Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
What are the clinical features of B. pertussis infection?
|
Highly contagious (household spread 80%), lingering cough in adults, more significant morbidity in children. Mortality highest <6 mo. age
|
|
|
What are the three stages of B. pertussis in children?
|
1) Catarrhal - rhinorrhea, conjunctivitis, low-grade fever
2) Paroxysmal - cough/whoop fits 3) Convalescent - resolving, with occasional coughing fits |
|
|
What are the three stages of B. pertussis in adults?
|
Only one phase - prolonged, persistent coughing fits (ddx bronchitis, asthma exacerbations). Post-tussive vomiting common.
|
|
|
How is B. pertussis diagnosed?
|
H&P, PCR, leukocytosis, CXR (subtle, insensitive). *Reportable Disease*
|
|
|
Does B. pertussis cause pneumonia?
|
No, but secondary bacterial pneumonia is not uncommon.
|
|
|
What are the morphologic characteristics of B. pertussis?
|
Small gram negative coccobacillus. Fastidious in vitro.
|
|
|
What's the route of infection for B. pertussis?
|
Droplet transmission during coughing
|
|
|
What's the major virulence factor with B. pertussis?
|
Pertussis Toxin. AB toxin, ADP-ribosylates G-Proteins in respiratory epithelium, resulting in increased cAMP.
|
|
|
When are pertussis patients most contagious?
|
During the initial catarrhal stage.
|
|
|
What are the two syndromes associated with Legionella ssp?
|
Legionnaires' disease
Pontiac Fever |
|
|
What is the major clinical manifestation of Legionnaires' disease?
|
Pneumonia
|
|
|
What is the major clinical manifestation of Pontiac fever?
|
Acute, self-limiting febrile illness
|
|
|
Along with cough, what other symptoms present with Legionnaires' disease
|
Diarrhea, N/V common. HA, lethargy, stupor in 50%
|
|
|
What's the genus/species for most cases of Legionnaires' pneumonia?
|
L. pneumophilia (>90%)
|
|
|
What micro test is used to diagnose Legionnaires?
|
CYA (cough and stupor? cover your ass)
|
|
|
What are the morphologic characteristics of L. pneumophila?
|
Long, filamentous, intracelluar (phagosome) gram negative rods.
|
|
|
How does L. pneumophila present on CXR?
|
Unilateral lower lobe involvement.
|
|
|
What's the route for Legionella infection?
|
Aspiration of contaminated water, aerosol inhalation (HVAC systems).
Infected individuals are not contagious. |
