Micro And Immuno Pharm

Front 1

pen

Back 1

HSR, hemolytic anemia

Front 2

methicillin

Back 2

interstitial nephritis

Front 3

Ampicillin coverage

Back 3

AMPed up penicillin HELPS kill Enterococci

Haemohilus
e. coli
listeria
proteus
salmonella
enterococci

Front 4

Pseudomonas rx

Back 4

TCP Takes Care of Pseudomonas
Ticarcillin
carbienicillin
piperacillin

Front 5

cephs given in meningitis

Back 5

3rd generation (ceftriaxone, cefotaxime, ceftazedime) can penetrate BBB

Front 6

pseudomonas ceph

Back 6

ceftazedime (3rd)

Front 7

gonorrhea/klebsiella ceph

Back 7

ceftriaxone (3rd gen)

Front 8

SE cephs

Back 8

Penicillin HSR; nephrotoxicity of aminoglycosides is potentiated. disulfiram reaction with alcohol

Front 9

1st vs 2nd gen ceph Rx

Back 9

1st gen (PEcK - Proteus, E.coli, Klebsiella)

2nd gen (HEN PEcKS - haemophilus enterobacter aerogenes, neisseria, proteus, e. coli, Klebsiella, serratia)

Front 10

aztreonam doesn't have activity against _______

Back 10

gram positives and anaerobes (synergistic to aminoglycosides, so anaerobes dont work)

Front 11

imipenem SE

Back 11

cns toxicity (seizures); meropenem has a reduced risk of seizures.

Front 12

cilastatin use?

Back 12

used with imepenem; inhibits renal dihyropeptidase (imipenim metabolism); meropenem is dihydropeptidase resistant

Front 13

imipenem DOC for?

Back 13

enterobacter

Front 14

vancomycin SE and prevention of it?

Back 14

Nephrotoxic Ototoxic Thrombophlebitis, flushing RMS

Red Man Syndrome - pretreatment with antihistamines and slow infusion rate will prevent RMS.

Front 15

don't mix tetracyclin with ?

Back 15

cell wall inhibitor (pen, ceph, imipenim, aztreonam, vanc). prevents its action.

Front 16

aminoglycoside MoA

Back 16

misreading

Front 17

aminoglycoside for bowel surgery

Back 17

neomycin

Front 18

Aminoglycosides SE

Back 18

nephrotoxicity with aminoglycosides, ototoxicity (esp with loop diuretics), teratogenic

gentamycin has a curare like side effect (antinicotinic)

Front 19

tetracyclin moa

Back 19

prevents aminoacyl-trna attachment, blocks the a-site

Front 20

tetracyclins cant be taken with?

Back 20

antacids, iron containing preperations, or milk (absorption inhibited)

Front 21

doxycyclin specifically used in?

Back 21

patients with renal failure (fecal elim), others can give you fanconi's syndrome (RTA from PCT knockout)

Front 22

Tetracyclin (4 circles) RX for?

Back 22

4th time around, VACCUMING THe BedRoom:
vibrio, acne, chlamydia, ureaplasma, urealytica, mycoplasma, tularemia, h.pylori, Borrelia, rickettsia

(gets inside cells)

Front 23

macrolids moa

Back 23

blocks translocation

Front 24

community acquired strept pneumo drug?

Back 24

Azithro

Front 25

Legionella DOC?

Back 25

erythromycin

Front 26

chloramphenicol moa?

Back 26

inhibits peptidyltransferase activity

Front 27

clindamycin moa? whats its indication?

Back 27

inhibits peptide bond formation at 50S

anaerobes above the diaphragm

Front 28

Sulfonamides SE

Back 28

hemolysis in G6PDd, tubulointerstitial nephritis, kernicterus in infants, displaces other drugs (warfarin) from albumin

Front 29

sulfonamide moa

Back 29

inhibits dihydropteroate synthetase inhibiting folate synth

Front 30

pyrimethamine and trimethoprim moa

Back 30

dihydrofolate reductase inhibition, inhibiting folate synthesis

Front 31

TMP SE

Back 31

TMP: treats marrow poorly

megaloblastic anemia, leukopenia, granulocytopenia

give folinic acid so that you can make thymine, purines, methionin, glycine and f-met-trna

Front 32

antacids mess up which antibiotics

Back 32

tetracyclins and fluoroquinolones

Front 33

metronidazol uses

Back 33

anti protozoal: GET GAP on the Metro!

