back 27

Picornaviridae

Front 28

Enterovirus
common cold

Back 28

Picornaviridae- Rhinovirus

Front 29

Enterovirus
poliovirus, coxsackievirus, echovirus, and enteroviruses 68-71

Back 29

Picornaviridae- Enteroviruses

Front 30

ssRNA
helical and enveloped (bullet shape)
Rabies

Back 30

Rhabdoviridae

Front 31

Lyssavirus
fatal viral zoonosis
most common bite transmitted virus (dogs)
fatal if PEP injection not administered
Neurotropic disease
-death with in days of late stage symptoms

Back 31

Rabies

Front 32

ssRNA
helical, enveloped
high fever, shock, multi. organ system involvement, and hemorrhage
exposure to body fluids
Marbugvirus
Ebolavirus (Sudan strain 50%, Zare strain 90%)

Back 32

Filoviridae

Front 33

segmented, ssRNA
helical, enveloped
transmitted by arthropods or rodents excreta
California encephalitis virus and Hantavirus

Back 33

Bunyaviridae

Front 34

Bunyavirus
mosquitoes

Back 34

Bunyaviridae- California Encephalitis Virus

Front 35

Bunyavirus
Sin Nombre
from aerosolized rodent feces
causes HPS
-hemorrhagic fever, kidney disease, acute respiratory failure, shock and renal failure

Back 35

Bunyaviridae- Hantavirus

Front 36

causes Human Gastroenteritis Virus (2)
acute vomiting/diarrhea, mild-selflimiting, non inflammatory

Back 36

Calciviridae and Reoviridae

Front 37

ssRNA
icosahedral, enveloped
Norovirus & Human Gastroenteritis Virus

Back 37

Calciviridae

Front 38

dsDNA
icosahedral, naked
Human Gastroenteritis Virus&
Rotavirus
-wheel-like
-#1 cause viral infant diarrhea

Back 38

Reoviridae

Front 39

ssRNA
helical, enveloped
colds and pneumonia
SARS-COV
-pandemic of respiratory disease, Hong Kong

Back 39

Coronaviridae

Front 40

ssRNA
icosahedral, enveloped
Rubella virus

Back 40

Togaviridae

Front 41

Rubrivirus
acute febrile illness with macropapular rash
-German measles (rash, face>body, lasts 3 days)
transient arthritis or encephalitis
transmitted by aerosols or transplacentally
-1st trimester, 75% neonated deaf/blind

Back 41

Rubella Virus

Front 42

ssRNA
capsid unknown, enveloped
Zoonotic- from rodent urine, feces, saliva
Old World Arenavirus and New World Arenavirus

Back 42

Arenaviridae

Front 43

Arenavirus
Lymphatic choriomeningitis virus
Lassa virus (W. Africa hemorrhagic fever)

Back 43

Avenaviridae- Old World Arenavirus

Front 44

Arenavirus
Tacaribe, Guanarito (Venezuelan hemorrhaic fever), Junin (Argentine h.f.) and Machupovirus (Bolivian h.f.)

Back 44

Avenaviridae- New World Arenavirus

Front 45

arthropod borne infection of small mammal, birds, and humans
caused by Togaviridae, Alphavirus and Flavavirus

Back 45

Arboviruses

Front 46

Group A- Arbovirus
ssRNA
mosquito/ticks
Eastern Equine Encephalitis Virus
Western Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus

Back 46

Togaviridae- Alphavirus

Front 47

Group B- Arbovirus
ssRNA
icosahedral, enveloped
mosquito/tick
common-mild, febrils
less common- severe, encephalitis, hemorrhaging, feverm and/or liver damage
causes West Nile, Dengue, and Yellow Fever

Back 47

Togaviridae- Flavavirus

Front 48

ssRNA
icosahedral (with 72 external spikes), enveloped
Human T-lymph Virus 1&2 and HIV

Back 48

Retroviridae

Front 49

Deltaretrovirus

Back 49

Retroviridae- HTLV- 1&2

Front 50

Lentivirus
sexual and parental transmission
initial infection
-transient febrile disease
-lymphadenopathy, pharyngitis, rash
-ARC
-also leukoplakia (white lesion on tongue)
6 weeks p.i.
-flu/mono like symptoms
AIDS
-T cells, CD4, <200/mm3

Back 50

Retroviridae- HIV

Front 51

Hepatitus Viruses (5)
symptoms- anorexia, malaise, dark urine, pale stool, vomiting, headache, jaundice

Back 51

HAV
HEV
HBV
HCV
HDV

Front 52

transmission- enteric
classification- Picornavirus
genome- ssRNA

Back 52

HAV

Front 53

transmission- enteric
classification- Hepevirus
genome- ssRNA

Back 53

HEV

Front 54

transmission- parental
classification- Hepadnavirus
genome-dsDNA
causes Hepatitis

Back 54

HBV

Front 55

transmission- parental
classification- Flavavirus
genome- ssRNA
causes Hepatitis

Back 55

HCV

Front 56

transmission- parental
classification- Deltavirus
genome- ssRNA
causes Hepatitis

Back 56

HDV