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5 Cards in this Set
- Front
- Back
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1. Campylobacter jejuni (enteric disease)
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Short motile, comma-shaped or spiral gram-negative organisms
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Requires 4 special conditions for isolation.
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. These arc unique.
. Diminished oxygen (rnicroaerophilic), grow in increased C02 2. 42 degree incubation 3. Best isolated on selective media 4. May require extended incubation time |
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Can do... to detect ...
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direct microscopy (darkfield)
-darting, corkscrew motility |
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EPIDEMIOLOGY OF ENTERITIS
-causes -cases are -dever and tucson study of fx -third world -how common in US -how spread? -sensitive to? -inoculum -afe Peak incidence of enteritis -time peak in US -Invades -see... in stool |
A. Contaminated food and water, cases usually sporadic, may be outbreaks
B. Animal reservoirs include fowl, cattle, swine, sheep, dogs, cats, etc. C. Denver and Tucson studies show it in 5-8%of diarrheal stool cultures. Other U.S. studies have shown up to 10-12%. Third world frequency up to 30%. Most common bacterial cause of diarrhea in the U.S. D. Fecal-oral spread, sensitive to gastric acid. Requires 103to 106 organism inoculum. Also anal-genital-oral spread E. is 1-5 year olds. Summer peaks in North America More frequent than combined total of Salmonella and Shigella. F. intestinal mucosa. See WBCs and RBCs in stool samples |
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clinical disease
appearance of stool -duration and relapse -clearance -sheding of organism -Infection produces what antiboidies |
Rapid onset of fever, other constitutional symptoms, B. Abdominal pain in 90% of patients, especially in those with fever and anorexia, C. Some, < 50% have emesis, nausea, malaise, headache, myalgia
-diarrhea usually develops within 1 day of abdominal pain and fever (1-7 day incubation 2.Usually foul smelling, may be frankly bloody 1. Usually profuse, watery, may be mucoid, bile-stained -May last 2-9 days, but usually 3-5 days E. May have relapsing episodes. (Approximately 25% of untreated -G. Spontaneous organism clearance usually in 3-6 weeks in untreated cases -5-10% will continue to shed organisms in stool for year or longer (<3 weeks in 2/3 of patients) - 1gG and IgM antibodies |
