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16 Cards in this Set
- Front
- Back
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What are the properties of Bacillus
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gram positive
forms spores aerobic soild dwellers |
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what does the initiation of sporulation depends on the activity of what?
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two component regulatory system that is known as the Sporulation Phosphorelay
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what is the causative agent of anthrax
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Bacilus anthracis
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What are the three components of the Anthrax Toxin
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- PA: protective antigen "B"
- LF: Lethal factor "A" which cleaves MAPKK - EF: Edema factor "A" makes cAMP |
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How do you prevent and treat Anthrax
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Ab: Cipro and others
Vaccines exist but only used in endemicc areas |
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How does Bacillus cereus cause food poisoning?
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the emetic forms is cuase from eating contaminated rice with spores which make enterotoxin
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how are species Bacillus beneficial to humans?
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Bioinsecticides
Antibiotics high fructose corn syrup protease for laundry detergent |
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What are the general properties of Clostridium
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- Gram positive
- form spore - anaerobic - in soild and normal flora of GI |
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Which Clostridium are pathogenic?
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botulinum
tetani perfringes difficile |
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What are the three types of Botulism?
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-Food-borne: toxin in food
-Infant: spores ingested -Wound: spores get into wounds |
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Characterisics of the Botulism toxin
- C3 - C2 |
- it is a AB type neurotoxin
- very potent - C3 toxin - ADP ribosylates G pt - C2 toxin - ADP ribosylates actin |
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What causes Tetnus aka "lockjaw"
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cause by neurotoxin
it is a AB type toxins |
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What does BoNtox and TetNtox target
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BoNtox - cholinergic peripheral nerves
TetNtox - CNS inhibitory synapse |
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What are the characteristics C. perfringens?
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causes histotoxic infections and Gas Gangrene
leads to tissue damage and autolysis |
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What are the characteristics of C. difficile?
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- causes antibiotic associated gastrointestinal diseases
- pseudomembranous colitis an diarrheal disorders |
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What are the characteristics of C. difficile toxin?
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- AB type toxin
- UDP glucosyl transferases - produced during vegetative growth |
