Micro Cartilage

Front 1

Define cartilage and the components that make up cartilage

Back 1

def= a dense supportive connective tissue
consists of cells (chondrocytes), fibers, and ground substance

Front 2

Fibers + ground substance make up the

Back 2

ECM = extracellular matrix

Front 3

Cartilage is vascular/ avascular

Back 3

avascular, no capillary bed

Front 4

Three types of cartilage

Back 4

hyaline, fibrocartilage, elastic cartilage

Front 5

name examples of hyaline cartilage

Back 5

developing bones, growth pate, articular surfaces, respiratory tract

Front 6

fibrocartilage can be found in

Back 6

intravertebral disks, cardiac skeleton, wher some tendons and muscle attach to bone

Front 7

elastic cartilage can be found in the

Back 7

epiglottis, pinna (part of your outer ear)

Front 8

chondrocytes

Back 8

mature cells w/in spaces in the cartilage ECM
-can be single or in isogenous groups
maintain cartilage

Front 9

Chondroblasts
def-
differentiated from-
produce-
appearance-
life cycle-

Back 9

cells that produce cartilage
mesenchymal
cartilage matrix
rounded wiht basophili cytoplasm
become chondrocytes once they are surrounded by ECM

Front 10

Lacuna

Back 10

space in the ECM occupied by the chondrocyte

Front 11

What is a valuable clue for identifying cartilage tissue

Back 11

lacunae

Front 12

Chondrocytes do or do not communicate with one another

Back 12

Do not communicate, are isolated

Front 13

Ground substance constituents include

Back 13

Proteoglycan aggregates containing GAGs
Hyaluronic acid in small amounts

Front 14

Ground substance has an affinity for _____. Proteoglycans absorb ____x their dry wt in interstitial fluid

Back 14

affinity for water
50x

Front 15

___charge of GAGs adn proteoglycans aids in resiliency of the tissue (repelling each other)

Back 15

Negative charge

Front 16

How do chondrocytes get their needed nutrients?

Back 16

Chondrocytes depend on diffusion of nutrients and waste products through the extracellular matrix. Cartilage is avascular and chondrocytes do not contact one another

Front 17

Describe the characteristic of the ECM and how this is intertwined wiht proteoglycan aggregates

Back 17

The extracellular matrix is sponge-like. The proteoglycan aggregates hold extracellular fluid which can be squeezed in and out of the cartilage

Front 18

Perichondrium is what type of connective tissue

Back 18

dense irregular CT surrounding cartilage in some places

Front 19

The ____layer of the perichondrium is chondrogenic. The ____layer is typical fibrous connective tissue

Back 19

inner layer is chondrogenic (cells of inner layer are chondroblasts resembling fibroblasts)
outer layer is typical fibrous CT

Front 20

________is NOT present on articular cartilage

Back 20

perichondrium

Front 21

Perichondrium is not identifiable around ______b/c _____is always found with dense connective tissue

Back 21

fibrocartilage

Front 22

Peri means

Back 22

around

Front 23

What are the two types of way cartilage can grow

Back 23

appositional or interstitial

Front 24

Describe appositional growth

Back 24

new cartilage is deposited on the surface of existing cartilage under the perichondrium.
Chondroblasts in the inner layer of the perichondrium become trapped by their own products to become chondrocytes.

Front 25

Describe interstitial growth

Back 25

the cartilage tissue can expand from within the tissue.
Chondrocytes within the cartilage can also divide and produce more cartilage.

Front 26

isogenous groups indicate____growth
Result from division of _____
Seen as clusters of _____

Back 26

Interstitial
chondrocytes in lacunae
2 or more lacunae in close proximity

Front 27

Hyaline cartilage
-ECM contains what type of fibers
-has ____staining ground substance

Back 27

fine collagen fibers (type II)-bot resolvable with LM
ECM has glassy (homogeneous) appearance
Basophilic ground substance

Front 28

How are chondrocytes found/ organized/ arranged in hyaline cartilage?

Back 28

Chondrocytes occur singly or in clusters (isogenous groups) and are randomly arranged in hyaline cartilage (with the exception of the zones of the growth plate of growing bone, and the zones of articular cartilage).

Front 29

Articular cartilage is a specialized type of _____cartilage to reduce friction

Back 29

hyaline cartilage

Front 30

Elastic cartilage is found places where flexibility is needed

Back 30

Epiglottis
External ear
Eustacian (auditory) tube

Front 31

what would differentiate hyaline cartilage of the trachea from elastic cartilage of the epiglottis, when stained with hematoxylin and eosin and viewed with a light microscope?

Back 31

Difference in the consistency of the extracellular matrix.
(presence of elastic fibers in ECM)

Front 32

Fibrocartilage has an abundance of ___fibers

Back 32

large collagen

Front 33

What is the most abundantly found cartilage in the body

Back 33

Hyaline cartilage

Front 34

Will see fibrocartilage develop in

Back 34

tendons and ligaments and some intervertebral disks

Front 35

How would you describe the cells of fibrocartilage

Back 35

rounded cells in lacunae, arranged in rows b/w colagen fibers

Front 36

How can you distinguish fibrocartilage form dense regular collagenous CT?

Back 36

look for round cells in lacunae to indentify fibrocartilage

Front 37

Can find fibrocartilage in __tissues
Look for ____pattern

Back 37

pubis symphysis
cardiac skeleton
intervertebral disk
cardiac skeleton
herringbone

Front 38

hyaline

Back 38

Hyaline

Front 39

The space containing a cartilage cell is called a ___

Back 39

lacunae

Front 40

fibrocartilage

Back 40

zoomed in

Front 41

lacunae

Back 41

lacunae

Front 42

isogenous groups

Back 42

isogenous groups- cells bound together

Front 43

identify this tissue section

Back 43

growth plate

Front 44

Find the perichondrium

Back 44

upper right hand corner of slide

Front 45

darker stained fibrocartilage

Back 45

darker stained fibrocartilage