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47 Cards in this Set

  • Front
  • Back
what is infection
Infection is the grow of microorganisms in the body
what is disease
disease is an abnormal state in which part or all of the body is not properly adjusted or is incapable of performing normal functions.
where is normal flora located
Normal flora is skin, eye, nose, throat, mouth, large intestine urinary and reproductive system
What is symbiosis
Symbiosis is the relation between the normal flora and the host
what are the types of symbiosis
parasite
commensal
mutalism
Koch’s postulates
The same pathogen must be present in every case of the disease, the pathogen must be isolated from the diseased host and grown in a pure culture,the pathogen from the pure culture must cause the disease when it is inoculated into a healthy, susceptible laboratory animal, the pathogen must be isolated from the inoculated animal and must be shown to be the original organism.
what is the exception to koch
some bacteria have unique requirements, some bacteria must grown in artificial media, a human host exhibits certain signs and symptoms associated with a certain pathogen and its disease, some pathogens can cause several disease conditions, some cause disease in only human hosts.
what is prevalence
Prevalence is the number of people in a population who develop the disease at a specific time, regardless of when it first appeared
what is occurance
when it occurs, like the season.
what is sporadic
if a disease occurs only occasionally
what is endemic
disease constantly in a population
what is epidemic
when many people acquire a certain disease in a relatively short period of time
what is pademic
epidemic that occurs worldwide
what are the period of disese development
incubation
prodromal
illness
decline
convelance
what are 3 disease reservoirs
human
animal
nonliving (soil and water)
what are 3 types of contact transmission of a disease
indirect
direct
droplet
what is indirect transmission
agent of disease is transmitted from the reservoir to host by means of non-living objects
what is direct transmission
person to person contact, physical contact
what is droplet transmission
droplets are spread, only travel short distance
what are three types of vehicle transmission of a disease
waterborne
airborne
foodborne
waterborne transmission
pathogens spread by untreated water or poorly treated sewage
airborne transmission
spread of agents by droplet that travel more than 1 meter from the host. Staphylococci and Streptococci
food borne transmission
transmitted in foods that aren’t cooked well enough, poorly refrigerated, or prepared in unsanitary conditions. Tapeworm infection
three conditions that lead to noscomial infections
microrgan in hospital
compromised host
chain of transmission
what are 3 portals of entry
mucous membrand
skin
parenteral
What is meant by ID50 and LD50?
ID50 is the infectious dose of 50% of the sample population; LD50 is the lethal dose for 50% of the population
What is ment by adherence? Why is this important?
It is attachment for pathogens; it is a necessary step in pathogenicity.
Ways that pathogenic organisms penetrate evade or defeat host cell
capsule
cell wall componets
enzymes
antigenic variation
how can organ pentrate by capsule
increases virulence of the species, impairs phagocytosis of host
how can organ pentrate by cell wall componets
mediates attachment to epithial cells of hosts, can use fimbrae
how can organ pentrate by enzymes
coagulase- coagulate fibrin in blood, kinase- break down fibrin and digest clots, Hyaluronidase- hydrolyses acid
classifcation of infectios disese
signs and symp
ability to spread
occurance and range
duration
local infection
pathogens are limited to a small area of the body
focal infection
systemic infection that began as a local infection
primary infection
acute infection that causes intial illness
secondary infection
opportunistic infection after a primary infection
subclinical disease
no noticable signs or symptoms
disese duration
acute
chronic
subacute
latent
how does ruputure of cells happen
intracellular microrg
bacterial toxin
endotoxin
exotoxin
endotoxin
secreted
protein
act on host cell
bind to host and change behavior
exotoxin
not secreted
cell wall of gram (-)
not protein
lipidpolysac- outer cell membrane
a-b toxin
two subunits
lots of examples
"b" binds to toxin membrane
"a" is toxic
membrane disrupting
disrupt phospolipid
form non-specfic protein pore
super antigens
non specfic antigen
cytokines are released, causes body to overact
tumor necrosis factor
released from phagocyotosis, cause massive dialation of capillary
once in a cell how can damage occur
host anabolism stop
cytocidal virus may cause release of lyosomial contents
causes host to self-digest
inclusion
transformation
change surface host