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16 Cards in this Set
- Front
- Back
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Strep pneumonia
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polysacharide capsule-85 antigens and retards phogocytosis
produces IgA protease |
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Strep Pyogenes
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-LTA-sticks to fibronectin
-Streptokinase-dissolves clots -M-protein-blocks complement ddeposition, inhibits phagocytosis -hyaluronidase -C5a peptidase-cleaves C5a and destroys its signal -streptolysin S and O-hemolysins O is antigenic S is not --Streptococcoal pyogenic eexotoxins- erythrogenic toxin types A,B,C scarlet fever and staph shock syndrome -streptococcal DNAse-depolymerizes DNA in necrotic tissue -exotoxin B-destroys tissue protease, necrotizing fasciitis |
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Strep agalacticea
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No specific toxins
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Enterococci
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no virulence factors, low virulence
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Viridans, strep mutans
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dextrans enhance adherence to heart valves
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Staph Aureus
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-enterotoxin-stimulates release of IL-1 and IL-2 mod. heat resistant
-Toxic Schock-binds to MHC molecules, T cells result in release of IL-1 and IL-2(super antigen) -exfoliatin- scalded skin -alpha toxin- hemolysis and necrosis of skin -catalse-counteracts neutrophils -coagulase-converts fibrinogen to fibrin, neutrophils can't penetrate clots to reach organism -hyaluronidase -b-lactamase-hydrolyzes penicillin Teichoic Acid- Protein A- binds nonspecifically to Fc portion of immunoglobulin |
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Staph Saprophyticus
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None
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Staph epidermidis
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-exopolysacharide that may aid in adherence to plastci surfaces
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Bacillus antracis
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-polyglutamic acid capsule
-2 Proteins in AB configuration --Edema Factor-adenylate cyclase --protective antigen-binds to cell surface receptor and is then cleaved by cellular protease. Remaining protective antigen on cell surface binds edema factor or lethal factor allowing entry into cell --lethal factor- cleaves phosphokinase that activates cell growth-results in inhibition |
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Bacillus cereus
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-Enterotoxins ADP-ribosylates a G protein that stimulates adeylate cyclase and leads to increases cAMP
-2nd is a super toxin |
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Clostridium tetani
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tetanospasmin-binds periphereal nerves and is transported inta-axonally to the CNS where it binds to ganglioside receptors and blocks releas of inhibitory neurotransmitters
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Clostridium perfingens
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release of inflammatory mediators in the gut
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Clostridium difficle
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-exotoxin A and B-damage mucosa and produces characteristics yellow pseudomembrane visible on the colon
-glucosylate a G protein involved involved in actin filament polymerization, depolymerization of actin results in loss of cyoskeletal integrity, apoptosis, and cell death |
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Clostridium botulinum
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-polypeptide exotoxin inhibits the release of acetylcholine at myoneural junction causing flacid paralysis
-8 immunologically distinct neurotoxins with human disease usually caused by types A,B, and E. Extremely potent toxins but are heat labile. ADP-ribosylating C2 and C3 toxins cause cytotoxicity |
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Listeria monocytogenes
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-effect immunosuppresed patients
-Actin rockets allow movements btwn cells |
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Corynbacterium diphtheriae
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-inhibits protein synthesis in eukaryotic cells, two functional domains linked by disulfide bridges
--subunit B- binds to glycoprotein receptors on cell membranes --subunit A- enzymatic activity, cleaves nicotinamide from NAD and transfers remaining ADP-ribose to EF2, inactivating it -DNA for this toxin is from a bacteriophage |
