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20 Cards in this Set
- Front
- Back
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MRSA → Staph A. resistant to methicillin (and most related antibiotics)
- Carry a new gene (____) encoding an altered PBP |
mecA
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_____ found that filtration of tobacco plant extract
did not remove the agent causing tobacco mosaic disease( ⇒ “filterable virus”) |
Iwanowski
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Viruses have ____(will only infect one type of cell or host)
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host specificity
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- single stranded RNA (“Plus” orientation = ____)
- single stranded RNA (“Minus” orientation = ____) |
mRNA
anti-mRNA |
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A virus will contain only ___ type of nucleic acid
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one
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Protein coat that surrounds nucleic acid core consists of individual protein subunits (____) which
combine to make a complete shell (______)→ Three basic shapes:Helical,Icosahedral, Complex |
Capsomers
Capsid |
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One exception to the size rule: _____ (“mimicking microbe”)- recently discovered as a virus of amoebas - larger in size than the smallest bacteria
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Mimivirus
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Outside of host cell, viruses exist as “____”
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Virions
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Lytic Infection= “____” phage
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Virulent
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Use ____ to Determine Number of Lytic Phage in a Population
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Plaque Count Assay (total # of plaques = total # of virions in original) sample
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Lysogenic Infection= “____” phage
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Temperate phage (eg. phage Lambda)
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In lysogenic inf. Virus genome recombines into bacterial chromosome
( = “____”) |
Prophage
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___ is when phage carry genes that alter phenotype of bacterial host
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Lysogenic Conversion
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Spike + receptor interaction determines virus____ and tissue specificity (only cells with a complementary
receptor can be infected) |
host range
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For Penetration of enveloped virus, method can be ___ or ___
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fusion or endocytosed
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______ is the separation of viral genome from its protein coat
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“Uncoating”
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DNA virus genome contains:
- “____” genes → transcribed immediately after entry into cell - “____” genes → transcribed only after new viral RNA pol. made |
Early
Late |
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If viral genome is RNA: Different strategies depending on whether “_____” or “____” RNA
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“Plus” or “Minus” RNA
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Budding of enveloped virus may or may not kill host cell - If host cell survives → possible continual virus production & release over time (= “_____”)
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virus shedding
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Host Cell Transformation(oncogenes):
• Formation of cancerous host cells by “tumor” viruses HTLV-1 (RNA) ⇒ _____ Papilloma virus (DNA) ⇒ ____ Epstein-Barr Virus (DNA) ⇒__ |
T-cell leukemia
cervical cancers Burkitt’s lymphoma |
