Micro: Chlamydia

Front 1

chlamydia is a ___ parasite, infecting ___ and ___

Back 1

intracellular
columnar epithelial cells
macrophages

Front 2

chlamydia's cell wall resembles that of ___, but instead of peptidoglycan, it has ___.

Back 2

gram negative
P layer

Front 3

The P layer contains large & small ___. The outer membrane contains ___ and ___.

Back 3

CRP (cysteine rich protein)
MOMP (major outer membrane protein)
LPS

Front 4

Although Chlamydia is unable to synthesize ___, it does have ribosomes.

Back 4

amino acids

Front 5

The 2 parts of Chlamydia's life cycle are ___ and ___.

Back 5

elementary body
reticulate body

Front 6

T/F: The elementary body can proliferate.

Back 6

False

Front 7

T/F: The elementary body is infective.

Back 7

True

Front 8

The elementary body uses ___ for rigidity and ___ to trigger phagocytosis.

Back 8

disulfide bridges
adhesins

Front 9

The elementary body survives inside the phagocyte by __ (2)

Back 9

inhibiting lysosomal fusion
inhibiting MHC I expression

Front 10

After ___ hours, the elementary body changes to ___.

Back 10

8
reticulate body

Front 11

proliferation of the reticulate body in the ___ creates a ___

Back 11

phagosome
inclusion body

Front 12

___ h after infection, some reticulate bodies become ___

Back 12

48
elementary bodies

Front 13

T/F: Chlamydia stain gram negative.

Back 13

False: does not stain, although the bacterium is closely related to gram negative

Front 14

Chlamydia serotypes D-K cause ___ (4).

Back 14

neonatal (inclusion) conjunctivitis
infant pneumonia
non-gonococcal urethritis (NGU)
cervicitis

Front 15

NGU can present in women as ___ or ___, and at secondary sites cause ___ or ___.

Back 15

urethritis
cervicitis
salpingitis
pelvic inflammatory disease (PID)

Front 16

NGU can present in men as ___ and at secondary sites can cause ___.

Back 16

urethritis
epididymitis

Front 17

NGU is symptomatic in ___% of men and ___% of women.

Back 17

75
20

Front 18

Because they are parasitic, Chlamydia must be cultivated in 1 of ___ (3)

Back 18

lab animal
yolk sac
cell culture

Front 19

T/F: Reticulate bodies are larger than elementary bodies.

Back 19

true

Front 20

T/F: Disease is only from immune response.

Back 20

false: both cell necrosis and immune response

Front 21

Although symptomatically similar to ___, NGU can be distinguished from it by ___ (2)

Back 21

longer incubation time
more mucoid discharge

Front 22

T/F: NGU and gonorrhea can co-occur

Back 22

true

Front 23

Chlamydia serotypes L1-L3 cause ___.

Back 23

lymphogranuloma venereum (LGV)

Front 24

LGV is mainly seen in ___ (4)

Back 24

US gay men
asia
africa
south america

Front 25

LGV presents with ___ (2)

Back 25

painful papules on external genitalia
swelling of inguinal lymph nodes-> groove sign

Front 26

The groove sign in LGV is caused by

Back 26

obstructed lymph drainage due to fibrosis,

Front 27

Chlamydia serotypes A-C cause ___.

Back 27

trachoma

Front 28

trachoma is inflammation of ___ and ___.

Back 28

cornea
conjunctiva

Front 29

Inflammation in trachoma can cause ___ and as a result, ___.

Back 29

scarring
blindness

Front 30

trachoma is transmitted by ___ (3).

Back 30

droplets
hand contact
flies

Front 31

Neonatal conjunctivitis is transmitted by ___.

Back 31

birth canal

Front 32

T/F: Compared with trachoma, neonatal conjunctivitis causes blindness more frequenly.

Back 32

false: less frequently

Front 33

inclusion bodies may be stained by ___.

Back 33

Iodine

Front 34

T/F: cytology is effective for diagnosis

Back 34

false

Front 35

diagnosis is best by ___

Back 35

PCR

Front 36

treatment of Chlamydia is with

Back 36

tetracycline
erythromycin
sulfonamides

Front 37

T/F: both sexual partners should be treated

Back 37

true

Front 38

Reservoir of C. psittaci is ___

Back 38

birds

Front 39

C. psittaci is transmitted by ___

Back 39

inhalation of fomites with bird feces

Front 40

Infection by C. psittaci is called ___.

Back 40

psittacosis

Front 41

Psittacosis symptoms range from mild flu-like to ___

Back 41

toxic fulminant pneumonitis

Front 42

T/F: Recovery from psittacosis is often spontaneous within 2 weeks.

Back 42

False: Spontaneous recovery is within 6-8 weeks.

Front 43

Diagnosis of psittacosis is via ___.

Back 43

serology

Front 44

Treatment of psittacosis is ___.

Back 44

tetracyclines
erythromycin

Front 45

Chlamydophilia pneumoniae causes ___ & is also called ___

Back 45

atypical pneumonia
TWAR agent

Front 46

main contributing condition for C. pneumoniae transmission is ___.

Back 46

crowding

Front 47

T/F: C. pneumoniae infection typically affects a single lobe of the lungs

Back 47

true

Front 48

treatment of C. pneumoniae (2)

Back 48

erythromycin
tetracycline

Front 49

T/F: C. pneumoniae is an important cause of atherosclerosis.

Back 49

false: although it colonizes atherosclerotic plaques, it doesn't cause them