Giardia, Entamoeba, trichomonas, gardnerella, anaerobes (bacteroides, clostridium), Pylori

Front 34

metronidazol SEs

Back 34

disulfiram rxn, metallic taste

Front 35

INH (isoniazid) SE

prevention?

Back 35

INH - Injures Neurons and Hepatocytes

neurotoxic (convulsions and fasciculations) and hepatotoxic.
neurotoxicity prevented by pyridoxine (B6)

Front 36

ethambutol SE

Back 36

optic neuropathy, RED GREEN blindness

other TB drugs do hepatotoxicity

Front 37

SE for amphotericin

reduce toxicity?

Back 37

Amphoterrible - "Shake and bake", hypotension, nephrotoxicity, arrhythmias anemia, IV phlebitis.

hydration reduces nephrotoxicity, and liposomal amphotericin reduces toxicity.

Front 38

caspofungin is like what?

Back 38

like vancomycin, inhibits cell wall synthesis (in fungi) by inhibiting beta-glucan. causes flushing.

used for invasive aspergillosis

Front 39

azole antifungal SE

Back 39

gynecomastia, liver dysfunction (inhibited p450)

Front 40

griseofulvin SE

Back 40

teratogen, carcinogen, confusion, headache, increases p450 (greasy)

Front 41

amantadine moa

Back 41

blocks viral penetration, blocks M2 (uncoating), (influenza A, rubellA); releases dopamine (park rx)

mechanism of resistance is M2 mutation (common in influenza A)

Front 42

amantadine tox

alternative

Back 42

Amantadine blocks influenza A, rubellA, and gives problems to your cerebella

ATAXIA (also slurred speech and dizziness)

RIMANTIDINE doesnt cross the BBB so easily, less ataxia

Front 43

ribavirin is like what drug? what does it treat

Back 43

its like micophenolate mophetil...it inhibits guanine nucleoside synthesis which inhibits IMP dehydrogenase

treats chronic hep C and RSV

Front 44

ribavirin tox?

Back 44

hemolytic anemia, severe teratogenicity.

Front 45

acyclovir moa

Back 45

guanosine analog inhibits dna polymerase

Front 46

gancyclovir SE

Back 46

bone marrow toxicity and nephrotoxic

Front 47

foscarnet SE

Back 47

nephrotoxic

Front 48

protease inhibitor SE

Back 48

hyperglycemia, lipodstrophy, thrombocytopenia (indinavir)

Front 49

indinavir SE

Back 49

thrombocytopenia

Front 50

NRTI SE

Back 50

lactic acidosis, Bone Marrow, neuropathy

ZDV causes megaloblastic anemia

didanosine causes pancreatitis

Front 51

NNRTI toxicity

Back 51

rash, bone marrow, neuropathy

Front 52

enfuvirtide moa

Back 52

fusion inhibitor blocks gp41

2nd line drug when ARV not working.

Front 53

IFN toxicity

Back 53

neutropenia

Front 54

Antimicrobial Teratogenicity

Back 54

SAFE Moms Take Really Good Care
Sulfonamides - kernicterus
Aminoglycosides - ototox
fluoroquinolones - cartilage damage
erythro - acute cholestatic hepatitis in mom (clarithro - embryotoxic)
Metronidazol - mutagenesis
Tetracyclin - teeth, bone,
ribavirin - teratogenic
griseofulvin - teratogenic
chloramphenicol - gray baby (infants lack UDP-glucuronyl transferase)

Front 55

cyclosporine tox

prevention?

Back 55

nephrotoxic (dont give for renal transplants) which is preventable by mannitol diuresis)

Front 56

tacrolimus tox

Back 56

NEPHROTOXIC (dont give in renal transplant), neurotoxic, hypertension, leural effusion, hyperglycemia

Front 57

azathioprine se

Back 57

BM suppression, metabolite 6MP is metabolized by xanthin oxidase so allopurinol (which inhibits XO --> easier toxicity)

Front 58

muromonab toxicity

Back 58

cytokine release syndrome

Front 59

sirolimus what is it

Back 59

IL2 inhibitor that CAN be used in renal transplant

Front 60

sirolimus se

Back 60

hyperlipidemia, thrombocytopenia, leukopenia