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47 Cards in this Set
- Front
- Back
what is infection
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Infection is the grow of microorganisms in the body
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what is disease
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disease is an abnormal state in which part or all of the body is not properly adjusted or is incapable of performing normal functions.
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where is normal flora located
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Normal flora is skin, eye, nose, throat, mouth, large intestine urinary and reproductive system
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What is symbiosis
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Symbiosis is the relation between the normal flora and the host
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what are the types of symbiosis
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parasite
commensal mutalism |
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Koch’s postulates
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The same pathogen must be present in every case of the disease, the pathogen must be isolated from the diseased host and grown in a pure culture,the pathogen from the pure culture must cause the disease when it is inoculated into a healthy, susceptible laboratory animal, the pathogen must be isolated from the inoculated animal and must be shown to be the original organism.
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what is the exception to koch
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some bacteria have unique requirements, some bacteria must grown in artificial media, a human host exhibits certain signs and symptoms associated with a certain pathogen and its disease, some pathogens can cause several disease conditions, some cause disease in only human hosts.
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what is prevalence
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Prevalence is the number of people in a population who develop the disease at a specific time, regardless of when it first appeared
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what is occurance
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when it occurs, like the season.
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what is sporadic
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if a disease occurs only occasionally
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what is endemic
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disease constantly in a population
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what is epidemic
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when many people acquire a certain disease in a relatively short period of time
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what is pademic
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epidemic that occurs worldwide
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what are the period of disese development
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incubation
prodromal illness decline convelance |
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what are 3 disease reservoirs
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human
animal nonliving (soil and water) |
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what are 3 types of contact transmission of a disease
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indirect
direct droplet |
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what is indirect transmission
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agent of disease is transmitted from the reservoir to host by means of non-living objects
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what is direct transmission
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person to person contact, physical contact
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what is droplet transmission
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droplets are spread, only travel short distance
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what are three types of vehicle transmission of a disease
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waterborne
airborne foodborne |
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waterborne transmission
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pathogens spread by untreated water or poorly treated sewage
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airborne transmission
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spread of agents by droplet that travel more than 1 meter from the host. Staphylococci and Streptococci
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food borne transmission
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transmitted in foods that aren’t cooked well enough, poorly refrigerated, or prepared in unsanitary conditions. Tapeworm infection
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three conditions that lead to noscomial infections
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microrgan in hospital
compromised host chain of transmission |
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what are 3 portals of entry
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mucous membrand
skin parenteral |
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What is meant by ID50 and LD50?
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ID50 is the infectious dose of 50% of the sample population; LD50 is the lethal dose for 50% of the population
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What is ment by adherence? Why is this important?
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It is attachment for pathogens; it is a necessary step in pathogenicity.
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Ways that pathogenic organisms penetrate evade or defeat host cell
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capsule
cell wall componets enzymes antigenic variation |
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how can organ pentrate by capsule
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increases virulence of the species, impairs phagocytosis of host
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how can organ pentrate by cell wall componets
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mediates attachment to epithial cells of hosts, can use fimbrae
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how can organ pentrate by enzymes
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coagulase- coagulate fibrin in blood, kinase- break down fibrin and digest clots, Hyaluronidase- hydrolyses acid
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classifcation of infectios disese
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signs and symp
ability to spread occurance and range duration |
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local infection
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pathogens are limited to a small area of the body
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focal infection
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systemic infection that began as a local infection
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primary infection
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acute infection that causes intial illness
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secondary infection
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opportunistic infection after a primary infection
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subclinical disease
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no noticable signs or symptoms
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disese duration
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acute
chronic subacute latent |
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how does ruputure of cells happen
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intracellular microrg
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bacterial toxin
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endotoxin
exotoxin |
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endotoxin
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secreted
protein act on host cell bind to host and change behavior |
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exotoxin
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not secreted
cell wall of gram (-) not protein lipidpolysac- outer cell membrane |
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a-b toxin
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two subunits
lots of examples "b" binds to toxin membrane "a" is toxic |
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membrane disrupting
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disrupt phospolipid
form non-specfic protein pore |
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super antigens
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non specfic antigen
cytokines are released, causes body to overact |
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tumor necrosis factor
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released from phagocyotosis, cause massive dialation of capillary
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once in a cell how can damage occur
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host anabolism stop
cytocidal virus may cause release of lyosomial contents causes host to self-digest inclusion transformation change surface host |