Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
31 Cards in this Set
- Front
- Back
|
why are sulfonamides not toxic to humans
|
the mechanism of action for these drugs inhibits the PABA in bacteria that make folic acid for the cell humans cant make there own religh on other sourses
|
|
|
what spacific enzyme is inhibited by sulfonamides
|
similar to pra-aminobenzoicacid (PABA) functions as a competitive inhibitor of this compound
|
|
|
what antimcobial is often combined ith sulfonamides.
|
trimethoprim
|
|
|
what pacific enzyme is inhibited by Trimethoprim
|
high afinity for bacterial dihydrofolate reductase
|
|
|
selective toxicity
|
the drug should kill pathgenic micoorganism but not damage host
|
|
|
two chemotheraputic agens use to treat TB
|
(INH)or isoniazid and ethambutol
|
|
|
what is the antibotic used with INH and ethambutol for TB
|
antibiotic rifampicin
|
|
|
what is the mechanisum or action for INH
|
interfers with cell wall synthesis in mycobaterium by inhibiting the production of mycolic acid
|
|
|
what is the mechanisum of action for Ethambutol
|
interferes with cell wall synthsis...inhibits icorporation of mycolic acid into mycrobacterial cell wall
|
|
|
what is the primary therputic use of nalidixic acid?
|
blockeds DNA synthesis in certin geam positive bacteria ( proteus, klebsiella, entrobacter and escherochoa)
|
|
|
mechanisum of action for Nalidixic acid
|
please see notes its a long one
|
|
|
2000 FDA aproved antibiotic " fist entierly new kind in 35 years
|
zyvox- linezolid
|
|
|
mechanisum of action for zyvox - linezolid
|
binds to the 23s ribosomal RNA of the 50s subunit, blocking the formation of the 70's ribosomal initiation complex
|
|
|
Clavulanic acid is sometimes added to semisynthetic penicillin becuase
|
it inactivates penicillinase
|
|
|
what do penicillin and cephalosporins have in common
|
Beta-lactams
|
|
|
penicillin and cephalosporins, have same mechanism what is it?
|
beta-lactams interfier spacificaly with new bacterial cell wall synthesis during cell division thus the transpeptidation step of peptidoglycan synthesis is inhibited.
|
|
|
what aminoglycoside is avalble in aresol for CF
|
tobramycin (tobi)
|
|
|
what aminoglycoside is in oitment form for bactirial conjunctivitis.
|
neomycin
|
|
|
neosporin has what 3 antibiotics
|
neomycin, polymyxin B and bacitracin
|
|
|
the wonder drugs quartet
|
penicillin steptomycin chloramphenicol and tetracycline
|
|
|
tetracyclines restricted in pregant women and babies due to
|
saining teeth yellow gray brown and stunt bone groth in childern
|
|
|
side effects of tetracyclines
|
reduce birth control effectivness, increase photosensitivity
|
|
|
long term use of tetracy.knes
|
kills body normal flora and predisoses to fungal disease such ans candida
|
|
|
legionnaries diseaase treatment
|
erythromycin
|
|
|
2 alternitves to silvernitrate for prevention of neissera and chlamydia in newborns eyes
|
erythromycin tetracyclines
|
|
|
what two drugs cause bithdefects
|
biaxin and zithromax (not recomened for prengate women)
|
|
|
vacomycin large size makes it good only for what type of gram bacteria
|
gram positive can not penetrat outer membrane of gram-neg bact.
|
|
|
two drugs are in the antibiotic synercid
|
quinupeiatin and dalfopristin
|
|
|
method of action for synercid
|
SEE NOTES!!!!!!!!!!!
|
|
|
method of action for rifamycin
|
inhibits the syntheis of mRNA by binding the procaryotic RNA polmyerase.... binds to the beta-subunit of RNAP and blocks the entry of the first nucleotide, thus blocking mRNA synthesis, it blocks the initiation of transcription
|
|
|
major sidefeect of rifamycin terapy
|
may cause the urin feces , saliva, sweat and tears to become ornge red color -- evidance that it may cause damage in some patents
|
